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    ARHGEF12 Rho guanine nucleotide exchange factor 12 [ Homo sapiens (human) ]

    Gene ID: 23365, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ARHGEF12provided by HGNC
    Official Full Name
    Rho guanine nucleotide exchange factor 12provided by HGNC
    Primary source
    HGNC:HGNC:14193
    See related
    Ensembl:ENSG00000196914 MIM:604763; AllianceGenome:HGNC:14193
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LARG; PRO2792
    Summary
    Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
    Expression
    Ubiquitous expression in kidney (RPKM 33.3), thyroid (RPKM 28.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ARHGEF12 in Genome Data Viewer
    Location:
    11q23.3
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (120336413..120489937)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (120360067..120513690)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (120207122..120360646)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369531 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:120146894-120147083 Neighboring gene POU class 2 homeobox 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:120177487-120177989 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:120176405-120176922 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_19560 and experimental_19565 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 11:120184592 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:120193421-120193580 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3990 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3989 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 11:120195689 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3991 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:120224214-120224428 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 11:120249395 Neighboring gene TLC domain containing 5 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 11:120288060 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 11:120305787 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 11:120306759 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 11:120313899 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 11:120345004 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 11:120350393 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 11:120356317 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5637 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5638 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3992 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3993 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:120386966-120387568 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:120387569-120388170 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:120402421-120402957 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:120418648-120419393 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:120435257-120435837 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:120435838-120436417 Neighboring gene uncharacterized LOC107984400 Neighboring gene glutamate ionotropic receptor kainate type subunit 4 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:120479691-120480414 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:120480713-120481226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5639 Neighboring gene elongin C pseudogene 22

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia. Kourlas PJ, et al. Proc Natl Acad Sci U S A, 2000 Feb 29. PMID 10681437, Free PMC Article
    2. Real-time NMR study of guanine nucleotide exchange and activation of RhoA by PDZ-RhoGEF. Gasmi-Seabrook GM, et al. J Biol Chem, 2010 Feb 19. PMID 20018869, Free PMC Article
    3. LARG links histamine-H1-receptor-activated Gq to Rho-GTPase-dependent signaling pathways. Pfreimer M, et al. Cell Signal, 2012 Mar. PMID 22100544
    4. LARG at chromosome 11q23 has functional characteristics of a tumor suppressor in human breast and colorectal cancer. Ong DC, et al. Oncogene, 2009 Nov 26. PMID 19734946, Free PMC Article
    5. Leukemia-associated RhoGEF (LARG) is a novel RhoGEF in cytokinesis and required for the proper completion of abscission. Martz MK, et al. Mol Biol Cell, 2013 Sep. PMID 23885121, Free PMC Article

    See all (103) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Targeting ARHGEF12 promotes neuroblastoma differentiation, MYCN degradation, and reduces tumorigenicity.
      Title: Targeting ARHGEF12 promotes neuroblastoma differentiation, MYCN degradation, and reduces tumorigenicity.
    2. ArhGEF12 activates Rap1A and not RhoA in human dermal microvascular endothelial cells to reduce tumor necrosis factor-induced leak.
      Title: ArhGEF12 activates Rap1A and not RhoA in human dermal microvascular endothelial cells to reduce tumor necrosis factor-induced leak.
    3. ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients.
      Title: ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients.
    4. Data show that phosphorylation of ribosomal protein S6 kinase 2 (RSK2) at threonine 577 is essential for leukemia-associated RhoGEF (LARG)-dependent Rho GTPase activation.
      Title: RSK2 drives cell motility by serine phosphorylation of LARG and activation of Rho GTPases.
    5. We studied the function of LARG in murine and human megakaryocytes and platelets with Larg knockout (KO), shRNA-mediated knockdown and small molecule-mediated inhibition. We found that LARG is important for human, but not murine, megakaryocyte maturation.
      Title: Leukaemia-associated Rho guanine nucleotide exchange factor (LARG) plays an agonist specific role in platelet function through RhoA activation.
    6. that leukemia-associated Rho guanine-nucleotide exchange factor can be directly phosphorylated by cyclin-dependent kinase 1
      Title: Mitotic-dependent phosphorylation of leukemia-associated RhoGEF (LARG) by Cdk1.
    7. Two related guanine nucleotide exchange factors (GEFs), PDZ-RhoGEF and leukemia-associated RhoGEF (LARG), use their PDZ domains to bind class B plexins and play critical roles in signaling.
      Title: Secondary PDZ domain-binding site on class B plexins enhances the affinity for PDZ-RhoGEF.
    8. this study identified a novel association between IOP and ARHGEF12.
      Title: ARHGEF12 influences the risk of glaucoma by increasing intraocular pressure.
    9. TGF-beta regulates LARG and GEF-H1 during epithelial-mesenchymal transition to affect stiffening response to force and cell invasion.
      Title: TGF-β regulates LARG and GEF-H1 during EMT to affect stiffening response to force and cell invasion.
    10. LARG is a novel and temporally distinct Rho Guanine Nucleotide Exchange Factor required for completion of abscission.
      Title: Leukemia-associated RhoGEF (LARG) is a novel RhoGEF in cytokinesis and required for the proper completion of abscission.
    Submit: New GeneRIF Correction See all GeneRIFs (33)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Common variants near ABCA1, AFAP1 and GMDS confer risk of primary open-angle glaucoma.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of Rho guanine nucleotide exchange factor 12 (ARHGEF12) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with Rho guanine nucleotide exchange factor (GEF) 12 (ARHGEF12) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0382, DKFZp686O2372

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 12
    Names
    KMT2A/ARHGEF12 fusion protein
    Rho guanine nucleotide exchange factor (GEF) 12
    leukemia-associated RhoGEF
    leukemia-associated rho guanine nucleotide exchange factor

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027960.1 RefSeqGene

      Range
      4505..158029
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001198665.2 → NP_001185594.1  rho guanine nucleotide exchange factor 12 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AF180681, AK304316, AP000758, AP001150, BC063117
      Consensus CDS
      CCDS55794.1
      UniProtKB/TrEMBL
      A0A2X0SFF5
      Related
      ENSP00000349056.3, ENST00000356641.7
      Conserved Domains (4) summary
      cd08754
      Location:330 → 551
      RGS_LARG; Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)
      cd00992
      Location:52 → 126
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13390
      Location:976 → 1113
      PH_LARG; Leukemia-associated Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00621
      Location:772 → 957
      RhoGEF; RhoGEF domain

    2. NM_001301084.2 → NP_001288013.1  rho guanine nucleotide exchange factor 12 isoform 3

      See identical proteins and their annotated locations for NP_001288013.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate first exon and initiates translation at a downstream AUG compared to variant 1. Thd resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AF180681, AP000659, AP000758, BX647785
      Consensus CDS
      CCDS76487.1
      UniProtKB/TrEMBL
      A0A2X0SFF5, E9PMR6
      Related
      ENSP00000432984.1, ENST00000532993.5
      Conserved Domains (4) summary
      cd08754
      Location:246 → 467
      RGS_LARG; Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)
      cd00992
      Location:2 → 42
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13390
      Location:892 → 1029
      PH_LARG; Leukemia-associated Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00621
      Location:688 → 873
      RhoGEF; RhoGEF domain

    3. NM_015313.3 → NP_056128.1  rho guanine nucleotide exchange factor 12 isoform 1

      See identical proteins and their annotated locations for NP_056128.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AF180681, AK304316, AP000758, AP001150, BC063117
      Consensus CDS
      CCDS41727.1
      UniProtKB/Swiss-Prot
      O15086, Q6P526, Q9NZN5
      UniProtKB/TrEMBL
      A0A2X0SFF5
      Related
      ENSP00000380942.2, ENST00000397843.7
      Conserved Domains (4) summary
      cd08754
      Location:349 → 570
      RGS_LARG; Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)
      cd00992
      Location:71 → 145
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13390
      Location:995 → 1132
      PH_LARG; Leukemia-associated Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00621
      Location:791 → 976
      RhoGEF; RhoGEF domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      120336413..120489937
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006718805.4 → XP_006718868.1  rho guanine nucleotide exchange factor 12 isoform X1

      UniProtKB/TrEMBL
      A0A2X0SFF5
      Conserved Domains (4) summary
      cd08754
      Location:324 → 545
      RGS_LARG; Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)
      cd00992
      Location:71 → 145
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13390
      Location:970 → 1107
      PH_LARG; Leukemia-associated Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00621
      Location:766 → 951
      RhoGEF; RhoGEF domain

    2. XM_047426659.1 → XP_047282615.1  rho guanine nucleotide exchange factor 12 isoform X2

      UniProtKB/TrEMBL
      A0A2X0SFF5

    3. XM_047426661.1 → XP_047282617.1  rho guanine nucleotide exchange factor 12 isoform X5

      UniProtKB/TrEMBL
      A0A2X0SFF5

    4. XM_047426660.1 → XP_047282616.1  rho guanine nucleotide exchange factor 12 isoform X3

      UniProtKB/TrEMBL
      A0A2X0SFF5

    5. XM_017017420.2 → XP_016872909.1  rho guanine nucleotide exchange factor 12 isoform X4

      UniProtKB/TrEMBL
      A0A2X0SFF5
      Conserved Domains (4) summary
      cd08754
      Location:290 → 511
      RGS_LARG; Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)
      smart00325
      Location:732 → 917
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00992
      Location:52 → 126
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13390
      Location:936 → 1073
      PH_LARG; Leukemia-associated Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain

    6. XM_047426662.1 → XP_047282618.1  rho guanine nucleotide exchange factor 12 isoform X7

      UniProtKB/TrEMBL
      A0A2X0SFF5

    7. XM_047426665.1 → XP_047282621.1  rho guanine nucleotide exchange factor 12 isoform X6

      UniProtKB/TrEMBL
      A0A2X0SFF5, E9PMR6

    8. XM_011542720.3 → XP_011541022.1  rho guanine nucleotide exchange factor 12 isoform X6

      See identical proteins and their annotated locations for XP_011541022.1

      UniProtKB/TrEMBL
      A0A2X0SFF5, E9PMR6
      Conserved Domains (4) summary
      cd08754
      Location:246 → 467
      RGS_LARG; Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)
      cd00992
      Location:2 → 42
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13390
      Location:892 → 1029
      PH_LARG; Leukemia-associated Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00621
      Location:688 → 873
      RhoGEF; RhoGEF domain

    9. XM_047426666.1 → XP_047282622.1  rho guanine nucleotide exchange factor 12 isoform X8

      UniProtKB/TrEMBL
      A0A2X0SFF5

    10. XM_047426663.1 → XP_047282619.1  rho guanine nucleotide exchange factor 12 isoform X6

      UniProtKB/TrEMBL
      A0A2X0SFF5, E9PMR6

    11. XM_047426667.1 → XP_047282623.1  rho guanine nucleotide exchange factor 12 isoform X9

      UniProtKB/TrEMBL
      A0A2X0SFF5

    12. XM_047426668.1 → XP_047282624.1  rho guanine nucleotide exchange factor 12 isoform X8

      UniProtKB/TrEMBL
      A0A2X0SFF5

    13. XM_017017421.2 → XP_016872910.1  rho guanine nucleotide exchange factor 12 isoform X6

      UniProtKB/TrEMBL
      A0A2X0SFF5, E9PMR6
      Conserved Domains (4) summary
      cd08754
      Location:246 → 467
      RGS_LARG; Regulator of G protein signaling (RGS) domain found in the leukemia-associated Rho guanine nucleotide exchange factor (RhoGEF) protein (LARG)
      cd00992
      Location:2 → 42
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13390
      Location:892 → 1029
      PH_LARG; Leukemia-associated Rho guanine nucleotide exchange factor Pleckstrin homology (PH) domain
      pfam00621
      Location:688 → 873
      RhoGEF; RhoGEF domain

    14. XM_047426670.1 → XP_047282626.1  rho guanine nucleotide exchange factor 12 isoform X10

      UniProtKB/TrEMBL
      A0A2X0SFF5

    15. XM_047426664.1 → XP_047282620.1  rho guanine nucleotide exchange factor 12 isoform X6

      UniProtKB/TrEMBL
      A0A2X0SFF5, E9PMR6

    16. XM_047426669.1 → XP_047282625.1  rho guanine nucleotide exchange factor 12 isoform X8

      UniProtKB/TrEMBL
      A0A2X0SFF5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      120360067..120513690
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368208.1 → XP_054224183.1  rho guanine nucleotide exchange factor 12 isoform X6

      UniProtKB/TrEMBL
      A0A2X0SFF5, E9PMR6

    2. XM_054368210.1 → XP_054224185.1  rho guanine nucleotide exchange factor 12 isoform X6

      UniProtKB/TrEMBL
      A0A2X0SFF5, E9PMR6

    3. XM_054368215.1 → XP_054224190.1  rho guanine nucleotide exchange factor 12 isoform X9

      UniProtKB/TrEMBL
      A0A2X0SFF5

    4. XM_054368214.1 → XP_054224189.1  rho guanine nucleotide exchange factor 12 isoform X8

      UniProtKB/TrEMBL
      A0A2X0SFF5

    5. XM_054368216.1 → XP_054224191.1  rho guanine nucleotide exchange factor 12 isoform X8

      UniProtKB/TrEMBL
      A0A2X0SFF5

    6. XM_054368203.1 → XP_054224178.1  rho guanine nucleotide exchange factor 12 isoform X1

      UniProtKB/TrEMBL
      A0A2X0SFF5

    7. XM_054368204.1 → XP_054224179.1  rho guanine nucleotide exchange factor 12 isoform X2

      UniProtKB/TrEMBL
      A0A2X0SFF5

    8. XM_054368207.1 → XP_054224182.1  rho guanine nucleotide exchange factor 12 isoform X5

      UniProtKB/TrEMBL
      A0A2X0SFF5

    9. XM_054368205.1 → XP_054224180.1  rho guanine nucleotide exchange factor 12 isoform X3

      UniProtKB/TrEMBL
      A0A2X0SFF5

    10. XM_054368206.1 → XP_054224181.1  rho guanine nucleotide exchange factor 12 isoform X4

      UniProtKB/TrEMBL
      A0A2X0SFF5

    11. XM_054368209.1 → XP_054224184.1  rho guanine nucleotide exchange factor 12 isoform X7

      UniProtKB/TrEMBL
      A0A2X0SFF5

    12. XM_054368213.1 → XP_054224188.1  rho guanine nucleotide exchange factor 12 isoform X6

      UniProtKB/TrEMBL
      A0A2X0SFF5, E9PMR6

    13. XM_054368212.1 → XP_054224187.1  rho guanine nucleotide exchange factor 12 isoform X6

      UniProtKB/TrEMBL
      A0A2X0SFF5, E9PMR6

    14. XM_054368218.1 → XP_054224193.1  rho guanine nucleotide exchange factor 12 isoform X10

      UniProtKB/TrEMBL
      A0A2X0SFF5

    15. XM_054368211.1 → XP_054224186.1  rho guanine nucleotide exchange factor 12 isoform X6

      UniProtKB/TrEMBL
      A0A2X0SFF5, E9PMR6

    16. XM_054368217.1 → XP_054224192.1  rho guanine nucleotide exchange factor 12 isoform X8

      UniProtKB/TrEMBL
      A0A2X0SFF5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NZN5.1 GenPept UniProtKB/Swiss-Prot:Q9NZN5

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