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    Huwe1 HECT, UBA and WWE domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 59026, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Huwe1provided by MGI
    Official Full Name
    HECT, UBA and WWE domain containing 1provided by MGI
    Primary source
    MGI:MGI:1926884
    See related
    Ensembl:ENSMUSG00000025261 AllianceGenome:MGI:1926884
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mule; Ib772; LASU1; Ureb1; Gm1718; Arf-bp1; 5430439H10Rik; C430014N20Rik
    Summary
    Predicted to enable DNA binding activity and histone ubiquitin ligase activity. Involved in circadian regulation of gene expression and positive regulation of protein ubiquitination. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in Golgi membrane and nucleus. Is expressed in several structures, including extraembryonic component. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Turner type. Orthologous to human HUWE1 (HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 24.1), CNS E14 (RPKM 22.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Huwe1 in Genome Data Viewer
    Location:
    X F3; X 68.46 cM
    Exon count:
    89
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (150583779..150718413)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (151800785..151935417)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_48087 Neighboring gene nuclear encoded rRNA 5S 13 Neighboring gene STARR-positive B cell enhancer ABC_E2539 Neighboring gene tubulin tyrosine ligase-like 1 pseudogene Neighboring gene microRNA 3113 Neighboring gene STARR-seq mESC enhancer starr_48088 Neighboring gene microRNA let7f-2 Neighboring gene microRNA 98 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene hydroxysteroid (17-beta) dehydrogenase 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Dichotomous role of pancreatic HUWE1/MULE/ARF-BP1 in modulating beta cell apoptosis in mice under physiological and genotoxic conditions. Wang L, et al. Diabetologia, 2014 Sep. PMID 24981769
    2. Huwe1 Regulates the Establishment and Maintenance of Spermatogonia by Suppressing DNA Damage Response. Fok KL, et al. Endocrinology, 2017 Nov 1. PMID 28938460
    3. Ubiquitin Ligase Huwe1 Modulates Spermatogenesis by Regulating Spermatogonial Differentiation and Entry into Meiosis. Bose R, et al. Sci Rep, 2017 Dec 19. PMID 29259204, Free PMC Article
    4. Huwe1 ubiquitin ligase is essential to synchronize neuronal and glial differentiation in the developing cerebellum. D'Arca D, et al. Proc Natl Acad Sci U S A, 2010 Mar 30. PMID 20231446, Free PMC Article
    5. Ubiquitin ligase E3 HUWE1/MULE targets transferrin receptor for degradation and suppresses ferroptosis in acute liver injury. Wu Y, et al. Cell Death Differ, 2022 Sep. PMID 35260822, Free PMC Article

    See all (92) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tight regulation of a nuclear HAPSTR1-HUWE1 pathway essential for mammalian life.
      Title: Tight regulation of a nuclear HAPSTR1-HUWE1 pathway essential for mammalian life.
    2. Ubiquitin ligase E3 HUWE1/MULE targets transferrin receptor for degradation and suppresses ferroptosis in acute liver injury.
      Title: Ubiquitin ligase E3 HUWE1/MULE targets transferrin receptor for degradation and suppresses ferroptosis in acute liver injury.
    3. [Ubiquitin-conjugating enzyme UBE2Q2 participates in HUWE1-mediated protection on renal tubulointerstitial fibrosis].
      Title: [Ubiquitin-conjugating enzyme UBE2Q2 participates in HUWE1-mediated protection on renal tubulointerstitial fibrosis].
    4. BRPF3-HUWE1-mediated regulation of MYST2 is required for differentiation and cell-cycle progression in embryonic stem cells.
      Title: BRPF3-HUWE1-mediated regulation of MYST2 is required for differentiation and cell-cycle progression in embryonic stem cells.
    5. HUWE1 mediates inflammasome activation and promotes host defense against bacterial infection.
      Title: HUWE1 mediates inflammasome activation and promotes host defense against bacterial infection.
    6. The functions of Huwe1 in spermatogenesis.
      Title: Ubiquitin Ligase Huwe1 Modulates Spermatogenesis by Regulating Spermatogonial Differentiation and Entry into Meiosis.
    7. Mule-mediated ubiquitination of the novel substrate KLF4 regulates T-cell proliferation, autoimmunity and antiviral immune responses.
      Title: K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression.
    8. The data supports an indispensable role for Mule in cardiac homeostasis through the regulation of mitochondrial function via maintenance of Pgc-1alpha and Pink1 expression and persistent negative regulation of c-Myc.
      Title: The E3 ligase Mule protects the heart against oxidative stress and mitochondrial dysfunction through Myc-dependent inactivation of Pgc-1α and Pink1.
    9. these results suggest that HUWE1 protein could contribute to preimplantation embryo development and dysregulated expression of HUWE1 could be related to poor embryo development and miscarriage in IVF clinic.
      Title: HUWE1 plays important role in mouse preimplantation embryo development and the dysregulation is associated with poor embryo development in humans.
    10. Mule interacts directly with beta-catenin and targets it for degradation under conditions of hyperactive Wnt signaling, suggesting that Mule uses various mechanisms to fine-tune the Wnt pathway and provides multiple safeguards against tumorigenesis.
      Title: E3 ubiquitin ligase Mule targets β-catenin under conditions of hyperactive Wnt signaling.
    Submit: New GeneRIF Correction See all GeneRIFs (30)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (3) 
    • Targeted (4)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone ubiquitin ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone ubiquitin ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in base-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in base-excision repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in base-excision repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in circadian regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in circadian regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in membrane fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of mitochondrial fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of type 2 mitophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein monoubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase HUWE1
    Names
    E3Histone
    HECT, UBA and WWE domain-containing protein 1
    HECT-type E3 ubiquitin transferase HUWE1
    Mcl-1 ubiquitin ligase
    URE-B1
    URE-binding protein 1
    upstream regulatory element binding protein 1
    NP_067498.4
    XP_006528996.1
    XP_006528997.1
    XP_006528999.1
    XP_006529000.1
    XP_006529001.1
    XP_006529002.1
    XP_006529003.1
    XP_006529006.1
    XP_006529011.1
    XP_006529012.1
    XP_006529014.1
    XP_011246154.1
    XP_030107294.1
    XP_030107295.1
    XP_030107296.1
    XP_030107297.1
    XP_030107298.1
    XP_030107299.1
    XP_030107300.1
    XP_030107302.1
    XP_030107304.1
    XP_030107306.1
    XP_030107307.1
    XP_030107308.1
    XP_030107309.1
    XP_030107310.1
    XP_030107311.1
    XP_030107312.1
    XP_030107314.1
    XP_030107315.1
    XP_030107316.1
    XP_030107317.1
    XP_030107318.1
    XP_036017951.1
    XP_036017952.1
    XP_036017953.1
    XP_036017954.1
    XP_036017955.1
    XP_036017956.1
    XP_036017957.1
    XP_036017958.1
    XP_036017959.1
    XP_036017960.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021523.5 → NP_067498.4  E3 ubiquitin-protein ligase HUWE1

      See identical proteins and their annotated locations for NP_067498.4

      Status: VALIDATED

      Source sequence(s)
      AL672180, AL954855, BX571795
      Consensus CDS
      CCDS41176.1
      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      UniProtKB/TrEMBL
      A2AFQ0
      Related
      ENSMUSP00000026292.9, ENSMUST00000026292.15
      Conserved Domains (7) summary
      cd00078
      Location:4023 → 4376
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1317 → 1356
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1617 → 1678
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:431 → 814
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3011 → 3042
      DUF4414; Domain of unknown function (DUF4414)
      NF033913
      Location:2731 → 2914
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      150583779..150718413
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162059.1 → XP_036017952.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      Conserved Domains (7) summary
      cd00078
      Location:4101 → 4454
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1395 → 1434
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1695 → 1756
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:431 → 892
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3089 → 3120
      DUF4414; Domain of unknown function (DUF4414)
      NF033913
      Location:2809 → 2992
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    2. XM_030251448.1 → XP_030107308.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      Conserved Domains (7) summary
      cd00078
      Location:4027 → 4380
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1321 → 1360
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1621 → 1682
      WWE; WWE domain
      pfam06012
      Location:18 → 293
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:357 → 818
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3015 → 3046
      DUF4414; Domain of unknown function (DUF4414)
      NF033913
      Location:2735 → 2918
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    3. XM_030251434.1 → XP_030107294.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      Conserved Domains (7) summary
      cd00078
      Location:4101 → 4454
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1395 → 1434
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1695 → 1756
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:431 → 892
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3089 → 3120
      DUF4414; Domain of unknown function (DUF4414)
      NF033913
      Location:2809 → 2992
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    4. XM_030251447.1 → XP_030107307.1  E3 ubiquitin-protein ligase HUWE1 isoform X4

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      Conserved Domains (6) summary
      cd00078
      Location:4086 → 4439
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1395 → 1434
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1695 → 1756
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:430 → 892
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3089 → 3122
      DUF4414; Domain of unknown function (DUF4414)

    5. XM_036162060.1 → XP_036017953.1  E3 ubiquitin-protein ligase HUWE1 isoform X5

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      Conserved Domains (7) summary
      cd00078
      Location:4068 → 4421
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1395 → 1434
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1695 → 1756
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:431 → 892
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3056 → 3087
      DUF4414; Domain of unknown function (DUF4414)
      NF033913
      Location:2776 → 2959
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    6. XM_030251458.1 → XP_030107318.1  E3 ubiquitin-protein ligase HUWE1 isoform X9

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      Conserved Domains (6) summary
      cd00078
      Location:3967 → 4320
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1395 → 1434
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1695 → 1756
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:430 → 892
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:2955 → 2988
      DUF4414; Domain of unknown function (DUF4414)

    7. XM_030251444.1 → XP_030107304.1  E3 ubiquitin-protein ligase HUWE1 isoform X2

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      Conserved Domains (6) summary
      cd00078
      Location:4099 → 4452
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1395 → 1434
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1695 → 1756
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:430 → 892
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3087 → 3120
      DUF4414; Domain of unknown function (DUF4414)

    8. XM_030251446.1 → XP_030107306.1  E3 ubiquitin-protein ligase HUWE1 isoform X3

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      Conserved Domains (6) summary
      cd00078
      Location:4092 → 4445
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1386 → 1425
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1686 → 1747
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:430 → 892
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3080 → 3113
      DUF4414; Domain of unknown function (DUF4414)

    9. XM_030251457.1 → XP_030107317.1  E3 ubiquitin-protein ligase HUWE1 isoform X8

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      Conserved Domains (7) summary
      cd00078
      Location:4014 → 4367
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1308 → 1347
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1608 → 1669
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:431 → 814
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3002 → 3033
      DUF4414; Domain of unknown function (DUF4414)
      NF033913
      Location:2722 → 2905
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    10. XM_030251435.1 → XP_030107295.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      Conserved Domains (7) summary
      cd00078
      Location:4101 → 4454
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1395 → 1434
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1695 → 1756
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:431 → 892
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3089 → 3120
      DUF4414; Domain of unknown function (DUF4414)
      NF033913
      Location:2809 → 2992
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    11. XM_006528934.3 → XP_006528997.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      See identical proteins and their annotated locations for XP_006528997.1

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      Conserved Domains (7) summary
      cd00078
      Location:4101 → 4454
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1395 → 1434
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1695 → 1756
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:431 → 892
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3089 → 3120
      DUF4414; Domain of unknown function (DUF4414)
      NF033913
      Location:2809 → 2992
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    12. XM_036162063.1 → XP_036017956.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      Conserved Domains (7) summary
      cd00078
      Location:4027 → 4380
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1321 → 1360
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1621 → 1682
      WWE; WWE domain
      pfam06012
      Location:18 → 293
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:357 → 818
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3015 → 3046
      DUF4414; Domain of unknown function (DUF4414)
      NF033913
      Location:2735 → 2918
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    13. XM_006528938.3 → XP_006529001.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      See identical proteins and their annotated locations for XP_006529001.1

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      Conserved Domains (7) summary
      cd00078
      Location:4101 → 4454
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1395 → 1434
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1695 → 1756
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:431 → 892
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3089 → 3120
      DUF4414; Domain of unknown function (DUF4414)
      NF033913
      Location:2809 → 2992
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    14. XM_030251449.1 → XP_030107309.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      Conserved Domains (7) summary
      cd00078
      Location:4027 → 4380
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1321 → 1360
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1621 → 1682
      WWE; WWE domain
      pfam06012
      Location:18 → 293
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:357 → 818
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3015 → 3046
      DUF4414; Domain of unknown function (DUF4414)
      NF033913
      Location:2735 → 2918
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    15. XM_006528939.3 → XP_006529002.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      See identical proteins and their annotated locations for XP_006529002.1

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      Conserved Domains (7) summary
      cd00078
      Location:4101 → 4454
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1395 → 1434
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1695 → 1756
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:431 → 892
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3089 → 3120
      DUF4414; Domain of unknown function (DUF4414)
      NF033913
      Location:2809 → 2992
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    16. XM_006528936.3 → XP_006528999.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      See identical proteins and their annotated locations for XP_006528999.1

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      Conserved Domains (7) summary
      cd00078
      Location:4101 → 4454
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1395 → 1434
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1695 → 1756
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:431 → 892
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3089 → 3120
      DUF4414; Domain of unknown function (DUF4414)
      NF033913
      Location:2809 → 2992
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    17. XM_036162061.1 → XP_036017954.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      Conserved Domains (7) summary
      cd00078
      Location:4027 → 4380
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1321 → 1360
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1621 → 1682
      WWE; WWE domain
      pfam06012
      Location:18 → 293
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:357 → 818
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3015 → 3046
      DUF4414; Domain of unknown function (DUF4414)
      NF033913
      Location:2735 → 2918
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    18. XM_030251436.1 → XP_030107296.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      Conserved Domains (7) summary
      cd00078
      Location:4101 → 4454
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1395 → 1434
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1695 → 1756
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:431 → 892
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3089 → 3120
      DUF4414; Domain of unknown function (DUF4414)
      NF033913
      Location:2809 → 2992
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    19. XM_036162062.1 → XP_036017955.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      Conserved Domains (7) summary
      cd00078
      Location:4027 → 4380
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1321 → 1360
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1621 → 1682
      WWE; WWE domain
      pfam06012
      Location:18 → 293
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:357 → 818
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3015 → 3046
      DUF4414; Domain of unknown function (DUF4414)
      NF033913
      Location:2735 → 2918
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    20. XM_006528937.3 → XP_006529000.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      See identical proteins and their annotated locations for XP_006529000.1

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      Conserved Domains (7) summary
      cd00078
      Location:4101 → 4454
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1395 → 1434
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1695 → 1756
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:431 → 892
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3089 → 3120
      DUF4414; Domain of unknown function (DUF4414)
      NF033913
      Location:2809 → 2992
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    21. XM_030251455.1 → XP_030107315.1  E3 ubiquitin-protein ligase HUWE1 isoform X7

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      UniProtKB/TrEMBL
      A2AFQ0
      Conserved Domains (7) summary
      cd00078
      Location:4023 → 4376
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1317 → 1356
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1617 → 1678
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:431 → 814
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3011 → 3042
      DUF4414; Domain of unknown function (DUF4414)
      NF033913
      Location:2731 → 2914
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    22. XM_036162064.1 → XP_036017957.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      Conserved Domains (7) summary
      cd00078
      Location:4027 → 4380
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1321 → 1360
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1621 → 1682
      WWE; WWE domain
      pfam06012
      Location:18 → 293
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:357 → 818
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3015 → 3046
      DUF4414; Domain of unknown function (DUF4414)
      NF033913
      Location:2735 → 2918
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    23. XM_006528940.3 → XP_006529003.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      See identical proteins and their annotated locations for XP_006529003.1

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      Conserved Domains (7) summary
      cd00078
      Location:4101 → 4454
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1395 → 1434
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1695 → 1756
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:431 → 892
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3089 → 3120
      DUF4414; Domain of unknown function (DUF4414)
      NF033913
      Location:2809 → 2992
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    24. XM_036162066.1 → XP_036017959.1  E3 ubiquitin-protein ligase HUWE1 isoform X7

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      UniProtKB/TrEMBL
      A2AFQ0
      Conserved Domains (7) summary
      cd00078
      Location:4023 → 4376
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1317 → 1356
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1617 → 1678
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:431 → 814
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3011 → 3042
      DUF4414; Domain of unknown function (DUF4414)
      NF033913
      Location:2731 → 2914
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    25. XM_006528948.3 → XP_006529011.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      Conserved Domains (7) summary
      cd00078
      Location:4027 → 4380
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1321 → 1360
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1621 → 1682
      WWE; WWE domain
      pfam06012
      Location:18 → 293
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:357 → 818
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3015 → 3046
      DUF4414; Domain of unknown function (DUF4414)
      NF033913
      Location:2735 → 2918
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    26. XM_006528951.3 → XP_006529014.1  E3 ubiquitin-protein ligase HUWE1 isoform X10

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      Conserved Domains (6) summary
      cd00078
      Location:3949 → 4302
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1243 → 1282
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1543 → 1604
      WWE; WWE domain
      pfam06012
      Location:18 → 293
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:356 → 740
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:2937 → 2970
      DUF4414; Domain of unknown function (DUF4414)

    27. XM_006528933.3 → XP_006528996.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      See identical proteins and their annotated locations for XP_006528996.1

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      Conserved Domains (7) summary
      cd00078
      Location:4101 → 4454
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1395 → 1434
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1695 → 1756
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:431 → 892
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3089 → 3120
      DUF4414; Domain of unknown function (DUF4414)
      NF033913
      Location:2809 → 2992
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    28. XM_006528949.4 → XP_006529012.1  E3 ubiquitin-protein ligase HUWE1 isoform X7

      See identical proteins and their annotated locations for XP_006529012.1

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      UniProtKB/TrEMBL
      A2AFQ0
      Conserved Domains (7) summary
      cd00078
      Location:4023 → 4376
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1317 → 1356
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1617 → 1678
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:431 → 814
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3011 → 3042
      DUF4414; Domain of unknown function (DUF4414)
      NF033913
      Location:2731 → 2914
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    29. XM_030251450.1 → XP_030107310.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      Conserved Domains (7) summary
      cd00078
      Location:4027 → 4380
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1321 → 1360
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1621 → 1682
      WWE; WWE domain
      pfam06012
      Location:18 → 293
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:357 → 818
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3015 → 3046
      DUF4414; Domain of unknown function (DUF4414)
      NF033913
      Location:2735 → 2918
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    30. XM_011247852.2 → XP_011246154.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      See identical proteins and their annotated locations for XP_011246154.1

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      Conserved Domains (7) summary
      cd00078
      Location:4101 → 4454
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1395 → 1434
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1695 → 1756
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:431 → 892
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3089 → 3120
      DUF4414; Domain of unknown function (DUF4414)
      NF033913
      Location:2809 → 2992
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    31. XM_030251451.1 → XP_030107311.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      Conserved Domains (7) summary
      cd00078
      Location:4027 → 4380
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1321 → 1360
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1621 → 1682
      WWE; WWE domain
      pfam06012
      Location:18 → 293
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:357 → 818
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3015 → 3046
      DUF4414; Domain of unknown function (DUF4414)
      NF033913
      Location:2735 → 2918
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    32. XM_030251437.1 → XP_030107297.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      Conserved Domains (7) summary
      cd00078
      Location:4101 → 4454
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1395 → 1434
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1695 → 1756
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:431 → 892
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3089 → 3120
      DUF4414; Domain of unknown function (DUF4414)
      NF033913
      Location:2809 → 2992
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    33. XM_030251452.1 → XP_030107312.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      Conserved Domains (7) summary
      cd00078
      Location:4027 → 4380
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1321 → 1360
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1621 → 1682
      WWE; WWE domain
      pfam06012
      Location:18 → 293
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:357 → 818
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3015 → 3046
      DUF4414; Domain of unknown function (DUF4414)
      NF033913
      Location:2735 → 2918
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    34. XM_006528943.3 → XP_006529006.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      See identical proteins and their annotated locations for XP_006529006.1

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      Conserved Domains (7) summary
      cd00078
      Location:4101 → 4454
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1395 → 1434
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1695 → 1756
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:431 → 892
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3089 → 3120
      DUF4414; Domain of unknown function (DUF4414)
      NF033913
      Location:2809 → 2992
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    35. XM_030251456.1 → XP_030107316.1  E3 ubiquitin-protein ligase HUWE1 isoform X7

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      UniProtKB/TrEMBL
      A2AFQ0
      Conserved Domains (7) summary
      cd00078
      Location:4023 → 4376
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1317 → 1356
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1617 → 1678
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:431 → 814
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3011 → 3042
      DUF4414; Domain of unknown function (DUF4414)
      NF033913
      Location:2731 → 2914
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    36. XM_036162067.1 → XP_036017960.1  E3 ubiquitin-protein ligase HUWE1 isoform X8

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      Conserved Domains (7) summary
      cd00078
      Location:4014 → 4367
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1308 → 1347
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1608 → 1669
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:431 → 814
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3002 → 3033
      DUF4414; Domain of unknown function (DUF4414)
      NF033913
      Location:2722 → 2905
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    37. XM_030251454.1 → XP_030107314.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      Conserved Domains (7) summary
      cd00078
      Location:4027 → 4380
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1321 → 1360
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1621 → 1682
      WWE; WWE domain
      pfam06012
      Location:18 → 293
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:357 → 818
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3015 → 3046
      DUF4414; Domain of unknown function (DUF4414)
      NF033913
      Location:2735 → 2918
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    38. XM_030251442.2 → XP_030107302.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      Conserved Domains (7) summary
      cd00078
      Location:4101 → 4454
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1395 → 1434
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1695 → 1756
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:431 → 892
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3089 → 3120
      DUF4414; Domain of unknown function (DUF4414)
      NF033913
      Location:2809 → 2992
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    39. XM_030251439.1 → XP_030107299.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      Conserved Domains (7) summary
      cd00078
      Location:4101 → 4454
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1395 → 1434
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1695 → 1756
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:431 → 892
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3089 → 3120
      DUF4414; Domain of unknown function (DUF4414)
      NF033913
      Location:2809 → 2992
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    40. XM_036162065.1 → XP_036017958.1  E3 ubiquitin-protein ligase HUWE1 isoform X6

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      Conserved Domains (7) summary
      cd00078
      Location:4027 → 4380
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1321 → 1360
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1621 → 1682
      WWE; WWE domain
      pfam06012
      Location:18 → 293
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:357 → 818
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3015 → 3046
      DUF4414; Domain of unknown function (DUF4414)
      NF033913
      Location:2735 → 2918
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    41. XM_030251438.1 → XP_030107298.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      Conserved Domains (7) summary
      cd00078
      Location:4101 → 4454
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1395 → 1434
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1695 → 1756
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:431 → 892
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3089 → 3120
      DUF4414; Domain of unknown function (DUF4414)
      NF033913
      Location:2809 → 2992
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    42. XM_030251440.1 → XP_030107300.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      Conserved Domains (7) summary
      cd00078
      Location:4101 → 4454
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1395 → 1434
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1695 → 1756
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:431 → 892
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3089 → 3120
      DUF4414; Domain of unknown function (DUF4414)
      NF033913
      Location:2809 → 2992
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    43. XM_036162058.1 → XP_036017951.1  E3 ubiquitin-protein ligase HUWE1 isoform X1

      UniProtKB/Swiss-Prot
      A2AFQ1, Q4G2Z1, Q5BMM7, Q6NS61, Q7TMY8, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2
      Conserved Domains (7) summary
      cd00078
      Location:4101 → 4454
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14288
      Location:1395 → 1434
      UBA_HUWE1; UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins
      pfam02825
      Location:1695 → 1756
      WWE; WWE domain
      pfam06012
      Location:92 → 367
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:431 → 892
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:3089 → 3120
      DUF4414; Domain of unknown function (DUF4414)
      NF033913
      Location:2809 → 2992
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TMY8.5 GenPept UniProtKB/Swiss-Prot:Q7TMY8

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