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    Ndrg4 N-myc downstream regulated gene 4 [ Mus musculus (house mouse) ]

    Gene ID: 234593, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Ndrg4provided by MGI
    Official Full Name
    N-myc downstream regulated gene 4provided by MGI
    Primary source
    MGI:MGI:2384590
    See related
    Ensembl:ENSMUSG00000036564 AllianceGenome:MGI:2384590
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ndr4; SMAP-8; Ndr1-rs; D8Bwg1337e
    Summary
    Involved in several processes, including regulation of endocytic recycling; vesicle docking; and visual learning. Located in cell projection membrane and cytoplasm. Is expressed in several structures, including genitourinary system; gut; nervous system; respiratory system; and retina. Orthologous to human NDRG4 (NDRG family member 4). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 385.8), cerebellum adult (RPKM 322.6) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ndrg4 in Genome Data Viewer
    Location:
    8 D1; 8 47.12 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (96403602..96441584)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (95676974..95714956)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42037 Neighboring gene gem (nuclear organelle) associated protein 8 pseudogene Neighboring gene predicted gene, 51585 Neighboring gene SET domain containing 6 Neighboring gene CCR4-NOT transcription complex, subunit 1 Neighboring gene predicted gene, 26493

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NDRG4, an early detection marker for colorectal cancer, is specifically expressed in enteric neurons. Vaes N, et al. Neurogastroenterol Motil, 2017 Sep. PMID 28524415
    2. Uterine Expression of NDRG4 Is Induced by Estrogen and Up-Regulated during Embryo Implantation Process in Mice. Yang Q, et al. PLoS One, 2016. PMID 27175791, Free PMC Article
    3. Postnatal lethality and abnormal development of foregut and spleen in Ndrg4 mutant mice. Qu X, et al. Biochem Biophys Res Commun, 2016 Feb 12. PMID 26801554, Free PMC Article
    4. N-myc downstream-regulated gene 4, up-regulated by tumor necrosis factor-α and nuclear factor kappa B, aggravates cardiac ischemia/reperfusion injury by inhibiting reperfusion injury salvage kinase pathway. Xing Y, et al. Basic Res Cardiol, 2016 Mar. PMID 26780215
    5. NDRG4 is required for cell cycle progression and survival in glioblastoma cells. Schilling SH, et al. J Biol Chem, 2009 Sep 11. PMID 19592488, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NDRG4 is exclusively expressed by central, peripheral and enteric neurons/nerves, suggesting a neuronal-specific role of this protein
      Title: NDRG4, an early detection marker for colorectal cancer, is specifically expressed in enteric neurons.
    2. NDRG4 might play an important role during early pregnancy.
      Title: Uterine Expression of NDRG4 Is Induced by Estrogen and Up-Regulated during Embryo Implantation Process in Mice.
    3. up-regulation of NDRG4 aggravates myocardial ischemia/reperfusion injury by inhibiting activation of the RISK pathway
      Title: N-myc downstream-regulated gene 4, up-regulated by tumor necrosis factor-α and nuclear factor kappa B, aggravates cardiac ischemia/reperfusion injury by inhibiting reperfusion injury salvage kinase pathway.
    4. Availability of the conditional allele for Ndrg4 should facilitate further detailed analyses of the potential roles of Ndrg4 in gut development, nervous system and immune system.
      Title: Postnatal lethality and abnormal development of foregut and spleen in Ndrg4 mutant mice.
    5. Bves and NDRG4 regulate directional epicardial cell migration through autocrine extracellular matrix deposition.
      Title: Bves and NDRG4 regulate directional epicardial cell migration through autocrine extracellular matrix deposition.
    6. NDRG4 contributes to the maintenance of intracerebral BDNF levels within the normal range
      Title: NDRG4 protein-deficient mice exhibit spatial learning deficits and vulnerabilities to cerebral ischemia.
    7. NDRG4 is required for cell cycle progression and survival, thereby diverging in function from its tumor suppressive family member NDRG2 in astrocytes and GBM cells
      Title: NDRG4 is required for cell cycle progression and survival in glioblastoma cells.
    8. These expression patterns demonstrated the cell type-specific and ubiquitous localization of the NDRG family proteins. Each NDRG may play a partially redundant role in specific cells in the brain.
      Title: Differential expression patterns of NDRG family proteins in the central nervous system.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (6)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC7067

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell migration involved in heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of platelet-derived growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of platelet-derived growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of smooth muscle cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of endocytic recycling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle docking IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in visual learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein NDRG4
    Names
    N-myc downstream regulated 1, related sequence
    N-myc downstream-regulated gene 4 protein
    protein Ndr4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195006.2 → NP_001181935.1  protein NDRG4 isoform A

      See identical proteins and their annotated locations for NP_001181935.1

      Status: VALIDATED

      Source sequence(s)
      AC113951
      Consensus CDS
      CCDS57634.1
      UniProtKB/Swiss-Prot
      Q6ZPW3, Q8BTG7, Q923D7
      Related
      ENSMUSP00000072883.8, ENSMUST00000073139.14
      Conserved Domains (1) summary
      pfam03096
      Location:8 → 290
      Ndr; Ndr family

    2. NM_001372421.1 → NP_001359350.1  protein NDRG4 isoform C

      Status: VALIDATED

      Source sequence(s)
      AC113951
      Conserved Domains (1) summary
      pfam03096
      Location:60 → 342
      Ndr; Ndr family

    3. NM_001372423.1 → NP_001359352.1  protein NDRG4 isoform C

      Status: VALIDATED

      Source sequence(s)
      AC113951
      Consensus CDS
      CCDS90441.1
      Related
      ENSMUSP00000036226.8, ENSMUST00000041318.14
      Conserved Domains (1) summary
      pfam03096
      Location:60 → 342
      Ndr; Ndr family

    4. NM_001372425.1 → NP_001359354.1  protein NDRG4 isoform D

      Status: VALIDATED

      Source sequence(s)
      AC113951
      Conserved Domains (1) summary
      pfam03096
      Location:60 → 342
      Ndr; Ndr family

    5. NM_001372426.1 → NP_001359355.1  protein NDRG4 isoform D

      Status: VALIDATED

      Source sequence(s)
      AC113951
      Conserved Domains (1) summary
      pfam03096
      Location:60 → 342
      Ndr; Ndr family

    6. NM_001372427.1 → NP_001359356.1  protein NDRG4 isoform E

      Status: VALIDATED

      Source sequence(s)
      AC113951
      Conserved Domains (1) summary
      pfam03096
      Location:40 → 322
      Ndr; Ndr family

    7. NM_001372428.1 → NP_001359357.1  protein NDRG4 isoform E

      Status: VALIDATED

      Source sequence(s)
      AC113951
      Conserved Domains (1) summary
      pfam03096
      Location:40 → 322
      Ndr; Ndr family

    8. NM_001372429.1 → NP_001359358.1  protein NDRG4 isoform F

      Status: VALIDATED

      Source sequence(s)
      AC113951
      Conserved Domains (1) summary
      pfam03096
      Location:40 → 322
      Ndr; Ndr family

    9. NM_001372430.1 → NP_001359359.1  protein NDRG4 isoform G

      Status: VALIDATED

      Source sequence(s)
      AC113951
      Conserved Domains (1) summary
      pfam03096
      Location:40 → 306
      Ndr; Ndr family

    10. NM_001372431.1 → NP_001359360.1  protein NDRG4 isoform H

      Status: VALIDATED

      Source sequence(s)
      AC113951
      Conserved Domains (1) summary
      pfam03096
      Location:8 → 289
      Ndr; Ndr family

    11. NM_001372432.1 → NP_001359361.1  protein NDRG4 isoform I

      Status: VALIDATED

      Source sequence(s)
      AC113951
      Conserved Domains (1) summary
      pfam03096
      Location:8 → 289
      Ndr; Ndr family

    12. NM_001372433.1 → NP_001359362.1  protein NDRG4 isoform J

      Status: VALIDATED

      Source sequence(s)
      AC113951
      Conserved Domains (1) summary
      pfam03096
      Location:8 → 274
      Ndr; Ndr family

    13. NM_001372434.1 → NP_001359363.1  protein NDRG4 isoform K

      Status: VALIDATED

      Source sequence(s)
      AC113951
      Conserved Domains (1) summary
      pfam03096
      Location:8 → 269
      Ndr; Ndr family

    14. NM_001372435.1 → NP_001359364.1  protein NDRG4 isoform L

      Status: VALIDATED

      Source sequence(s)
      AC113951
      Conserved Domains (1) summary
      pfam03096
      Location:8 → 261
      Ndr; Ndr family

    15. NM_145602.4 → NP_663577.1  protein NDRG4 isoform B

      See identical proteins and their annotated locations for NP_663577.1

      Status: VALIDATED

      Source sequence(s)
      AC113951
      Consensus CDS
      CCDS22565.1
      UniProtKB/Swiss-Prot
      Q8BTG7
      Related
      ENSMUSP00000079495.8, ENSMUST00000080666.8
      Conserved Domains (1) summary
      pfam03096
      Location:8 → 290
      Ndr; Ndr family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      96403602..96441584
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BTG7.1 GenPept UniProtKB/Swiss-Prot:Q8BTG7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools