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    HIPK3 homeodomain interacting protein kinase 3 [ Homo sapiens (human) ]

    Gene ID: 10114, updated on 10-Dec-2024

    Summary

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    Official Symbol
    HIPK3provided by HGNC
    Official Full Name
    homeodomain interacting protein kinase 3provided by HGNC
    Primary source
    HGNC:HGNC:4915
    See related
    Ensembl:ENSG00000110422 MIM:604424; AllianceGenome:HGNC:4915
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PKY; YAK1; DYRK6; FIST3
    Summary
    Enables protein serine/threonine kinase activity. Involved in mRNA transcription; negative regulation of apoptotic process; and protein phosphorylation. Located in cytosol; nuclear body; and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in fat (RPKM 29.7), gall bladder (RPKM 21.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See HIPK3 in Genome Data Viewer
    Location:
    11p13
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (33256672..33357023)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (33392109..33492540)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (33278218..33378569)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene CSTF3 divergent transcript Neighboring gene ribosomal protein L29 pseudogene 23 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3232 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3233 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4575 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4576 Neighboring gene ribosomal protein S24 pseudogene 15 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3235 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3236 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3237 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3238 Neighboring gene KIAA1549 like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4577 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4578 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4579 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4581 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:33666983-33667484 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:33667485-33667984 Neighboring gene uncharacterized LOC105376617 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:33676703-33677902 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4582 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:33711673-33712872 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3239 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3240 Neighboring gene chromosome 11 open reading frame 91 Neighboring gene CD59 molecule (CD59 blood group)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. HIPK3 maintains sensitivity to platinum drugs and prevents disease progression in gastric cancer. Wu QN, et al. Cancer Lett, 2024 Mar 1. PMID 38246220
    2. Identification and sequence of human PKY, a putative kinase with increased expression in multidrug-resistant cells, with homology to yeast protein kinase Yak1. Begley DA, et al. Gene, 1997 Oct 24. PMID 9373137
    3. Assignment of the protein kinase homolog of YAK1 (HIPK3) to human chromosome band 11p13 by in situ hybridization. Nupponen NN, et al. Cytogenet Cell Genet, 1999. PMID 10640824
    4. HIPK3 modulates autophagy and HTT protein levels in neuronal and mouse models of Huntington disease. Fu Y, et al. Autophagy, 2018. PMID 29130397, Free PMC Article
    5. CircHIPK3 is upregulated and predicts a poor prognosis in epithelial ovarian cancer. Liu N, et al. Eur Rev Med Pharmacol Sci, 2018 Jun. PMID 29949144

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CircHIPK3/miR-124 affects angiogenesis in early-onset preeclampsia via CPT1A-mediated fatty acid oxidation.
      Title: CircHIPK3/miR-124 affects angiogenesis in early-onset preeclampsia via CPT1A-mediated fatty acid oxidation.
    2. HIPK3 maintains sensitivity to platinum drugs and prevents disease progression in gastric cancer.
      Title: HIPK3 maintains sensitivity to platinum drugs and prevents disease progression in gastric cancer.
    3. Overexpression of microRNA-205-5p promotes cholangiocarcinoma growth by reducing expression of homeodomain-interacting protein kinase 3.
      Title: Overexpression of microRNA-205-5p promotes cholangiocarcinoma growth by reducing expression of homeodomain-interacting protein kinase 3.
    4. CircHIPK3 relieves vascular calcification via mediating SIRT1/PGC-1alpha/MFN2 pathway by interacting with FUS.
      Title: CircHIPK3 relieves vascular calcification via mediating SIRT1/PGC-1α/MFN2 pathway by interacting with FUS.
    5. Circular RNA HIPK3 facilitates ferroptosis in gestational diabetes mellitus by regulating glutathione peroxidase 4 DNA methylation.
      Title: Circular RNA HIPK3 facilitates ferroptosis in gestational diabetes mellitus by regulating glutathione peroxidase 4 DNA methylation.
    6. DNA methylation change of HIPK3 in Chinese rheumatoid arthritis and its effect on inflammation.
      Title: DNA methylation change of HIPK3 in Chinese rheumatoid arthritis and its effect on inflammation.
    7. circHIPK3 prevents cardiac senescence by acting as a scaffold to recruit ubiquitin ligase to degrade HuR.
      Title: circHIPK3 prevents cardiac senescence by acting as a scaffold to recruit ubiquitin ligase to degrade HuR.
    8. Circ_0060,144 inhibits the occurrence and development of age-related cataract via the miR-23b-3p/HIPK3 axis.
      Title: Circ_0060,144 inhibits the occurrence and development of age-related cataract via the miR-23b-3p/HIPK3 axis.
    9. CircHIPK3 prevents chondrocyte apoptosis and cartilage degradation by sponging miR-30a-3p and promoting PON2.
      Title: CircHIPK3 prevents chondrocyte apoptosis and cartilage degradation by sponging miR-30a-3p and promoting PON2.
    10. CircHIPK3 contributes to human villous trophoblast growth, migration and invasion via modulating the pathway of miR-346/KCMF1.
      Title: CircHIPK3 contributes to human villous trophoblast growth, migration and invasion via modulating the pathway of miR-346/KCMF1.
    Submit: New GeneRIF Correction See all GeneRIFs (42)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of proneness to anger.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of JUN kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidyl-serine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in peptidyl-threonine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in PML body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    homeodomain-interacting protein kinase 3
    Names
    ANPK
    FIST
    androgen receptor-interacting nuclear protein kinase
    fas-interacting serine/threonine-protein kinase
    homolog of protein kinase YAK1
    NP_001041665.1
    NP_001265091.1
    NP_001265092.1
    NP_005725.3
    XP_047282179.1
    XP_047282180.1
    XP_047282181.1
    XP_054223402.1
    XP_054223403.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001048200.3 → NP_001041665.1  homeodomain-interacting protein kinase 3 isoform 2

      See identical proteins and their annotated locations for NP_001041665.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the central region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1. Variants 2, 3 and 4 encode the same isoform 2.
      Source sequence(s)
      AK315277, AL122015, BX117467, DR000092, HY053621
      Consensus CDS
      CCDS41634.1
      UniProtKB/TrEMBL
      A8KAE4
      Related
      ENSP00000368301.3, ENST00000379016.7
      Conserved Domains (2) summary
      smart00220
      Location:197 → 525
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14229
      Location:196 → 525
      STKc_HIPK3; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 3

    2. NM_001278162.2 → NP_001265091.1  homeodomain-interacting protein kinase 3 isoform 2

      See identical proteins and their annotated locations for NP_001265091.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an in-frame exon in the central region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1. Variants 2, 3 and 4 encode the same isoform 2.
      Source sequence(s)
      AK293009, AK315277, AL122015, AL136126, BX117467
      Consensus CDS
      CCDS41634.1
      UniProtKB/TrEMBL
      A8KAE4
      Related
      ENSP00000398241.1, ENST00000456517.2
      Conserved Domains (2) summary
      smart00220
      Location:197 → 525
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14229
      Location:196 → 525
      STKc_HIPK3; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 3

    3. NM_001278163.2 → NP_001265092.1  homeodomain-interacting protein kinase 3 isoform 2

      See identical proteins and their annotated locations for NP_001265092.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame exon in the central region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1. Variants 2, 3 and 4 encode the same isoform 2.
      Source sequence(s)
      AK315277, AL122015, BX117467
      Consensus CDS
      CCDS41634.1
      UniProtKB/TrEMBL
      A8KAE4
      Related
      ENSP00000431710.1, ENST00000525975.5
      Conserved Domains (2) summary
      smart00220
      Location:197 → 525
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14229
      Location:196 → 525
      STKc_HIPK3; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 3

    4. NM_005734.5 → NP_005725.3  homeodomain-interacting protein kinase 3 isoform 1

      See identical proteins and their annotated locations for NP_005725.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AF004849, AL122015, BX117467, DR000092, HY053621, Y09306
      Consensus CDS
      CCDS7884.1
      UniProtKB/Swiss-Prot
      O14632, Q2PBG4, Q2PBG5, Q92632, Q9H422, Q9HAS2
      UniProtKB/TrEMBL
      A8KAE4
      Related
      ENSP00000304226.4, ENST00000303296.9
      Conserved Domains (2) summary
      smart00220
      Location:197 → 525
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14229
      Location:196 → 525
      STKc_HIPK3; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 3

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      33256672..33357023
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426223.1 → XP_047282179.1  homeodomain-interacting protein kinase 3 isoform X2

      UniProtKB/TrEMBL
      A8KAE4

    2. XM_047426224.1 → XP_047282180.1  homeodomain-interacting protein kinase 3 isoform X3

      UniProtKB/TrEMBL
      A8KAE4

    3. XM_047426225.1 → XP_047282181.1  homeodomain-interacting protein kinase 3 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      33392109..33492540
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367427.1 → XP_054223402.1  homeodomain-interacting protein kinase 3 isoform X4

      UniProtKB/Swiss-Prot
      O14632, Q2PBG4, Q2PBG5, Q92632, Q9H422, Q9HAS2
      UniProtKB/TrEMBL
      A8KAE4

    2. XM_054367428.1 → XP_054223403.1  homeodomain-interacting protein kinase 3 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H422.1 GenPept UniProtKB/Swiss-Prot:Q9H422

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