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    Plekha2 pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2 [ Mus musculus (house mouse) ]

    Gene ID: 83436, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Plekha2provided by MGI
    Official Full Name
    pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2provided by MGI
    Primary source
    MGI:MGI:1928144
    See related
    Ensembl:ENSMUSG00000031557 AllianceGenome:MGI:1928144
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TAPP2; 6430512N22Rik
    Summary
    Enables PDZ domain binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Predicted to be involved in positive regulation of cell-matrix adhesion. Predicted to be located in membrane. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including bone; central nervous system; jaw; thymus primordium; and vomeronasal organ. Orthologous to human PLEKHA2 (pleckstrin homology domain containing A2). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in spleen adult (RPKM 8.9), bladder adult (RPKM 7.3) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Plekha2 in Genome Data Viewer
    Location:
    8 A2; 8 13.7 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (25529160..25594684, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (25039144..25104679, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene TM2 domain containing 2 Neighboring gene HtrA serine peptidase 4 Neighboring gene STARR-positive B cell enhancer ABC_E6628 Neighboring gene STARR-positive B cell enhancer ABC_E11381 Neighboring gene RIKEN cDNA 5830408C22 gene Neighboring gene STARR-positive B cell enhancer mm9_chr8:26213490-26213791 Neighboring gene STARR-seq mESC enhancer starr_20960 Neighboring gene STARR-positive B cell enhancer ABC_E8231 Neighboring gene STARR-positive B cell enhancer ABC_E11742 Neighboring gene STARR-positive B cell enhancer ABC_E6629 Neighboring gene STARR-seq mESC enhancer starr_20962 Neighboring gene STARR-seq mESC enhancer starr_20963 Neighboring gene predicted gene, 39143 Neighboring gene microRNA 8108 Neighboring gene transforming, acidic coiled-coil containing protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4)P2 in regulating insulin sensitivity defined by knock-in analysis. Wullschleger S, et al. Biochem J, 2011 Mar 1. PMID 21204784, Free PMC Article
    2. Interaction of TAPP adapter proteins with phosphatidylinositol (3,4)-bisphosphate regulates B-cell activation and autoantibody production. Landego I, et al. Eur J Immunol, 2012 Oct. PMID 22777911
    3. Dual inhibition of phosphoinositide 3-kinases delta and gamma reduces chronic B cell activation and autoantibody production in a mouse model of lupus. Olayinka-Adefemi F, et al. Front Immunol, 2023. PMID 37234154, Free PMC Article
    4. TAPP1 and TAPP2 are targets of phosphatidylinositol 3-kinase signaling in B cells: sustained plasma membrane recruitment triggered by the B-cell antigen receptor. Marshall AJ, et al. Mol Cell Biol, 2002 Aug. PMID 12101241, Free PMC Article
    5. B-cell-intrinsic function of TAPP adaptors in controlling germinal center responses and autoantibody production in mice. Jayachandran N, et al. Eur J Immunol, 2017 Feb. PMID 27859053

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. this study shows that TAPP1/2 double knock-out mice develop chronic germinal centers with age and show abnormal expression of B-cell activation and develop lupus-like characteristics including anti-DNA antibodies and deposition of immune complexes in kidneys
      Title: B-cell-intrinsic function of TAPP adaptors in controlling germinal center responses and autoantibody production in mice.
    2. interacts with phosphatidylinositol (3,4)-bisphosphate thus regulating B-cell activation and autoantibody production
      Title: Interaction of TAPP adapter proteins with phosphatidylinositol (3,4)-bisphosphate regulates B-cell activation and autoantibody production.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables PDZ domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables fibronectin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables laminin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-3,4-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pleckstrin homology domain-containing family A member 2
    Names
    PH domain-containing adaptor PHAD47
    PH domain-containing family A member 2
    pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2andem PH Domain containing protein 2
    tandem PH domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427346.1 → NP_001414275.1  pleckstrin homology domain-containing family A member 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC156553
      UniProtKB/Swiss-Prot
      Q8BY29, Q9ERS5
      Related
      ENSMUSP00000066546.7, ENSMUST00000064883.14

    2. NM_001427347.1 → NP_001414276.1  pleckstrin homology domain-containing family A member 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC156553
      UniProtKB/Swiss-Prot
      Q8BY29, Q9ERS5

    3. NM_001427348.1 → NP_001414277.1  pleckstrin homology domain-containing family A member 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC156553
      UniProtKB/Swiss-Prot
      Q8BY29, Q9ERS5

    4. NM_001427349.1 → NP_001414278.1  pleckstrin homology domain-containing family A member 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC156553
      UniProtKB/Swiss-Prot
      Q8BY29, Q9ERS5

    5. NM_001427350.1 → NP_001414279.1  pleckstrin homology domain-containing family A member 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC156553
      UniProtKB/Swiss-Prot
      Q8BY29, Q9ERS5

    6. NM_001427351.1 → NP_001414280.1  pleckstrin homology domain-containing family A member 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC156553

    7. NM_001427352.1 → NP_001414281.1  pleckstrin homology domain-containing family A member 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC156553

    8. NM_031257.4 → NP_112547.1  pleckstrin homology domain-containing family A member 2 isoform 1

      See identical proteins and their annotated locations for NP_112547.1

      Status: VALIDATED

      Source sequence(s)
      AC156553
      Consensus CDS
      CCDS22198.1
      UniProtKB/Swiss-Prot
      Q8BY29, Q9ERS5
      Related
      ENSMUSP00000122564.2, ENSMUST00000128715.8
      Conserved Domains (3) summary
      PHA03247
      Location:304 → 410
      PHA03247; large tegument protein UL36; Provisional
      cd13270
      Location:1 → 119
      PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
      cd13271
      Location:192 → 306
      PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      25529160..25594684 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154394.1 → XP_036010287.1  pleckstrin homology domain-containing family A member 2 isoform X1

      UniProtKB/Swiss-Prot
      Q8BY29, Q9ERS5
      Conserved Domains (3) summary
      PHA03247
      Location:304 → 410
      PHA03247; large tegument protein UL36; Provisional
      cd13270
      Location:1 → 119
      PH1_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, N-terminal repeat
      cd13271
      Location:192 → 306
      PH2_TAPP1_2; Tandem PH-domain-containing proteins 1 and 2 Pleckstrin homology (PH) domain, C-terminal repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ERS5.1 GenPept UniProtKB/Swiss-Prot:Q9ERS5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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