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    Smim45 small integral membrane protein 45 [ Mus musculus (house mouse) ]

    Gene ID: 76505, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Smim45provided by MGI
    Official Full Name
    small integral membrane protein 45provided by MGI
    Primary source
    MGI:MGI:1923755
    See related
    Ensembl:ENSMUSG00000068099 AllianceGenome:MGI:1923755
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1500009C09Rik
    Summary
    Predicted to be involved in neuron maturation. Predicted to be located in cytoplasm and nucleus. Is expressed in cerebral cortex. Orthologous to human SMIM45 (small integral membrane protein 45). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 39.0), frontal lobe adult (RPKM 31.9) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Smim45 in Genome Data Viewer
    Location:
    15 E1; 15 38.56 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (82136673..82144947)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (82252472..82260746)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene tumor necrosis factor receptor superfamily, member 13c Neighboring gene centromere protein M Neighboring gene STARR-positive B cell enhancer ABC_E8601 Neighboring gene STARR-seq mESC enhancer starr_39290 Neighboring gene predicted gene, 52180 Neighboring gene septin 3 Neighboring gene STARR-seq mESC enhancer starr_39292 Neighboring gene WBP2 N-terminal like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Potential target genes of EMX2 include Odz/Ten-M and other gene families with implications for cortical patterning. Li H, et al. Mol Cell Neurosci, 2006 Oct. PMID 16919471
    2. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in neuron maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    small integral membrane protein 45

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395955.1 → NP_001382884.1  small integral membrane protein 45

      Status: VALIDATED

      Source sequence(s)
      AK005178, BC094356
      UniProtKB/TrEMBL
      D3YWK9, D3YYW9
      Related
      ENSMUSP00000120070.2, ENSMUST00000143238.2
      Conserved Domains (1) summary
      PLN02960
      Location:29 → 52
      PLN02960; alpha-amylase

    2. NM_001395956.1 → NP_001382885.1  small integral membrane protein 45

      Status: VALIDATED

      Source sequence(s)
      AC104325
      UniProtKB/TrEMBL
      D3YWK9, D3YYW9
      Related
      ENSMUSP00000115748.3, ENSMUST00000136948.3
      Conserved Domains (1) summary
      PLN02960
      Location:29 → 52
      PLN02960; alpha-amylase

    RNA

    1. NR_172943.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC104325

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      82136673..82144947
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_037697.2: Suppressed sequence

      Description
      NR_037697.2: This RefSeq was removed because it is now thought that this gene does encode a protein.

    2. NR_037698.2: Suppressed sequence

      Description
      NR_037698.2: This RefSeq was removed because it is now thought that this gene does encode a protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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