Rars1 arginyl-tRNA synthetase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rars1provided by RGD
Official Full Name: arginyl-tRNA synthetase 1provided by RGD
Primary source: RGD:1309215
See related: EnsemblRapid:ENSRNOG00000007739 AllianceGenome:RGD:1309215
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rars
Summary: Enables anion binding activity; arginine-tRNA ligase activity; and tRNA binding activity. Involved in arginyl-tRNA aminoacylation. Part of aminoacyl-tRNA synthetase multienzyme complex. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 9. Orthologous to human RARS1 (arginyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 255.7), Thymus (RPKM 227.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (20774804..20799251, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (20270744..20295192, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (20633630..20658074, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The expression levels of ArgRS mRNA and protein in ischemic penumbra varied with ischemic time, suggesting that the energy metabolism of brain cells in penumbra changed dynamically after ischemia to ensure the endogenous self-protection of the body
Title: Expression of arginyl-tRNA synthetase in rats with focal cerebral ischemia.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables arginine binding	IDA Inferred from Direct Assay more info	PubMed
enables arginine-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arginine-tRNA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables arginine-tRNA ligase activity	ISO Inferred from Sequence Orthology more info
enables tRNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in arginyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in arginyl-tRNA aminoacylation	IDA Inferred from Direct Assay more info	PubMed
involved_in arginyl-tRNA aminoacylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of aminoacyl-tRNA synthetase multienzyme complex	IDA Inferred from Direct Assay more info	PubMed
part_of aminoacyl-tRNA synthetase multienzyme complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: arginine--tRNA ligase, cytoplasmic

Names: argRS; arginyl-tRNA synthetase, cytoplasmic

NP_001099247.2

EC 6.1.1.19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105777.2 → NP_001099247.2 arginine--tRNA ligase, cytoplasmic

See identical proteins and their annotated locations for NP_001099247.2

Status: VALIDATED

Source sequence(s)

BF420005, CB313613, CF110623

UniProtKB/Swiss-Prot

B1WBX8, P40329

UniProtKB/TrEMBL

A6HDJ0

Related

ENSRNOP00000010252.4, ENSRNOT00000010252.8

Conserved Domains (4) summary

cd00671
Location:193 → 457

ArgRS_core; catalytic core domain of arginyl-tRNA synthetases

smart01016
Location:79 → 166

Arg_tRNA_synt_N; Arginyl tRNA synthetase N terminal dom

PLN02286
Location:80 → 660

PLN02286; arginine-tRNA ligase

cl12020
Location:498 → 660

Anticodon_Ia_like; Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains