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    VPS16 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856062, updated on 11-Sep-2024

    Summary

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    Official Symbol
    VPS16
    Primary source
    SGD:S000005966
    Locus tag
    YPL045W
    See related
    AllianceGenome:SGD:S000005966; FungiDB:YPL045W; VEuPathDB:YPL045W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CVT15; SVL6; VAM9; VPT16
    Summary
    Contributes to phosphatidylinositol binding activity. Involved in several processes, including Golgi to endosome transport; late endosome to vacuole transport; and vacuole fusion, non-autophagic. Located in fungal-type vacuole membrane. Part of CORVET complex and HOPS complex. Human ortholog(s) of this gene implicated in dystonia. Orthologous to human VPS16 (VPS16 core subunit of CORVET and HOPS complexes). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (467260..469656)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene SAGA histone acetyltransferase complex subunit SGF11 Neighboring gene elongin C Neighboring gene mRNA-binding ribosome biosynthesis protein NOP4 Neighboring gene cyclin-dependent serine/threonine protein kinase SSN3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations that affect vacuole biogenesis inhibit proliferation of the endoplasmic reticulum in Saccharomyces cerevisiae. Koning AJ, et al. Genetics, 2002 Apr. PMID 11973291, Free PMC Article
    2. The VPS16 gene product associates with a sedimentable protein complex and is essential for vacuolar protein sorting in yeast. Horazdovsky BF, et al. J Biol Chem, 1993 Mar 5. PMID 8444873
    3. Iron sequestration by the yeast vacuole. A study with vacuolar mutants of Saccharomyces cerevisiae. Bode HP, et al. Eur J Biochem, 1995 Mar 1. PMID 7705347
    4. Sec17/Sec18 can support membrane fusion without help from completion of SNARE zippering. Song H, et al. Elife, 2021 May 4. PMID 33944780, Free PMC Article
    5. Defects associated with mitochondrial DNA damage can be mitigated by increased vacuolar pH in Saccharomyces cerevisiae. Garipler G, et al. Genetics, 2013 May. PMID 23502676, Free PMC Article

    See all (104) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to phosphatidylinositol binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to endosome transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in late endosome to vacuole transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of SNARE complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vacuole fusion, non-autophagic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vacuole fusion, non-autophagic IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vacuole fusion, non-autophagic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuole organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vacuole organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle tethering IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CORVET complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of HOPS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of HOPS complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tethering complex subunit VPS16
    NP_015280.1
    • Subunit of the HOPS and the CORVET complexes; part of the Class C Vps complex essential for membrane docking and fusion at Golgi-to-endosome and endosome-to-vacuole protein transport stages

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      467260..469656
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183859.1 → NP_015280.1  TPA: tethering complex subunit VPS16 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015280.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3W9, Q03078, Q03308
      UniProtKB/TrEMBL
      G2WPD3, N1NVI1
      Conserved Domains (2) summary
      pfam04841
      Location:4 → 379
      Vps16_N; Vps16, N-terminal region
      pfam04840
      Location:478 → 798
      Vps16_C; Vps16, C-terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03308.2

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