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    RPL5 ribosomal 60S subunit protein L5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855972, updated on 7-Jul-2024

    Summary

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    Gene symbol
    RPL5
    Gene description
    ribosomal 60S subunit protein L5
    Primary source
    FungiDB:YPL131W
    Locus tag
    YPL131W
    See related
    SGD:S000006052; AllianceGenome:SGD:S000006052; VEuPathDB:YPL131W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    LPI14; RPL1
    Summary
    Enables 5S rRNA binding activity. Involved in ribosomal large subunit assembly. Part of cytosolic large ribosomal subunit. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 6; T-cell acute lymphoblastic leukemia; and glioblastoma. Orthologous to human RPL5 (ribosomal protein L5). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RPL5 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (303121..304014)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene gluconeogenesis transcription factor RDS2 Neighboring gene Cox11p Neighboring gene Spo19p Neighboring gene TATA-binding protein-associated factor TAF14

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional features of the C-terminal region of yeast ribosomal protein L5. Moradi H, et al. Mol Genet Genomics, 2008 Oct. PMID 18751732
    2. Differentiating between near- and non-cognate codons in Saccharomyces cerevisiae. Plant EP, et al. PLoS One, 2007 Jun 13. PMID 17565370, Free PMC Article
    3. A second-site mutation at glutamate-257 that restores the function of the mutant yeast ribosomal protein L5 containing lysine-270,271-->arginine. Yeh LC, et al. Biochim Biophys Acta, 1999 Dec 23. PMID 10673025
    4. Involvement of lysine 270 and lysine 271 of yeast 5S rRNA binding protein in RNA binding and ribosome assembly. Yeh LC, et al. Biochim Biophys Acta, 1996 Aug 14. PMID 8764831
    5. Multiple regions of yeast ribosomal protein L1 are important for its interaction with 5 S rRNA and assembly into ribosomes. Deshmukh M, et al. J Biol Chem, 1995 Dec 15. PMID 8530422

    See all (161) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Depletion of Cgr1 results in inhibition of 5S ribonucleoprotein(RNP) rotation, but suppressor mutations mapping in factors Rpf2, Rrs1, and Rpl5, stabilizing the pre-rotational stage of the 5S RNP, partly overcome this defect.
      Title: Suppressor mutations in Rpf2-Rrs1 or Rpl5 bypass the Cgr1 function for pre-ribosomal 5S RNP-rotation.
    2. study identifies a transport adaptor, symportin 1 (Syo1)Ydl063c, that facilitates synchronized coimport of the 5S-rRNA binding proteins Rpl5 and Rpl11; symportin-mediated coimport of Rpl5-Rpl11 could ensure coordinated and stoichiometric incorporation of these proteins into pre-60S ribosomes
      Title: Synchronizing nuclear import of ribosomal proteins with ribosome assembly.
    3. identified a ribonucleoprotein neighborhood in preribosomes that contains two ribosome assembly factors, Rpf2 and Rrs1, two ribosomal proteins, rpL5 and rpL11, and 5S rRNA
      Title: Assembly factors Rpf2 and Rrs1 recruit 5S rRNA and ribosomal proteins rpL5 and rpL11 into nascent ribosomes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 5S rRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5S rRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 5S rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IC
    Inferred by Curator
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in ribosomal large subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal large subunit assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal 60S subunit protein L5
    NP_015194.1
    • Ribosomal 60S subunit protein L5; nascent Rpl5p is bound by specific chaperone Syo1p during translation; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      303121..304014
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183945.1 → NP_015194.1  TPA: ribosomal 60S subunit protein L5 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015194.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3N6, P26321
      UniProtKB/TrEMBL
      A0A6A5Q0W8, A6ZWC1, B3LKU4, B5VT34, C7GJ84, C8ZIP9, G2WP50, N1P1H9
      Conserved Domains (1) summary
      PTZ00069
      Location:1 → 282
      PTZ00069; 60S ribosomal protein L5; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P26321.4

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