GIN4 protein kinase GIN4 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: GIN4
Official Full Name: protein kinase GIN4
Primary source: SGD:S000002915
Locus tag: YDR507C
See related: AllianceGenome:SGD:S000002915; FungiDB:YDR507C; VEuPathDB:YDR507C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ERC47
Summary: Enables protein kinase activity. Involved in several processes, including budding cell bud growth; mitotic morphogenesis checkpoint signaling; and septin ring assembly. Located in cellular bud neck. Orthologous to human BRSK1 (BR serine/threonine kinase 1) and BRSK2 (BR serine/threonine kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See GIN4 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (1462358..1465786, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reciprocal regulation by Elm1 and Gin4 controls septin hourglass assembly and remodeling.
Title: Reciprocal regulation by Elm1 and Gin4 controls septin hourglass assembly and remodeling.
Growth-Dependent Activation of Protein Kinases Suggests a Mechanism for Measuring Cell Growth.
Title: Growth-Dependent Activation of Protein Kinases Suggests a Mechanism for Measuring Cell Growth.
To identify unknown binding partners of Chs4, we conducted different screening approaches, which yielded several novel candidates of Chs4-binding proteins including the septin-associated kinase Gin4
Title: Septin-associated protein kinase Gin4 affects localization and phosphorylation of Chs4, the regulatory subunit of the Baker's yeast chitin synthase III complex.
Gin4 is highly localized control of membrane lipid asymmetry and is necessary for optimal cytokinesis.
Title: Protein kinase Gin4 negatively regulates flippase function and controls plasma membrane asymmetry.
A requirement for the septin Shs1 and the septin-associated kinase Gin4 for the localization and in vivo activity of the budding yeast Bnr1, is described.
Title: Regulation of the formin Bnr1 by septins anda MARK/Par1-family septin-associated kinase.
Elm1 regulates the septin assembly-dependent cellular events by directly phosphorylating and activating the Gin4-dependent pathway
Title: Direct phosphorylation and activation of a Nim1-related kinase Gin4 by Elm1 in budding yeast.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	HDA more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in budding cell bud growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in budding cell bud growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic morphogenesis checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization to cell division site	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in septin ring assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cellular bud neck	IDA Inferred from Direct Assay more info	PubMed
located_in cellular bud neck	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein kinase GIN4

NP_010795.3

EC 2.7.11.1

Protein kinase involved in bud growth and assembly of the septin ring; proposed to have kinase-dependent and kinase-independent activities; negatively regulates Fpk1p kinase that stimulates phospholipid flippases Dnf1p and Dnf2p; undergoes autophosphorylation; similar to Hsl1p; GIN4 has a paralog, KCC4, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

1462358..1465786 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180815.3 → NP_010795.3 TPA: protein kinase GIN4 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010795.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VTC9, Q12263

UniProtKB/TrEMBL

B3LFG1, N1P926

Conserved Domains (2) summary

cd12194
Location:1026 → 1139

Kcc4p_like_C; C-terminal kinase associated domain 1 (KA1), a phospholipid binding domain, of Kcc4p and similar proteins

cl21453
Location:17 → 289

PKc_like; Protein Kinases, catalytic domain