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    FHL1 four and a half LIM domains 1 [ Homo sapiens (human) ]

    Gene ID: 2273, updated on 10-Dec-2024

    Summary

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    Official Symbol
    FHL1provided by HGNC
    Official Full Name
    four and a half LIM domains 1provided by HGNC
    Primary source
    HGNC:HGNC:3702
    See related
    Ensembl:ENSG00000022267 MIM:300163; AllianceGenome:HGNC:3702
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KYOT; SLIM; FCMSU; FHL-1; FHL1A; FHL1B; FLH1A; SLIM1; XMPMA; RBMX1A; RBMX1B; SLIM-1; SLIMMER
    Summary
    This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. Expression of these family members occurs in a cell- and tissue-specific mode and these proteins are involved in many cellular processes. Mutations in this gene have been found in patients with Emery-Dreifuss muscular dystrophy. Multiple alternately spliced transcript variants which encode different protein isoforms have been described.[provided by RefSeq, Nov 2009]
    Expression
    Broad expression in heart (RPKM 286.6), fat (RPKM 281.6) and 18 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FHL1 in Genome Data Viewer
    Location:
    Xq26.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (136146702..136211359)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (134455091..134519750)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (135228861..135293518)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:135179522-135180721 Neighboring gene E2F transcription factor 6 pseudogene 4 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:135196669-135196868 Neighboring gene small nucleolar RNA U13 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chrX:135225551-135226750 Neighboring gene Sharpr-MPRA regulatory region 1893 Neighboring gene MAP7 domain containing 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21026 Neighboring gene serine/threonine kinase 24 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of factor H-like protein 1 as the predominant complement regulator in Bruch's membrane: implications for age-related macular degeneration. Clark SJ, et al. J Immunol, 2014 Nov 15. PMID 25305316, Free PMC Article
    2. Reducing bodies and myofibrillar myopathy features in FHL1 muscular dystrophy. Selcen D, et al. Neurology, 2011 Nov 29. PMID 22094483, Free PMC Article
    3. Expression of FHL1 in gastric cancer tissue and its correlation with the invasion and metastasis of gastric cancer. Xu Y, et al. Mol Cell Biochem, 2012 Apr. PMID 22143536
    4. Selective muscle involvement in a family affected by a second LIM domain mutation of fhl1: an imaging study using computed tomography. Komagamine T, et al. J Neurol Sci, 2012 Jul 15. PMID 22541254
    5. FHL1 on chromosome X is a single-hit gastrointestinal tumor-suppressor gene and contributes to the formation of an epigenetic field defect. Asada K, et al. Oncogene, 2013 Apr 25. PMID 22689052

    See all (174) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FHL1: A novel diagnostic marker for papillary thyroid carcinoma.
      Title: FHL1: A novel diagnostic marker for papillary thyroid carcinoma.
    2. Low FHL1 expression indicates a good prognosis and drug sensitivity in ovarian cancer.
      Title: Low FHL1 expression indicates a good prognosis and drug sensitivity in ovarian cancer.
    3. Immortalization-upregulated protein promotes pancreatic cancer progression by regulating NPM1/FHL1-mediated cell-cycle-checkpoint protein activity.
      Title: Immortalization-upregulated protein promotes pancreatic cancer progression by regulating NPM1/FHL1-mediated cell-cycle-checkpoint protein activity.
    4. Identification of novel FHL1 mutations associated with X-linked scapuloperoneal myopathy in unrelated Chinese patients.
      Title: Identification of novel FHL1 mutations associated with X-linked scapuloperoneal myopathy in unrelated Chinese patients.
    5. Preferential production and secretion of the complement regulator factor H-like protein 1 (FHL-1) by human myeloid cells.
      Title: Preferential production and secretion of the complement regulator factor H-like protein 1 (FHL-1) by human myeloid cells.
    6. FHL1 as a novel prognostic biomarker and correlation with immune infiltration levels in lung adenocarcinoma.
      Title: FHL1 as a novel prognostic biomarker and correlation with immune infiltration levels in lung adenocarcinoma.
    7. Targeting FHL1 impairs cell proliferation and differentiation of acute myeloid leukemia cells.
      Title: Targeting FHL1 impairs cell proliferation and differentiation of acute myeloid leukemia cells.
    8. MiR-96-5p Facilitates Lung Adenocarcinoma Cell Phenotypes by Inhibiting FHL1.
      Title: MiR-96-5p Facilitates Lung Adenocarcinoma Cell Phenotypes by Inhibiting FHL1.
    9. Upregulation of FHL1, SPNS3, and MPZL2 predicts poor prognosis in pediatric acute myeloid leukemia patients with FLT3-ITD mutation.
      Title: Upregulation of FHL1, SPNS3, and MPZL2 predicts poor prognosis in pediatric acute myeloid leukemia patients with FLT3-ITD mutation.
    10. Three novel FHL1 variants cause a mild phenotype of Emery-Dreifuss muscular dystrophy.
      Title: Three novel FHL1 variants cause a mild phenotype of Emery-Dreifuss muscular dystrophy.
    Submit: New GeneRIF Correction See all GeneRIFs (84)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Myopathy, reducing body, X-linked, childhood-onset
    MedGen: C4225159 OMIM: 300718 GeneReviews: Not available
    		not available
    Myopathy, reducing body, X-linked, early-onset, severe
    MedGen: C4225423 OMIM: 300717 GeneReviews: Not available
    		not available
    Uruguay Faciocardiomusculoskeletal syndrome
    MedGen: C1846010 OMIM: 300280 GeneReviews: Not available
    		not available
    X-linked myopathy with postural muscle atrophy
    MedGen: C2678055 OMIM: 300696 GeneReviews: Emery-Dreifuss Muscular Dystrophy
    		not available
    X-linked scapuloperoneal muscular dystrophy
    MedGen: C2678061 OMIM: 300695 GeneReviews: Not available
    		not available

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC111107

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in muscle organ development NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of G1/S transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of G2/M transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of potassium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of membrane depolarization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of potassium ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in focal adhesion HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    four and a half LIM domains protein 1
    Names
    LIM protein SLIMMER
    four-and-a-half Lin11, Isl-1 and Mec-3 domains 1
    skeletal muscle LIM-protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_015895.1 RefSeqGene

      Range
      5134..68955
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_739

    mRNA and Protein(s)

    1. NM_001159699.2 → NP_001153171.1  four and a half LIM domains protein 1 isoform 5

      See identical proteins and their annotated locations for NP_001153171.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, 3' UTR, and 3' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded protein (isoform 5) has distinct N- and C-termini and is shorter than isoform 1.
      Source sequence(s)
      BC088369, BM995585, DC373386
      Consensus CDS
      CCDS55506.1
      UniProtKB/TrEMBL
      Q53FI7
      Related
      ENSP00000359717.1, ENST00000370683.6
      Conserved Domains (5) summary
      cd09344
      Location:56 → 109
      LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
      cd09348
      Location:233 → 296
      LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09424
      Location:117 → 174
      LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09429
      Location:178 → 230
      LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cl02475
      Location:21 → 49
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    2. NM_001159700.2 → NP_001153172.1  four and a half LIM domains protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001153172.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, 3' UTR, and 3' coding region compared to variant 1. The encoded protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4 and 9 encode the same protein (isoform 2).
      Source sequence(s)
      AK304680, AL078638, BC088369, BM995585, DC363191
      Consensus CDS
      CCDS14655.1
      UniProtKB/TrEMBL
      Q53FI7
      Related
      ENSP00000485897.1, ENST00000630084.2
      Conserved Domains (5) summary
      cd09344
      Location:40 → 93
      LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
      cd09348
      Location:217 → 280
      LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09424
      Location:101 → 158
      LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09429
      Location:162 → 214
      LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cl02475
      Location:5 → 33
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    3. NM_001159701.2 → NP_001153173.1  four and a half LIM domains protein 1 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001153173.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, 3' UTR, and coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded protein (isoform 3) is shorter and has distinct N- and C-termini, compared to isoform 1.
      Source sequence(s)
      AK301642, BC010998, BM995585
      Consensus CDS
      CCDS55505.1
      UniProtKB/TrEMBL
      Q53FI7
      Related
      ENSP00000437673.1, ENST00000539015.5
      Conserved Domains (5) summary
      cd09344
      Location:69 → 122
      LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
      cd09348
      Location:246 → 309
      LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09424
      Location:130 → 187
      LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09429
      Location:191 → 243
      LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cl02475
      Location:34 → 62
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    4. NM_001159702.3 → NP_001153174.1  four and a half LIM domains protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001153174.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
      Source sequence(s)
      AF063002, AF098518, BC010998, BM995585
      Consensus CDS
      CCDS55507.1
      UniProtKB/Swiss-Prot
      B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630
      Related
      ENSP00000377710.2, ENST00000394155.8
      Conserved Domains (4) summary
      cd09344
      Location:40 → 93
      LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
      cd09424
      Location:101 → 158
      LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09429
      Location:162 → 214
      LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cl02475
      Location:5 → 33
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    5. NM_001159703.2 → NP_001153175.1  four and a half LIM domains protein 1 isoform 4

      See identical proteins and their annotated locations for NP_001153175.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding region, compared to variant 1. The encoded protein (isoform 4) is shorter than isoform 1.
      Source sequence(s)
      AF220153, AK301642, AL078638, BC010998, BE965488, BM995585, DA497183
      Consensus CDS
      CCDS76036.1
      UniProtKB/TrEMBL
      A0A0D9SFZ9
      Related
      ENSP00000477609.1, ENST00000618438.4
      Conserved Domains (3) summary
      cd09344
      Location:40 → 93
      LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
      cd09424
      Location:101 → 158
      LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cl02475
      Location:5 → 33
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    6. NM_001159704.1 → NP_001153176.1  four and a half LIM domains protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001153176.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, 3' UTR, and 3' coding region compared to variant 1. The encoded protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4 and 9 encode the same protein (isoform 2).
      Source sequence(s)
      AK122708, AL078638, BM995585
      Consensus CDS
      CCDS14655.1
      UniProtKB/TrEMBL
      Q53FI7
      Related
      ENSP00000443333.1, ENST00000543669.5
      Conserved Domains (5) summary
      cd09344
      Location:40 → 93
      LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
      cd09348
      Location:217 → 280
      LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09424
      Location:101 → 158
      LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09429
      Location:162 → 214
      LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cl02475
      Location:5 → 33
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    7. NM_001167819.1 → NP_001161291.1  four and a half LIM domains protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001161291.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) uses a different segment for its 5' UTR and lacks an alternate exon in the 3' coding region, compared to variant 1. The encoded protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4 and 9 encode the same protein (isoform 2).
      Source sequence(s)
      BC010998, BM995585, DA917361, DA982372
      Consensus CDS
      CCDS14655.1
      UniProtKB/TrEMBL
      Q53FI7
      Related
      ENSP00000377709.2, ENST00000394153.6
      Conserved Domains (5) summary
      cd09344
      Location:40 → 93
      LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
      cd09348
      Location:217 → 280
      LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09424
      Location:101 → 158
      LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09429
      Location:162 → 214
      LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cl02475
      Location:5 → 33
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    8. NM_001330659.2 → NP_001317588.1  four and a half LIM domains protein 1 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) uses an alternate 5'-terminal exon, lacks two in-frame exons in the 3' coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (6) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AL078638
      Consensus CDS
      CCDS83493.1
      UniProtKB/TrEMBL
      A0A0D9SFZ9, Q5JXI2
      Related
      ENSP00000359710.3, ENST00000370676.7
      Conserved Domains (3) summary
      cd09344
      Location:56 → 109
      LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
      cd09424
      Location:117 → 174
      LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cl02475
      Location:21 → 49
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    9. NM_001369326.1 → NP_001356255.1  four and a half LIM domains protein 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL078638
      Consensus CDS
      CCDS55507.1
      UniProtKB/Swiss-Prot
      B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630
      Related
      ENSP00000498684.1, ENST00000651089.1
      Conserved Domains (4) summary
      cd09344
      Location:40 → 93
      LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
      cd09424
      Location:101 → 158
      LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09429
      Location:162 → 214
      LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cl02475
      Location:5 → 33
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    10. NM_001369327.2 → NP_001356256.1  four and a half LIM domains protein 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL078638
      Consensus CDS
      CCDS55507.1
      UniProtKB/Swiss-Prot
      B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630
      Conserved Domains (4) summary
      cd09344
      Location:40 → 93
      LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
      cd09424
      Location:101 → 158
      LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09429
      Location:162 → 214
      LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cl02475
      Location:5 → 33
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    11. NM_001369328.1 → NP_001356257.1  four and a half LIM domains protein 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL078638
      Consensus CDS
      CCDS55507.1
      UniProtKB/Swiss-Prot
      B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630
      Conserved Domains (4) summary
      cd09344
      Location:40 → 93
      LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
      cd09424
      Location:101 → 158
      LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09429
      Location:162 → 214
      LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cl02475
      Location:5 → 33
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    12. NM_001369329.1 → NP_001356258.1  four and a half LIM domains protein 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL078638
      Consensus CDS
      CCDS14655.1
      UniProtKB/TrEMBL
      Q53FI7
      Conserved Domains (5) summary
      cd09344
      Location:40 → 93
      LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
      cd09348
      Location:217 → 280
      LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09424
      Location:101 → 158
      LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09429
      Location:162 → 214
      LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cl02475
      Location:5 → 33
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    13. NM_001369330.1 → NP_001356259.1  four and a half LIM domains protein 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL078638
      Consensus CDS
      CCDS14655.1
      UniProtKB/TrEMBL
      Q53FI7
      Related
      ENSP00000444815.1, ENST00000535737.5
      Conserved Domains (5) summary
      cd09344
      Location:40 → 93
      LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
      cd09348
      Location:217 → 280
      LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09424
      Location:101 → 158
      LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09429
      Location:162 → 214
      LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cl02475
      Location:5 → 33
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    14. NM_001369331.1 → NP_001356260.1  four and a half LIM domains protein 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL078638
      Consensus CDS
      CCDS14655.1
      UniProtKB/TrEMBL
      Q53FI7
      Related
      ENSP00000359708.1, ENST00000370674.3
      Conserved Domains (5) summary
      cd09344
      Location:40 → 93
      LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
      cd09348
      Location:217 → 280
      LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09424
      Location:101 → 158
      LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09429
      Location:162 → 214
      LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cl02475
      Location:5 → 33
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    15. NM_001449.5 → NP_001440.2  four and a half LIM domains protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001440.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR, and 3' coding region compared to variant 1. The encoded protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4 and 9 encode the same protein (isoform 2).
      Source sequence(s)
      BC010998, BM995585
      Consensus CDS
      CCDS14655.1
      UniProtKB/TrEMBL
      Q53FI7
      Related
      ENSP00000499016.1, ENST00000651929.2
      Conserved Domains (5) summary
      cd09344
      Location:40 → 93
      LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
      cd09348
      Location:217 → 280
      LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09424
      Location:101 → 158
      LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09429
      Location:162 → 214
      LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cl02475
      Location:5 → 33
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    RNA

    1. NR_027621.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) includes an additional exon at the 5' end, compared to variant 1. This variant is represented as non-coding because it contains an upstream ORF that is predicted to interfere with translation of the downstream expected ORF as used in variant 1.
      Source sequence(s)
      AK289411, AL078638, BC010998, BM995585

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      136146702..136211359
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047441926.1 → XP_047297882.1  four and a half LIM domains protein 1 isoform X2

      UniProtKB/Swiss-Prot
      B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630

    2. XM_047441927.1 → XP_047297883.1  four and a half LIM domains protein 1 isoform X3

      UniProtKB/TrEMBL
      Q53FI7

    3. XM_024452354.2 → XP_024308122.1  four and a half LIM domains protein 1 isoform X2

      UniProtKB/Swiss-Prot
      B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630
      Conserved Domains (4) summary
      cd09344
      Location:40 → 93
      LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
      cd09424
      Location:101 → 158
      LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09429
      Location:162 → 214
      LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cl02475
      Location:5 → 33
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    4. XM_047441925.1 → XP_047297881.1  four and a half LIM domains protein 1 isoform X2

      UniProtKB/Swiss-Prot
      B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630

    5. XM_006724743.3 → XP_006724806.1  four and a half LIM domains protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006724806.1

      Conserved Domains (4) summary
      cd09344
      Location:56 → 109
      LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
      cd09424
      Location:117 → 174
      LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09429
      Location:178 → 230
      LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cl02475
      Location:21 → 49
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    6. XM_006724746.4 → XP_006724809.1  four and a half LIM domains protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006724809.1

      UniProtKB/Swiss-Prot
      B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630
      Conserved Domains (4) summary
      cd09344
      Location:40 → 93
      LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
      cd09424
      Location:101 → 158
      LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09429
      Location:162 → 214
      LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cl02475
      Location:5 → 33
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      134455091..134519750
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326701.1 → XP_054182676.1  four and a half LIM domains protein 1 isoform X2

      UniProtKB/Swiss-Prot
      B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630

    2. XM_054326702.1 → XP_054182677.1  four and a half LIM domains protein 1 isoform X3

      UniProtKB/TrEMBL
      Q53FI7

    3. XM_054326700.1 → XP_054182675.1  four and a half LIM domains protein 1 isoform X2

      UniProtKB/Swiss-Prot
      B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630

    4. XM_054326699.1 → XP_054182674.1  four and a half LIM domains protein 1 isoform X2

      UniProtKB/Swiss-Prot
      B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630

    5. XM_054326697.1 → XP_054182672.1  four and a half LIM domains protein 1 isoform X1

    6. XM_054326698.1 → XP_054182673.1  four and a half LIM domains protein 1 isoform X2

      UniProtKB/Swiss-Prot
      B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13642.4 GenPept UniProtKB/Swiss-Prot:Q13642

    Gene LinkOut

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