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    ADGRG4 adhesion G protein-coupled receptor G4 [ Homo sapiens (human) ]

    Gene ID: 139378, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ADGRG4provided by HGNC
    Official Full Name
    adhesion G protein-coupled receptor G4provided by HGNC
    Primary source
    HGNC:HGNC:18992
    See related
    Ensembl:ENSG00000156920 MIM:301085; AllianceGenome:HGNC:18992
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PGR17; GPR112; RP1-299I16
    Summary
    This gene encodes a G-protein coupled receptor belonging to a large family of diverse integral membrane proteins that participate in various physiological functions. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The ligand for this family member is unknown, and it is therefore an orphan receptor. This receptor is known to be expressed in normal enterochromaffin cells and in gastrointestinal neuroendocrine carcinoma cells, and it is therefore considered to be a novel biomarker or target for immunotherapy. [provided by RefSeq, May 2010]
    Expression
    Biased expression in duodenum (RPKM 1.3), small intestine (RPKM 0.8) and 2 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ADGRG4 in Genome Data Viewer
    Location:
    Xq26.3
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (136300963..136416890)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (134609302..134725270)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (135383122..135499049)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 1893 Neighboring gene MAP7 domain containing 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21026 Neighboring gene serine/threonine kinase 24 pseudogene 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chrX:135434931-135436130 Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:135468612-135469811 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21027 Neighboring gene HIV-1 Tat specific factor 1 Neighboring gene bombesin receptor subtype 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Exome sequencing identifies ADGRG4 G-protein-coupled receptors gene as a novel cancer biomarker in ovarian cancer patients from North India. Sharma M, et al. J Biochem Mol Toxicol, 2024 Mar. PMID 38462741
    2. The dimerized pentraxin-like domain of the adhesion G protein-coupled receptor 112 (ADGRG4) suggests function in sensing mechanical forces. Kieslich B, et al. J Biol Chem, 2023 Dec. PMID 37863265, Free PMC Article
    3. Getting from A to B-exploring the activation motifs of the class B adhesion G protein-coupled receptor subfamily G member 4/GPR112. Peeters MC, et al. FASEB J, 2016 May. PMID 26823453
    4. Novel markers for enterochromaffin cells and gastrointestinal neuroendocrine carcinomas. Leja J, et al. Mod Pathol, 2009 Feb. PMID 18953328
    5. Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. Fredriksson R, et al. FEBS Lett, 2002 Nov 20. PMID 12435584

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Exome sequencing identifies ADGRG4 G-protein-coupled receptors gene as a novel cancer biomarker in ovarian cancer patients from North India.
      Title: Exome sequencing identifies ADGRG4 G-protein-coupled receptors gene as a novel cancer biomarker in ovarian cancer patients from North India.
    2. The dimerized pentraxin-like domain of the adhesion G protein-coupled receptor 112 (ADGRG4) suggests function in sensing mechanical forces.
      Title: The dimerized pentraxin-like domain of the adhesion G protein-coupled receptor 112 (ADGRG4) suggests function in sensing mechanical forces.
    3. This study described the structure-function relationship of adhesion G protein-coupled receptors (ADGRs) using ADGRGr as a model receptor.
      Title: Getting from A to B-exploring the activation motifs of the class B adhesion G protein-coupled receptor subfamily G member 4/GPR112.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp781E1948

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    adhesion G-protein coupled receptor G4
    Names
    G protein-coupled receptor 112
    probable G-protein coupled receptor 112

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021219.1 RefSeqGene

      Range
      5001..120928
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_153834.4 → NP_722576.3  adhesion G-protein coupled receptor G4 precursor

      See identical proteins and their annotated locations for NP_722576.3

      Status: REVIEWED

      Source sequence(s)
      AL161778, AY140954, AY882585
      Consensus CDS
      CCDS35409.1
      UniProtKB/Swiss-Prot
      A2A2J1, A2A2J2, Q5EGP2, Q86SM6, Q8IZF6
      Related
      ENSP00000377699.1, ENST00000394143.6
      Conserved Domains (4) summary
      pfam00002
      Location:2743 → 2982
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam01825
      Location:2684 → 2727
      GPS; GPCR proteolysis site, GPS, motif
      pfam09786
      Location:1668 → 1909
      CytochromB561_N; Cytochrome B561, N terminal
      cl22861
      Location:28 → 210
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      136300963..136416890
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011531269.3 → XP_011529571.1  adhesion G-protein coupled receptor G4 isoform X1

      See identical proteins and their annotated locations for XP_011529571.1

      UniProtKB/Swiss-Prot
      A2A2J1, A2A2J2, Q5EGP2, Q86SM6, Q8IZF6
      Related
      ENSP00000377697.1, ENST00000394141.1
      Conserved Domains (4) summary
      pfam00002
      Location:2743 → 2982
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam01825
      Location:2684 → 2727
      GPS; GPCR proteolysis site, GPS, motif
      pfam09786
      Location:1668 → 1909
      CytochromB561_N; Cytochrome B561, N terminal
      cl22861
      Location:28 → 210
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    2. XM_047441830.1 → XP_047297786.1  adhesion G-protein coupled receptor G4 isoform X2

    3. XM_047441831.1 → XP_047297787.1  adhesion G-protein coupled receptor G4 isoform X4

    4. XM_011531271.3 → XP_011529573.1  adhesion G-protein coupled receptor G4 isoform X3

      Conserved Domains (4) summary
      pfam00002
      Location:2680 → 2919
      7tm_2; 7 transmembrane receptor (Secretin family)
      pfam01825
      Location:2621 → 2664
      GPS; GPCR proteolysis site, GPS, motif
      pfam09786
      Location:1605 → 1846
      CytochromB561_N; Cytochrome B561, N terminal
      cl22861
      Location:2 → 147
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      134609302..134725270
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326479.1 → XP_054182454.1  adhesion G-protein coupled receptor G4 isoform X1

      UniProtKB/Swiss-Prot
      A2A2J1, A2A2J2, Q5EGP2, Q86SM6, Q8IZF6

    2. XM_054326480.1 → XP_054182455.1  adhesion G-protein coupled receptor G4 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IZF6.2 GenPept UniProtKB/Swiss-Prot:Q8IZF6

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