Cnnm1 cyclin and CBS domain divalent metal cation transport mediator 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cnnm1provided by RGD
Official Full Name: cyclin and CBS domain divalent metal cation transport mediator 1provided by RGD
Primary source: RGD:1308728
See related: EnsemblRapid:ENSRNOG00000016302 AllianceGenome:RGD:1308728
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable transmembrane transporter activity. Predicted to be involved in magnesium ion homeostasis; monoatomic ion transport; and transmembrane transport. Predicted to be located in dendrite; neuronal cell body; and plasma membrane. Orthologous to human CNNM1 (cyclin and CBS domain divalent metal cation transport mediator 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 79.1), Heart (RPKM 35.0) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q54

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (252245377..252304205)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (242296367..242354957)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (263184361..263243912)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH138210 (e-PCR)
- UniSTS:220297

AI169450 (e-PCR)
- UniSTS:250296

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in magnesium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in magnesium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: metal transporter CNNM1

Names: cyclin M1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107593.2 → NP_001101063.2 metal transporter CNNM1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I6ATT3

Related

ENSRNOP00000096701.1, ENSRNOT00000117490.2
NM_001401623.1 → NP_001388552.1 metal transporter CNNM1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I6G7K3

Related

ENSRNOP00000082560.1, ENSRNOT00000113055.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

252245377..252304205

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039080142.2 → XP_038936070.1 metal transporter CNNM1 isoform X3

Conserved Domains (1) summary

COG1253
Location:251 → 553

TlyC; Hemolysin or related protein, contains CBS domains [General function prediction only]
XM_039080138.2 → XP_038936066.1 metal transporter CNNM1 isoform X2

Conserved Domains (1) summary

COG1253
Location:251 → 553

TlyC; Hemolysin or related protein, contains CBS domains [General function prediction only]
XM_008760426.4 → XP_008758648.1 metal transporter CNNM1 isoform X1

Related

ENSRNOP00000021876.8, ENSRNOT00000021876.8

Conserved Domains (3) summary

COG0517
Location:429 → 553

CBS; CBS domain [Signal transduction mechanisms]

cd04590
Location:438 → 553

CBS_pair_CorC_HlyC_assoc; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in ...

pfam01595
Location:237 → 414

DUF21; Domain of unknown function DUF21