HHO1 histone H1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: HHO1
Gene description: histone H1
Primary source: FungiDB:YPL127C
Locus tag: YPL127C
See related: SGD:S000006048; AllianceGenome:SGD:S000006048; VEuPathDB:YPL127C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables DNA binding activity. Involved in chromosome condensation; negative regulation of DNA recombination; and regulation of transcription, DNA-templated. Acts upstream of or within regulation of double-strand break repair. Located in chromatin and nucleus. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to several human genes including H1-0 (H1.0 linker histone). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See HHO1 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (308828..309604, complement)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Single-molecule study reveals Hmo1, not Hho1, promotes chromatin assembly in budding yeast.
Title: Single-molecule study reveals Hmo1, not Hho1, promotes chromatin assembly in budding yeast.
Actin-Related Protein 4 and Linker Histone Sustain Yeast Replicative Ageing.
Title: Actin-Related Protein 4 and Linker Histone Sustain Yeast Replicative Ageing.
The linker histone Hho1 modulates the activity of ATP-dependent chromatin remodeling complexes.
Title: The linker histone Hho1 modulates the activity of ATP-dependent chromatin remodeling complexes.
Systematic analysis of linker histone PTM hotspots reveals phosphorylation sites that modulate homologous recombination and DSB repair.
Title: Systematic analysis of linker histone PTM hotspots reveals phosphorylation sites that modulate homologous recombination and DSB repair.
Saccharomyces cerevisiae linker histone - Hho1p, physically interacts with the actin-related protein 4 (Arp4) and that the abrogation of this interaction through the deletion of the gene for the linker histone in arp4 mutant cells leads to global changes in chromatin compaction.
Title: Linker histones and chromatin remodelling complexes maintain genome stability and control cellular ageing.
data suggest that complete absence of Hho1 from chromatin does not affect reciprocal recombination between homologous chromosomes during meiosis
Title: Evidence that histone H1 is dispensable for proper meiotic recombination in budding yeast.
deletion of HHO1 gene in S. cerevisiae leads to alterations in the higher-order levels of chromatin organization.
Title: Hho1p, the linker histone of Saccharomyces cerevisiae, is important for the proper chromatin organization in vivo.
Hho1 may play a dual role during sporulation: Hho1 and Ume6 depletion facilitates the onset of meiosis via activation of Ume6-repressed early meiotic genes, whereas Hho1 enrichment in mature spores contributes to spore genome compaction.
Title: The linker histone plays a dual role during gametogenesis in Saccharomyces cerevisiae.
mode of Hho1p action is similar to that of canonical linker histones
Title: Saccharomyces cerevisiae linker histone Hho1p functionally interacts with core histone H4 and negatively regulates the establishment of transcriptionally silent chromatin.
Hho1p has a limited role in transcriptional regulation; this dynamically exchanging linker histone may be evicted from chromatin by transcriptional activity.
Title: The Saccharomyces cerevisiae linker histone Hho1p is essential for chromatin compaction in stationary phase and is displaced by transcription.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleosomal DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of chromatin	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromosome condensation	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromosome condensation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleosome assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of double-strand break repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sporulation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
part_of nucleosome	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: histone H1

NP_015198.1

Histone H1, linker histone with roles in meiosis and sporulation; decreasing levels early in sporulation may promote meiosis, and increasing levels during sporulation facilitate compaction of spore chromatin; binds to promoters and within genes in mature spores; may be recruited by Ume6p to promoter regions, contributing to transcriptional repression outside of meiosis; suppresses DNA repair involving homologous recombination