U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CREBL2 cAMP responsive element binding protein like 2 [ Homo sapiens (human) ]

    Gene ID: 1389, updated on 9-Dec-2024

    Summary

    Official Symbol
    CREBL2provided by HGNC
    Official Full Name
    cAMP responsive element binding protein like 2provided by HGNC
    Primary source
    HGNC:HGNC:2350
    See related
    Ensembl:ENSG00000111269 MIM:603476; AllianceGenome:HGNC:2350
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in adrenal (RPKM 84.6), thyroid (RPKM 31.5) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CREBL2 in Genome Data Viewer
    Location:
    12p13.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (12611876..12645108)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (12481031..12514259)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (12764810..12798042)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984486 Neighboring gene ribosomal protein L19 pseudogene 17 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6014 Neighboring gene NANOG hESC enhancer GRCh37_chr12:12737991-12738492 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:12749546-12749780 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:12753351-12754550 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:12761265-12761483 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:12764179-12764930 Neighboring gene ribosomal protein L21 pseudogene 136 Neighboring gene Sharpr-MPRA regulatory region 2795 Neighboring gene uncharacterized LOC124902880 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:12796246-12797445 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6017 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6018 Neighboring gene G protein-coupled receptor 19 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:12829332-12830160 Neighboring gene MPRA-validated peak1575 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6019 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6020 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6021 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6022 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6023 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6024 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6025 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6026 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6027 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:12870680-12870868 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6028 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6029 Neighboring gene cyclin dependent kinase inhibitor 1B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Phenotypes

    EBI GWAS Catalog

    Description
    Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC117311, MGC138362

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of D-glucose import ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of lipid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of peptidyl-serine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    cAMP-responsive element-binding protein-like 2
    Names
    MHBs-binding protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310.4NP_001301.1  cAMP-responsive element-binding protein-like 2

      See identical proteins and their annotated locations for NP_001301.1

      Status: REVIEWED

      Source sequence(s)
      AC008115, AI375846, BC106052, BY795169
      Consensus CDS
      CCDS8651.1
      UniProtKB/Swiss-Prot
      B5BUM5, O60519
      Related
      ENSP00000228865.2, ENST00000228865.3
      Conserved Domains (1) summary
      cd14709
      Location:2580
      bZIP_CREBL2; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein-like 2 (CREBL2): a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      12611876..12645108
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      12481031..12514259
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)