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    TMEM132A transmembrane protein 132A [ Homo sapiens (human) ]

    Gene ID: 54972, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TMEM132Aprovided by HGNC
    Official Full Name
    transmembrane protein 132Aprovided by HGNC
    Primary source
    HGNC:HGNC:31092
    See related
    Ensembl:ENSG00000006118 MIM:617363; AllianceGenome:HGNC:31092
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GBP; HSPA5BP1
    Summary
    This gene encodes a protein that is highly similar to the rat Grp78-binding protein (GBP). Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 20.0), endometrium (RPKM 7.5) and 12 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TMEM132A in Genome Data Viewer
    Location:
    11q12.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (60924460..60937159)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (60875611..60888306)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (60691932..60704631)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:60679869-60680867 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:60681866-60682864 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4785 Neighboring gene TMEM109 divergent transcript Neighboring gene uncharacterized LOC124902676 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:60686309-60687508 Neighboring gene transmembrane protein 109 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3377 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3378 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3379 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3380 Neighboring gene solute carrier family 15 member 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4786 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3381 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4787 Neighboring gene CD6 molecule Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4788 Neighboring gene RNA, U6 small nuclear 933, pseudogene Neighboring gene tRNA-Ala (TGC) 10-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Physiological regulation of [beta]-catenin stability by Tcf3 and CK1epsilon. Lee E, et al. J Cell Biol, 2001 Sep 3. PMID 11524435, Free PMC Article
    2. GRP78-binding protein regulates cAMP-induced glial fibrillary acidic protein expression in rat C6 glioblastoma cells. Oh-hashi K, et al. FEBS Lett, 2006 Jul 10. PMID 16806201
    3. TMEM132: an ancient architecture of cohesin and immunoglobulin domains define a new family of neural adhesion molecules. Sanchez-Pulido L, et al. Bioinformatics, 2018 Mar 1. PMID 29088312, Free PMC Article
    4. Cloning and characterization of a novel GRP78-binding protein in the rat brain. Oh-hashi K, et al. J Biol Chem, 2003 Mar 21. PMID 12514190
    5. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2000 Aug 31. PMID 10997877

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. describes characterization of the rat protein
      Title: Cloning and characterization of a novel GRP78-binding protein in the rat brain.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of transmembrane protein 132A (TMEM132A; HSPA5BP1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20539, MGC138669, DKFZp547E212

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of Wnt protein secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 132A
    Names
    GRP78-binding protein
    HSPA5-binding protein 1
    glucose-regulated protein, 78kDa
    heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) binding protein 1
    heat shock 70kDa protein 5 binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017870.4 → NP_060340.2  transmembrane protein 132A isoform a precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AK000546, AK023577, AL359557, AP003721, BC028106, BC032059
      Consensus CDS
      CCDS7997.1
      UniProtKB/Swiss-Prot
      Q24JP5
      Related
      ENSP00000005286.4, ENST00000005286.8
      Conserved Domains (3) summary
      pfam15705
      Location:50 → 171
      TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
      pfam15706
      Location:837 → 904
      TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
      pfam16070
      Location:408 → 750
      TMEM132; Transmembrane protein family 132

    2. NM_178031.3 → NP_821174.1  transmembrane protein 132A isoform b precursor

      See identical proteins and their annotated locations for NP_821174.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses a different in-frame splice site in the coding region, compared to variant 1. The resulting isoform (b) is shorter than isoform a.
      Source sequence(s)
      AK000546, AL359557, AP003721, BC028106
      Consensus CDS
      CCDS44618.1
      UniProtKB/Swiss-Prot
      Q24JP5, Q69YU7, Q86VZ8, Q86W97, Q9H8K3, Q9HCI9, Q9NWY0
      Related
      ENSP00000405823.2, ENST00000453848.7
      Conserved Domains (3) summary
      pfam15705
      Location:48 → 170
      TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
      pfam15706
      Location:836 → 901
      TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
      pfam16070
      Location:407 → 749
      TMEM132; Transmembrane protein family 132

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      60924460..60937159
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017017951.3 → XP_016873440.1  transmembrane protein 132A isoform X1

    2. XM_017017952.3 → XP_016873441.1  transmembrane protein 132A isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      60875611..60888306
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369218.1 → XP_054225193.1  transmembrane protein 132A isoform X1

    2. XM_054369219.1 → XP_054225194.1  transmembrane protein 132A isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24JP5.1 GenPept UniProtKB/Swiss-Prot:Q24JP5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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