Pgp phosphoglycolate phosphatase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pgpprovided by MGI
Official Full Name: phosphoglycolate phosphataseprovided by MGI
Primary source: MGI:MGI:1914328
See related: Ensembl:ENSMUSG00000043445 AllianceGenome:MGI:1914328
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AUM; G3PP; 1700012G19Rik
Summary: Enables ADP phosphatase activity; magnesium ion binding activity; and phosphatase activity. Involved in glycerol biosynthetic process and glycerophospholipid metabolic process. Predicted to be active in cytoplasm. Is expressed in allantois; amnion; chorion; embryo; and yolk sac. Orthologous to human PGP (phosphoglycolate phosphatase). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Broad expression in testis adult (RPKM 702.9), adrenal adult (RPKM 264.5) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 12.39 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (24689400..24692084)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (24470426..24473110)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Functional Evaluation of P-gp and Bcrp at the Murine Blood-Cerebrospinal Fluid Barrier.
Title: Functional Evaluation of P-gp and Bcrp at the Murine Blood-Cerebrospinal Fluid Barrier.
Knockin replacement of Pgp with its phosphatase-inactive Pgp(D34N) mutant is embryonically lethal due to intrauterine growth arrest and developmental delay in midgestation. PGP inactivation attenuated triosephosphate isomerase activity, increased triglyceride levels at the expense of the cellular phosphatidylcholine content, and inhibited cell proliferation.
Title: An essential developmental function for murine phosphoglycolate phosphatase in safeguarding cell proliferation.
our findings establish that PGP, an aspartate-dependent HAD phosphatase, is transiently inactivated by reversible oxidation in cells
Title: Reversible oxidation controls the activity and oligomeric state of the mammalian phosphoglycolate phosphatase AUM.
A previously known phosphoglycolate phosphatase (PGP) with an uncertain function acts as a specific glycerol-3-phosphate phosphatase and plays a role in the glucose and lipid metabolism and signaling, and the response to metabolic stress.
Title: Identification of a mammalian glycerol-3-phosphate phosphatase: Role in metabolism and signaling in pancreatic β-cells and hepatocytes.
Evolutionary and structural analyses of mammalian haloacid dehalogenase-type phosphatases AUM and chronophin provide insight into the basis of their different substrate specificities.
Title: Evolutionary and structural analyses of mammalian haloacid dehalogenase-type phosphatases AUM and chronophin provide insight into the basis of their different substrate specificities.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (2) 1 citation

General gene information

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Markers

RH98228 (e-PCR)
- UniSTS:91450

RH127723 (e-PCR)
- UniSTS:211033

AI481330 (e-PCR)
- UniSTS:160626

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ADP phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables glycerol-1-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables glycerol-3-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycerol-3-phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables glycerol-3-phosphatase activity	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphoglycolate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoglycolate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in glycerol biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycerol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in glycerophospholipid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycerophospholipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gluconeogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glycerol-3-phosphate phosphatase

Names: PGPase; aspartate-based ubiquitous Mg(2+)-dependent phosphatase

NP_080230.2

EC 3.1.3.21

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025954.4 → NP_080230.2 glycerol-3-phosphate phosphatase

See identical proteins and their annotated locations for NP_080230.2

Status: VALIDATED

Source sequence(s)

AC154237

Consensus CDS

CCDS28482.1

UniProtKB/Swiss-Prot

Q8CHP8

Related

ENSMUSP00000052866.7, ENSMUST00000053024.8

Conserved Domains (1) summary

cd07510
Location:28 → 319

HAD_Pase_UmpH-like; UmpH/NagD family phosphatase, similar to human PGP phosphoglycolate phosphatase and Schizosaccharomyces pombe PHO2 p-nitrophenylphosphatase