Mapk10 mitogen activated protein kinase 10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mapk10provided by RGD
Official Full Name: mitogen activated protein kinase 10provided by RGD
Primary source: RGD:3663
See related: EnsemblRapid:ENSRNOG00000002079 AllianceGenome:RGD:3663
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Jnk3; SAPb; SAPKC; Serk2
Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
Expression: Biased expression in Brain (RPKM 116.3), Testes (RPKM 7.1) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 14p22

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (6802247..7094103)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (6497662..6790109)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (8079955..8371508)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Accelerating bone healing in vivo by harnessing the age-altered activation of c-Jun N-terminal kinase 3.
Title: Accelerating bone healing in vivo by harnessing the age-altered activation of c-Jun N-terminal kinase 3.
The Map3k12 (Dlk)/JNK3 signaling pathway is required for pancreatic beta-cell proliferation during postnatal development.
Title: The Map3k12 (Dlk)/JNK3 signaling pathway is required for pancreatic beta-cell proliferation during postnatal development.
results indicate that Wnt5a-mediated JNK3 activation participates in Ischemia/Reperfusion brain injury by targeting the Dvl-1-beta-arrestin2/JNK3 interaction
Title: Targeting the Dvl-1/β-arrestin2/JNK3 interaction disrupts Wnt5a-JNK3 signaling and protects hippocampal CA1 neurons during cerebral ischemia reperfusion.
A novel interaction between KLF9 and JNK3, contributes to axon growth suppression and inhibition of axon regeneration.
Title: KLF9 and JNK3 Interact to Suppress Axon Regeneration in the Adult CNS.
Results suggest that cilostazol could protect hippocampal neurons and ameliorate the impairment of learning/memory abilities and locomotor/exploratory activities in ischemic stroke via a PI3K-Akt1/JNK3/caspase-3 dependent mechanism
Title: Neuroprotection of Cilostazol against ischemia/reperfusion-induced cognitive deficits through inhibiting JNK3/caspase-3 by enhancing Akt1.
In hippocampal neurons, BDNF up-regulates JIP3 expression via CREB activation.
Title: Up-regulation of c-Jun NH2-terminal kinase-interacting protein 3 (JIP3) contributes to BDNF-enhanced neurotransmitter release.
JNK3 phosphorylatesrRat brain mitochondrial VDAC channel, which leads to the channel closure.
Title: Phosphorylation of voltage-dependent anion channel by c-Jun N-terminal Kinase-3 leads to closure of the channel.
Rotenone induces dopamine neuron death through a series of sequential events including microtubule destabilization, JNK3 activation, VMAT2 inhibition, accumulation of cytosolic dopamine, and generation of ROS.
Title: JNK inhibition of VMAT2 contributes to rotenone-induced oxidative stress and dopamine neuron death.
JNK3 participates in an adaptive response to neuronal hyperexcitation by impeding secretory trafficking at the Golgi complex.
Title: JNK3 couples the neuronal stress response to inhibition of secretory trafficking.
Akt1 activation is involved in the neuroprotection of HSP72 against ischemic brain injury via suppressing JNK3 signaling pathway, providing a new experimental foundation for stroke therapy.
Title: Heat shock protein 72 inhibits c-Jun N-terminal kinase 3 signaling pathway via Akt1 during cerebral ischemia.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:532281

Mapk10 (e-PCR), detects polymorphism
- UniSTS:532281

RH131900 (e-PCR)
- UniSTS:215183

RH139507 (e-PCR)
- UniSTS:221593

RH137759 (e-PCR)
- UniSTS:219846

RH140337 (e-PCR)
- UniSTS:222413

BE120200 (e-PCR)
- UniSTS:247266

BF393702 (e-PCR)
- UniSTS:244217

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables JUN kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables JUN kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables JUN kinase activity	IEA Inferred from Electronic Annotation more info
enables JUN kinase activity	ISO Inferred from Sequence Orthology more info
enables JUN kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in JNK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in JNK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in JUN phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular hyperosmotic response	IEP Inferred from Expression Pattern more info	PubMed
involved_in locomotor rhythm	ISO Inferred from Sequence Orthology more info
involved_in locomotor rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in neurotransmitter receptor transport to postsynaptic membrane	EXP Inferred from Experiment more info	PubMed
involved_in neurotransmitter receptor transport to postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in neurotransmitter receptor transport to postsynaptic membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to light stimulus	ISO Inferred from Sequence Orthology more info
involved_in response to light stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport in synapse	EXP Inferred from Experiment more info	PubMed
involved_in vesicle-mediated transport in synapse	IDA Inferred from Direct Assay more info	PubMed
involved_in vesicle-mediated transport in synapse	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic Golgi apparatus	IMP Inferred from Mutant Phenotype more info	PubMed
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitogen-activated protein kinase 10

Names: MAP kinase 10; MAPK 10; SAPK-beta; Stress activated protein kinase beta; c-Jun N-terminal kinase 3; p54-beta; stress-activated protein kinase JNK3

NP_001257485.1

EC 2.7.11.24

NP_001305119.1

EC 2.7.11.24

NP_036938.2

EC 2.7.11.24

XP_017454572.1

EC 2.7.11.24

XP_017454573.1

EC 2.7.11.24

XP_063128936.1

EC 2.7.11.24

XP_063128937.1

EC 2.7.11.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270556.1 → NP_001257485.1 mitogen-activated protein kinase 10 isoform 1

See identical proteins and their annotated locations for NP_001257485.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the shorter isoform (1).

Source sequence(s)

FQ083521, FQ084081, FQ211777

UniProtKB/Swiss-Prot

B0VXR6, D3ZQ33, P49187

UniProtKB/TrEMBL

A6K5V7

Related

ENSRNOP00000075846.3, ENSRNOT00000092395.3

Conserved Domains (1) summary

cd07850
Location:63 → 398

STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
NM_001318190.1 → NP_001305119.1 mitogen-activated protein kinase 10 isoform 1x

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the longer, C-terminally extended isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), the location of the upstream UGA stop codon in the longer isoform is denoted by an 'X'.

Source sequence(s)

FQ083521, FQ084081, FQ211777

UniProtKB/Swiss-Prot

B0VXR6, D3ZQ33, P49187

Conserved Domains (2) summary

smart00220
Location:64 → 359

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07850
Location:63 → 398

STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
NM_012806.2 → NP_036938.2 mitogen-activated protein kinase 10 isoform 2

See identical proteins and their annotated locations for NP_036938.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate acceptor splice site in the 5' region, which results in translation initiation from an in-frame, downstream start codon compared to variant 1. The encoded isoform (2, also known as SAPK beta) has a shorter N-terminus compared to isoform 1.

Source sequence(s)

FQ083521, FQ084081, FQ211777, L27128

UniProtKB/TrEMBL

A0A8L2RB61

Conserved Domains (1) summary

cd07850
Location:25 → 360

STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

6802247..7094103

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272867.1 → XP_063128937.1 mitogen-activated protein kinase 10 isoform X3

UniProtKB/TrEMBL

A0A0U1RVI2

Related

ENSRNOP00000060904.5, ENSRNOT00000065965.6
XM_017599084.3 → XP_017454573.1 mitogen-activated protein kinase 10 isoform X2

UniProtKB/TrEMBL

A0A0U1RRS7

Related

ENSRNOP00000075755.3, ENSRNOT00000092719.3

Conserved Domains (1) summary

cd07850
Location:63 → 398

STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
XM_017599083.3 → XP_017454572.1 mitogen-activated protein kinase 10 isoform X1

UniProtKB/TrEMBL

A0A8L2RB61

Conserved Domains (1) summary

cd07850
Location:25 → 360

STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
XM_063272866.1 → XP_063128936.1 mitogen-activated protein kinase 10 isoform X2

Related

ENSRNOP00000109602.1, ENSRNOT00000169826.1