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    HHF2 histone H4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855701, updated on 1-Aug-2024

    Summary

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    Gene symbol
    HHF2
    Gene description
    histone H4
    Primary source
    FungiDB:YNL030W
    Locus tag
    YNL030W
    See related
    SGD:S000004975; AllianceGenome:SGD:S000004975; VEuPathDB:YNL030W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable DNA binding activity. Involved in histone H3-K79 methylation; sexual sporulation resulting in formation of a cellular spore; and transfer RNA gene-mediated silencing. Part of replication fork protection complex. Orthologous to several human genes including H4C15 (H4 clustered histone 15). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See HHF2 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (576727..577038)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene putative tyrosine protein phosphatase SIW14 Neighboring gene histone H3 Neighboring gene putative mannosyltransferase Neighboring gene DNA-binding transcription factor CRZ1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genomic integration method for the simultaneous visualization of endogenous mRNAs and their translation products in living yeast. Haim-Vilmovsky L, et al. RNA, 2011 Dec. PMID 22025736, Free PMC Article
    2. Identification of novel histone post-translational modifications by peptide mass fingerprinting. Zhang L, et al. Chromosoma, 2003 Aug. PMID 12937907
    3. Crosstalk between chromatin structure, cohesin activity and transcription. Maya-Miles D, et al. Epigenetics Chromatin, 2019 Jul 22. PMID 31331360, Free PMC Article
    4. Regulated acetylation and deacetylation of H4 K16 is essential for efficient NER in Saccharomyces cerevisiae. Ray A, et al. DNA Repair (Amst), 2018 Dec. PMID 30274769
    5. Positive Charge of Arginine Residues on Histone H4 Tail Is Required for Maintenance of Mating Type in Saccharomyces cerevisiae. Yeom S, et al. J Microbiol Biotechnol, 2018 Sep 28. PMID 30176714

    See all (386) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that DNA replication largely results in nucleosomes bearing exclusively old or new H3-H4.
      Title: Splitting of H3-H4 tetramers at transcriptionally active genes undergoing dynamic histone exchange.
    2. analysis of the histone H3 and histone H4 core modifiable residues in Saccharomyces cerevisiae
      Title: Insights into the role of histone H3 and histone H4 core modifiable residues in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nucleosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    histone H4
    NP_014368.1
    • Histone H4; core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF1); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      576727..577038
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182869.1 → NP_014368.1  TPA: histone H4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014368.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ10, P02309
      UniProtKB/TrEMBL
      A6ZKV6, B3LND1, C7GM41, C8Z404, C8ZFK7, G2W917, N1PAQ9
      Conserved Domains (1) summary
      PTZ00015
      Location:18 → 101
      PTZ00015; histone H4; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P02309.2

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