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    Cisd3 CDGSH iron sulfur domain 3 [ Mus musculus (house mouse) ]

    Gene ID: 217149, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Cisd3provided by MGI
    Official Full Name
    CDGSH iron sulfur domain 3provided by MGI
    Primary source
    MGI:MGI:101788
    See related
    Ensembl:ENSMUSG00000078695 AllianceGenome:MGI:101788
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mel13; Mel-13
    Summary
    Predicted to enable 2 iron, 2 sulfur cluster binding activity and metal ion binding activity. Predicted to be involved in protein maturation by [2Fe-2S] cluster transfer. Located in mitochondrion. Orthologous to human CISD3 (CDGSH iron sulfur domain 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in large intestine adult (RPKM 67.3), duodenum adult (RPKM 51.1) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cisd3 in Genome Data Viewer
    Location:
    11 D; 11 61.06 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (97576291..97579451)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (97685465..97688625)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11613 Neighboring gene STARR-positive B cell enhancer ABC_E3996 Neighboring gene STARR-seq mESC enhancer starr_30629 Neighboring gene myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6 Neighboring gene microRNA 6927 Neighboring gene STARR-positive B cell enhancer ABC_E7050 Neighboring gene polycomb group ring finger 2 Neighboring gene STARR-positive B cell enhancer ABC_E7051 Neighboring gene nuclear encoded tRNA asparagine 8 (anticodon GTT)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. FGF4 improves hepatocytes ferroptosis in autoimmune hepatitis mice via activation of CISD3. Jiang H, et al. Int Immunopharmacol, 2023 Mar. PMID 36702076
    2. Cloning and characterization of two transcripts generated from the mel-13 gene positioned adjacent to the mammalian Polycomb group-related gene mel-18. Tetsu O, et al. Biochim Biophys Acta, 1996 Mar 1. PMID 8597592
    3. Nucleotide sequence of bup, an upstream gene in the bmi-1 proviral insertion locus. Haupt Y, et al. Mol Biol Rep, 1992 Nov. PMID 1287475
    4. Activation and negative selection of functionally distinct subsets of antibody-secreting cells by influenza hemagglutinin as a viral and a neo-self antigen. Caton AJ, et al. J Exp Med, 1996 Jan 1. PMID 8551216, Free PMC Article
    5. Mutagenic transgene insertion into a region of high gene density and multiple linkage disruptions on mouse chromosome 11. Kleiter N, et al. Cytogenet Genome Res, 2002. PMID 12438746

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FGF4 improves hepatocytes ferroptosis in autoimmune hepatitis mice via activation of CISD3.
      Title: FGF4 improves hepatocytes ferroptosis in autoimmune hepatitis mice via activation of CISD3.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 2 iron, 2 sulfur cluster binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein maturation by [2Fe-2S] cluster transfer IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein maturation by [2Fe-2S] cluster transfer ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CDGSH iron-sulfur domain-containing protein 3, mitochondrial
    Names
    melanoma nuclear protein 13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085500.3 → NP_001078969.2  CDGSH iron-sulfur domain-containing protein 3, mitochondrial isoform 2 precursor

      See identical proteins and their annotated locations for NP_001078969.2

      Status: VALIDATED

      Source sequence(s)
      AA987107, AI414532, BC056217
      Consensus CDS
      CCDS48896.1
      UniProtKB/Swiss-Prot
      B1AR11, B1AR12, B1AR13
      UniProtKB/TrEMBL
      Z4YKM2
      Related
      ENSMUSP00000103209.3, ENSMUST00000107583.3
      Conserved Domains (2) summary
      pfam09360
      Location:56 → 85
      zf-CDGSH; Iron-binding zinc finger CDGSH type
      cl02748
      Location:93 → 129
      zf-CDGSH; Iron-binding zinc finger CDGSH type

    2. NM_001364153.1 → NP_001351082.1  CDGSH iron-sulfur domain-containing protein 3, mitochondrial isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL596123, BC147739
      UniProtKB/TrEMBL
      B3DFI8
      Conserved Domains (1) summary
      pfam09360
      Location:136 → 165
      zf-CDGSH; Iron-binding zinc finger CDGSH type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      97576291..97579451
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533029.3 → XP_006533092.1  CDGSH iron-sulfur domain-containing protein 3, mitochondrial isoform X1

      UniProtKB/TrEMBL
      B3DFI8
      Conserved Domains (1) summary
      pfam09360
      Location:117 → 146
      zf-CDGSH; Iron-binding zinc finger CDGSH type
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B1AR13.1 GenPept UniProtKB/Swiss-Prot:B1AR13

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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