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    Saysd1 SAYSVFN motif domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 67509, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Saysd1provided by MGI
    Official Full Name
    SAYSVFN motif domain containing 1provided by MGI
    Primary source
    MGI:MGI:1914759
    See related
    Ensembl:ENSMUSG00000045107 AllianceGenome:MGI:1914759
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810063B07Rik; 4930488P03Rik
    Summary
    Predicted to enable UFM1-modified protein reader activity. Predicted to be involved in protein quality control for misfolded or incompletely synthesized proteins and rescue of stalled ribosome. Is active in endoplasmic reticulum. Orthologous to human SAYSD1 (SAYSVFN motif domain containing 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in testis adult (RPKM 87.7), colon adult (RPKM 6.4) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Saysd1 in Genome Data Viewer
    Location:
    14 11.4 cM; 14 A3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (20125704..20133240, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (20075636..20083172, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene DNA segment, Chr 14, ERATO Doi 670, expressed Neighboring gene STARR-seq mESC enhancer starr_36086 Neighboring gene guanine nucleotide binding protein (G protein), gamma 2 Neighboring gene STARR-seq mESC enhancer starr_36089 Neighboring gene VISTA enhancer mm1498 Neighboring gene STARR-seq mESC enhancer starr_36096 Neighboring gene STARR-seq mESC enhancer starr_36097 Neighboring gene STARR-seq mESC enhancer starr_36099 Neighboring gene predicted gene, 41104 Neighboring gene predicted gene, 52125

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The UFMylated ribosome-recognition protein SAYSD1 is predominantly expressed in spermatids but is dispensable for fertility in mice. Chang L, et al. Biochem Biophys Res Commun, 2023 Sep 24. PMID 37419030
    2. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article
    3. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The UFMylated ribosome-recognition protein SAYSD1 is predominantly expressed in spermatids but is dispensable for fertility in mice.
      Title: The UFMylated ribosome-recognition protein SAYSD1 is predominantly expressed in spermatids but is dispensable for fertility in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables UFM1-modified protein reader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables UFM1-modified protein reader activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein quality control for misfolded or incompletely synthesized proteins ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein quality control for misfolded or incompletely synthesized proteins ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in rescue of stalled ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rescue of stalled ribosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SAYSvFN domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026209.1 → NP_080485.1  SAYSvFN domain-containing protein 1

      See identical proteins and their annotated locations for NP_080485.1

      Status: VALIDATED

      Source sequence(s)
      AK031748, BC027644, BY096351, CJ320425
      Consensus CDS
      CCDS49406.1
      UniProtKB/Swiss-Prot
      Q8K190
      Related
      ENSMUSP00000055382.5, ENSMUST00000059666.6
      Conserved Domains (1) summary
      pfam10260
      Location:113 → 165
      SAYSvFN; Uncharacterized conserved domain (SAYSvFN)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      20125704..20133240 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316166.3 → XP_017171655.1  SAYSvFN domain-containing protein 1 isoform X1

      Conserved Domains (1) summary
      pfam10260
      Location:61 → 113
      SAYSvFN; Uncharacterized conserved domain (SAYSvFN)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K190.1 GenPept UniProtKB/Swiss-Prot:Q8K190

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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