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    Glb1l3 galactosidase, beta 1 like 3 [ Mus musculus (house mouse) ]

    Gene ID: 70893, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Glb1l3provided by MGI
    Official Full Name
    galactosidase, beta 1 like 3provided by MGI
    Primary source
    MGI:MGI:1918143
    See related
    Ensembl:ENSMUSG00000031966 AllianceGenome:MGI:1918143
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4921509F24Rik
    Summary
    Predicted to enable beta-galactosidase activity. Predicted to be involved in galactose catabolic process. Predicted to be active in vacuole. Orthologous to human GLB1L3 (galactosidase beta 1 like 3). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in genital fat pad adult (RPKM 18.9) and testis adult (RPKM 12.3) See more
    Orthologs
    human all
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    Genomic context

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    See Glb1l3 in Genome Data Viewer
    Location:
    9 A4; 9 11.67 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (26729249..26773394, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (26817953..26862099, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene beta-1,3-glucuronyltransferase 1 Neighboring gene galactosidase, beta 1-like 2 Neighboring gene STARR-seq mESC enhancer starr_23614 Neighboring gene predicted gene 1110 Neighboring gene STARR-seq mESC enhancer starr_23615 Neighboring gene STARR-seq mESC enhancer starr_23616 Neighboring gene zinc finger CCCH type containing 11A pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Altered expression of β-galactosidase-1-like protein 3 (Glb1l3) in the retinal pigment epithelium (RPE)-specific 65-kDa protein knock-out mouse model of Leber's congenital amaurosis. Le Carré J, et al. Mol Vis, 2011. PMID 21633714, Free PMC Article
    2. The human (PEDB) and mouse (mPEDB) Prostate Expression Databases. Nelson PS, et al. Nucleic Acids Res, 2002 Jan 1. PMID 11752298, Free PMC Article
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Early-onset downregulation of Glb1l3 in Rpe65-related disease. Impaired expression of Glb1l3 is mostly due to absence of chromophore 11-cis retinal.
      Title: Altered expression of β-galactosidase-1-like protein 3 (Glb1l3) in the retinal pigment epithelium (RPE)-specific 65-kDa protein knock-out mouse model of Leber's congenital amaurosis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables beta-galactosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-galactosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in galactose catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    beta-galactosidase-1-like protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113323.1 → NP_001106794.1  beta-galactosidase-1-like protein 3 precursor

      See identical proteins and their annotated locations for NP_001106794.1

      Status: VALIDATED

      Source sequence(s)
      AC109831, BB281918, BC132200, BY363615, DV051729
      Consensus CDS
      CCDS85650.1
      UniProtKB/Swiss-Prot
      A2RSQ1, Q9D5X3
      UniProtKB/TrEMBL
      A0A1B0GSK9
      Related
      ENSMUSP00000147979.2, ENSMUST00000210274.2
      Conserved Domains (1) summary
      pfam01301
      Location:69 → 379
      Glyco_hydro_35; Glycosyl hydrolases family 35

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      26729249..26773394 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510593.5 → XP_006510656.1  beta-galactosidase-1-like protein 3 isoform X2

      See identical proteins and their annotated locations for XP_006510656.1

      UniProtKB/Swiss-Prot
      A2RSQ1, Q9D5X3
      UniProtKB/TrEMBL
      A0A1B0GSK9
      Conserved Domains (1) summary
      pfam01301
      Location:69 → 379
      Glyco_hydro_35; Glycosyl hydrolases family 35

    2. XM_006510595.3 → XP_006510658.1  beta-galactosidase-1-like protein 3 isoform X5

      Conserved Domains (2) summary
      PRK10531
      Location:255 → 286
      PRK10531; putative acyl-CoA thioester hydrolase
      cl38930
      Location:1 → 53
      AmyAc_family; Alpha amylase catalytic domain family

    3. XM_006510591.5 → XP_006510654.1  beta-galactosidase-1-like protein 3 isoform X1

      UniProtKB/Swiss-Prot
      A2RSQ1, Q9D5X3
      Conserved Domains (1) summary
      pfam01301
      Location:69 → 379
      Glyco_hydro_35; Glycosyl hydrolases family 35

    4. XM_017313588.3 → XP_017169077.1  beta-galactosidase-1-like protein 3 isoform X3

      Conserved Domains (2) summary
      PRK10531
      Location:316 → 347
      PRK10531; putative acyl-CoA thioester hydrolase
      cl38930
      Location:17 → 113
      AmyAc_family; Alpha amylase catalytic domain family

    5. XM_006510594.5 → XP_006510657.1  beta-galactosidase-1-like protein 3 isoform X4

      Conserved Domains (2) summary
      PRK10531
      Location:256 → 287
      PRK10531; putative acyl-CoA thioester hydrolase
      cl38930
      Location:1 → 53
      AmyAc_family; Alpha amylase catalytic domain family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2RSQ1.1 GenPept UniProtKB/Swiss-Prot:A2RSQ1

    Gene LinkOut

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