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    Gspt2 G1 to S phase transition 2 [ Mus musculus (house mouse) ]

    Gene ID: 14853, updated on 2-Nov-2024

    Summary

    Official Symbol
    Gspt2provided by MGI
    Official Full Name
    G1 to S phase transition 2provided by MGI
    Primary source
    MGI:MGI:1316727
    See related
    Ensembl:ENSMUSG00000071723 AllianceGenome:MGI:1316727
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable GTPase activity and translation release factor activity. Predicted to be involved in translational termination. Predicted to be located in cytoplasm. Predicted to be part of translation release factor complex. Is expressed in adrenal gland; central nervous system; genitourinary system; and intestine. Orthologous to human GSPT2 (G1 to S phase transition 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See Gspt2 in Genome Data Viewer
    Location:
    X C3; X 41.63 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (93679675..93682168)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (94636069..94638562)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted pseudogene 5401 Neighboring gene predicted pseudogene 9009 Neighboring gene STARR-seq mESC enhancer starr_47561 Neighboring gene STARR-seq mESC enhancer starr_47562 Neighboring gene SUMO/sentrin specific peptidase pseudogene Neighboring gene zinc finger, X-linked, duplicated B

    Genomic regions, transcripts, and products

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC143748, MGC143749

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables translation release factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables translation release factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables translation release factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in translational termination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in translational termination ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    part_of translation release factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    eukaryotic peptide chain release factor GTP-binding subunit ERF3B
    Names
    G1 to S phase transition protein 2 homolog
    eRF3b
    eukaryotic peptide chain release factor subunit 3b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008179.2NP_032205.2  eukaryotic peptide chain release factor GTP-binding subunit ERF3B

      See identical proteins and their annotated locations for NP_032205.2

      Status: VALIDATED

      Source sequence(s)
      AL645466, AW125523
      Consensus CDS
      CCDS41064.1
      UniProtKB/Swiss-Prot
      O88180, Q149F3, Q9CY91
      Related
      ENSMUSP00000109523.2, ENSMUST00000096368.4
      Conserved Domains (5) summary
      cd01883
      Location:209425
      EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family
      COG5256
      Location:205629
      TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
      pfam07145
      Location:5471
      PAM2; Ataxin-2 C-terminal region
      cd04089
      Location:434514
      eRF3_II; Domain II of the eukaryotic class II release factor
      cd03704
      Location:521627
      eRF3_C_III; C-terminal domain of eRF3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      93679675..93682168
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)