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    Arhgap27 Rho GTPase activating protein 27 [ Mus musculus (house mouse) ]

    Gene ID: 544817, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Arhgap27provided by MGI
    Official Full Name
    Rho GTPase activating protein 27provided by MGI
    Primary source
    MGI:MGI:1916903
    See related
    Ensembl:ENSMUSG00000034255 AllianceGenome:MGI:1916903
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sh3d20; Gm21552; 2310069I04Rik; 5730442P18Rik
    Summary
    Predicted to enable GTPase activator activity and SH3 domain binding activity. Predicted to be involved in Rho protein signal transduction and receptor-mediated endocytosis. Predicted to be located in endosome. Predicted to be active in cytoplasm and plasma membrane. Is expressed in brain; sensory organ; and skeleton. Orthologous to human ARHGAP27 (Rho GTPase activating protein 27). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in colon adult (RPKM 40.0), duodenum adult (RPKM 33.5) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Arhgap27 in Genome Data Viewer
    Location:
    11; 11 E1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (103222310..103254518, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (103331484..103363692, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 32 Neighboring gene predicted gene, 51920 Neighboring gene mitogen-activated protein kinase kinase kinase 14 Neighboring gene predicted gene, 34823 Neighboring gene STARR-positive B cell enhancer ABC_E10718 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:103128947-103129269 Neighboring gene STARR-seq mESC enhancer starr_30841 Neighboring gene STARR-seq mESC enhancer starr_30842 Neighboring gene STARR-positive B cell enhancer ABC_E3026 Neighboring gene Rho GTPase activating protein 27, opposite strand 3 Neighboring gene STARR-positive B cell enhancer ABC_E8459 Neighboring gene pleckstrin homology domain containing, family M (with RUN domain) member 1 Neighboring gene STARR-seq mESC enhancer starr_30848 Neighboring gene STARR-positive B cell enhancer ABC_E9376 Neighboring gene STARR-positive B cell enhancer ABC_E3027 Neighboring gene predicted gene, 39397

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships. Peck J, et al. FEBS Lett, 2002 Sep 25. PMID 12297274
    2. Structure and function analysis of the CMS/CIN85 protein family identifies actin-bundling properties and heterotypic-complex formation. Gaidos G, et al. J Cell Sci, 2007 Jul 15. PMID 17606992
    3. CD2AP regulates SUMOylation of CIN85 in podocytes. Tossidou I, et al. Mol Cell Biol, 2012 Mar. PMID 22203040, Free PMC Article
    4. Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. Pan J, et al. Am J Reprod Immunol, 2015 Sep. PMID 26073538
    5. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC62780, MGC169916, MGC169917

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables SH3 domain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in receptor-mediated endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in small GTPase-mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein 27
    Names
    CIN85-associated multi-domain-containing Rho GTPase-activating protein 1
    SH3 domain containing 20
    rho-type GTPase-activating protein 27

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205236.1 → NP_001192165.1  rho GTPase-activating protein 27 isoform 1

      See identical proteins and their annotated locations for NP_001192165.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL662804, AL772325
      Consensus CDS
      CCDS56815.1
      UniProtKB/Swiss-Prot
      A2AB59, Q3V366, Q4V9V5
      Related
      ENSMUSP00000102639.2, ENSMUST00000107024.9
      Conserved Domains (6) summary
      cd12069
      Location:10 → 66
      SH3_ARHGAP27; Src Homology 3 domain of Rho GTPase-activating protein 27
      COG5104
      Location:241 → 328
      PRP40; Splicing factor [RNA processing and modification]
      PRK12323
      Location:68 → 249
      PRK12323; DNA polymerase III subunit gamma/tau
      cd04403
      Location:675 → 861
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:480 → 594
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00397
      Location:248 → 278
      WW; WW domain

    2. NM_133715.5 → NP_598476.2  rho GTPase-activating protein 27 isoform 2

      See identical proteins and their annotated locations for NP_598476.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, and uses an alternate internal promoter, compared to variant 1. The encoded isoform (2) has a distinct and shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK046763, AL662804, BY552449
      Consensus CDS
      CCDS25517.1
      UniProtKB/Swiss-Prot
      A2AB59
      Related
      ENSMUSP00000039427.8, ENSMUST00000041385.14
      Conserved Domains (4) summary
      cd04403
      Location:476 → 662
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:281 → 395
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:281 → 394
      PH; PH domain
      pfam00397
      Location:49 → 79
      WW; WW domain

    3. NM_183288.3 → NP_899111.2  rho GTPase-activating protein 27 isoform 3

      See identical proteins and their annotated locations for NP_899111.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks several 3' exons and contains an alternate 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is significantly shorter than isoform 1.
      Source sequence(s)
      AL772325, CJ068176
      Consensus CDS
      CCDS36350.1
      UniProtKB/TrEMBL
      A2AKN5, B2RR95
      Related
      ENSMUSP00000102637.3, ENSMUST00000092557.6
      Conserved Domains (1) summary
      cd12069
      Location:10 → 66
      SH3_ARHGAP27; Src Homology 3 domain of Rho GTPase-activating protein 27

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      103222310..103254518 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156858.1 → XP_036012751.1  rho GTPase-activating protein 27 isoform X3

      Conserved Domains (6) summary
      cd12069
      Location:10 → 66
      SH3_ARHGAP27; Src Homology 3 domain of Rho GTPase-activating protein 27
      COG5104
      Location:241 → 328
      PRP40; Splicing factor [RNA processing and modification]
      PRK12323
      Location:68 → 249
      PRK12323; DNA polymerase III subunit gamma/tau
      cd04403
      Location:620 → 806
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:425 → 539
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00397
      Location:248 → 278
      WW; WW domain

    2. XM_036156857.1 → XP_036012750.1  rho GTPase-activating protein 27 isoform X2

      Conserved Domains (6) summary
      cd12069
      Location:10 → 66
      SH3_ARHGAP27; Src Homology 3 domain of Rho GTPase-activating protein 27
      COG5104
      Location:241 → 328
      PRP40; Splicing factor [RNA processing and modification]
      PRK12323
      Location:68 → 249
      PRK12323; DNA polymerase III subunit gamma/tau
      cd04403
      Location:647 → 833
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:452 → 566
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00397
      Location:248 → 278
      WW; WW domain

    3. XM_036156856.1 → XP_036012749.1  rho GTPase-activating protein 27 isoform X1

      UniProtKB/Swiss-Prot
      A2AB59, Q3V366, Q4V9V5
      Conserved Domains (6) summary
      cd12069
      Location:10 → 66
      SH3_ARHGAP27; Src Homology 3 domain of Rho GTPase-activating protein 27
      COG5104
      Location:241 → 328
      PRP40; Splicing factor [RNA processing and modification]
      PRK12323
      Location:68 → 249
      PRK12323; DNA polymerase III subunit gamma/tau
      cd04403
      Location:675 → 861
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:480 → 594
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00397
      Location:248 → 278
      WW; WW domain

    4. XM_006533754.5 → XP_006533817.1  rho GTPase-activating protein 27 isoform X4

      Conserved Domains (4) summary
      COG5104
      Location:56 → 143
      PRP40; Splicing factor [RNA processing and modification]
      cd04403
      Location:490 → 676
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:295 → 409
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00397
      Location:63 → 93
      WW; WW domain

    RNA

    1. XR_001780030.3 RNA Sequence

      Related
      ENSMUST00000116102.9
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AB59.1 GenPept UniProtKB/Swiss-Prot:A2AB59

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