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    Ppih peptidyl prolyl isomerase H [ Mus musculus (house mouse) ]

    Gene ID: 66101, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Ppihprovided by MGI
    Official Full Name
    peptidyl prolyl isomerase Hprovided by MGI
    Primary source
    MGI:MGI:106499
    See related
    Ensembl:ENSMUSG00000060288 AllianceGenome:MGI:106499
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CYPH; CYP-20; D4Wsu43e; 1100001J08Rik; 2010111B15Rik; 4833408F11Rik
    Summary
    Predicted to enable cyclosporin A binding activity; peptidyl-prolyl cis-trans isomerase activity; and ribonucleoprotein complex binding activity. Predicted to be involved in positive regulation of viral genome replication; protein folding; and protein peptidyl-prolyl isomerization. Predicted to be located in nuclear speck. Predicted to be part of U4/U6 snRNP and U4/U6 x U5 tri-snRNP complex. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in several structures, including central nervous system; extraembryonic component; and retina. Orthologous to human PPIH (peptidylprolyl isomerase H). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 13.0), liver E14 (RPKM 10.6) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ppih in Genome Data Viewer
    Location:
    4 D2.1; 4 55.34 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (119157207..119177720, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (119300010..119320523, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12927 Neighboring gene claudin 19 Neighboring gene STARR-positive B cell enhancer ABC_E1652 Neighboring gene Y box protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E10252 Neighboring gene coiled-coil domain containing 30 Neighboring gene lactate dehydrogenase A, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_11233 Neighboring gene phosphopantothenoylcysteine synthetase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mus spretus LINE-1s in C57BL/6J map to at least two different chromosomes. Zhao Y, et al. Mamm Genome, 1998 Aug. PMID 9680394
    2. SAGE2Splice: unmapped SAGE tags reveal novel splice junctions. Kuo BY, et al. PLoS Comput Biol, 2006 Apr. PMID 16683015, Free PMC Article
    3. Identification of candidate lung cancer susceptibility genes in mouse using oligonucleotide arrays. Lemon WJ, et al. J Med Genet, 2002 Sep. PMID 12205107, Free PMC Article
    4. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article
    5. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, et al. Hum Mol Genet, 1998 Nov. PMID 9811942

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cyclosporin A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclosporin A binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ribonucleoprotein complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein peptidyl-prolyl isomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein peptidyl-prolyl isomerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of U4/U6 snRNP ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    peptidyl-prolyl cis-trans isomerase H
    Names
    PPIase H
    cyclophilin H
    rotamase H
    NP_001103599.1
    NP_001103600.1
    NP_082953.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110129.1 → NP_001103599.1  peptidyl-prolyl cis-trans isomerase H isoform 1

      See identical proteins and their annotated locations for NP_001103599.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has a different 3' terminal non-coding exon compared to transcript variant 1. Transcript variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK136330, AK164299, CJ071503
      Consensus CDS
      CCDS18580.1
      UniProtKB/TrEMBL
      Q3UWH9, Q4G0C5
      Related
      ENSMUSP00000101928.3, ENSMUST00000106321.9
      Conserved Domains (1) summary
      cl00197
      Location:8 → 177
      cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...

    2. NM_001110130.1 → NP_001103600.1  peptidyl-prolyl cis-trans isomerase H isoform 2

      See identical proteins and their annotated locations for NP_001103600.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has a different 3' terminal exon compared to transcript variant 1, resulting in a longer isoform (2) with a different C-terminus compared to isoform 1.
      Source sequence(s)
      AK008394, BY708305, CJ071503
      Consensus CDS
      CCDS51288.1
      UniProtKB/Swiss-Prot
      Q9CQU7, Q9D868
      UniProtKB/TrEMBL
      Q3UWH9, Q3UY37
      Related
      ENSMUSP00000101924.2, ENSMUST00000106317.2
      Conserved Domains (1) summary
      cd01926
      Location:11 → 155
      cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...

    3. NM_028677.4 → NP_082953.1  peptidyl-prolyl cis-trans isomerase H isoform 1

      See identical proteins and their annotated locations for NP_082953.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the most predominant transcript. Transcript variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK003179, BC050116, CJ071503
      Consensus CDS
      CCDS18580.1
      UniProtKB/TrEMBL
      Q3UWH9, Q4G0C5
      Related
      ENSMUSP00000101925.2, ENSMUST00000106318.8
      Conserved Domains (1) summary
      cl00197
      Location:8 → 177
      cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      119157207..119177720 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D868.1 GenPept UniProtKB/Swiss-Prot:Q9D868

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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