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    Tagln3 transgelin 3 [ Mus musculus (house mouse) ]

    Gene ID: 56370, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Tagln3provided by MGI
    Official Full Name
    transgelin 3provided by MGI
    Primary source
    MGI:MGI:1926784
    See related
    Ensembl:ENSMUSG00000022658 AllianceGenome:MGI:1926784
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Np25; 2700038H05Rik; 2900005O10Rik
    Summary
    Predicted to enable actin filament binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Is active in synapse. Is expressed in central nervous system; gut; olfactory epithelium; peripheral nervous system; and retina. Orthologous to human TAGLN3 (transgelin 3). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 204.8), CNS E14 (RPKM 149.6) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tagln3 in Genome Data Viewer
    Location:
    16 B5; 16 29.99 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (45531591..45545271, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (45711230..45724531, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene cDNA sequence, BC016579 Neighboring gene STARR-seq mESC enhancer starr_40918 Neighboring gene transmembrane serine protease 7 Neighboring gene STARR-seq mESC enhancer starr_40919 Neighboring gene STARR-seq mESC enhancer starr_40920 Neighboring gene STARR-seq mESC enhancer starr_40921 Neighboring gene abhydrolase domain containing 10 Neighboring gene pleckstrin homology like domain, family B, member 2 Neighboring gene STARR-seq mESC enhancer starr_40922 Neighboring gene predicted gene 15638

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Two quantitative trait loci for prepulse inhibition of startle identified on mouse chromosome 16 using chromosome substitution strains. Petryshen TL, et al. Genetics, 2005 Dec. PMID 15998716, Free PMC Article
    2. Action potential-coupled Rho GTPase signaling drives presynaptic plasticity. O'Neil SD, et al. Elife, 2021 Jul 16. PMID 34269176, Free PMC Article
    3. Regulation of downstream neuronal genes by proneural transcription factors during initial neurogenesis in the vertebrate brain. Ware M, et al. Neural Dev, 2016 Dec 7. PMID 27923395, Free PMC Article
    4. A proteomic comparison of immature and mature mouse gonadotrophs reveals novel differentially expressed nuclear proteins that regulate gonadotropin gene transcription and RNA splicing. Feng J, et al. Biol Reprod, 2008 Sep. PMID 18480465, Free PMC Article
    5. Expression profiling the developing mammalian enteric nervous system identifies marker and candidate Hirschsprung disease genes. Heanue TA, et al. Proc Natl Acad Sci U S A, 2006 May 2. PMID 16632597, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in myelin sheath HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transgelin-3
    Names
    neuronal protein Np25

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019754.3 → NP_062728.1  transgelin-3

      See identical proteins and their annotated locations for NP_062728.1

      Status: PROVISIONAL

      Source sequence(s)
      BC055338
      Consensus CDS
      CCDS28200.1
      UniProtKB/Swiss-Prot
      Q9R1Q8
      Related
      ENSMUSP00000093762.5, ENSMUST00000096057.5
      Conserved Domains (2) summary
      pfam00402
      Location:174 → 198
      Calponin; Calponin family repeat
      cd21281
      Location:23 → 141
      CH_TAGLN3; calponin homology (CH) domain found in transgelin-3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      45531591..45545271 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004939202.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R1Q8.1 GenPept UniProtKB/Swiss-Prot:Q9R1Q8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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