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    GPR19 G protein-coupled receptor 19 [ Homo sapiens (human) ]

    Gene ID: 2842, updated on 3-Dec-2024

    Summary

    Official Symbol
    GPR19provided by HGNC
    Official Full Name
    G protein-coupled receptor 19provided by HGNC
    Primary source
    HGNC:HGNC:4473
    See related
    Ensembl:ENSG00000183150 MIM:602927; AllianceGenome:HGNC:4473
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in cilium. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GPR19 in Genome Data Viewer
    Location:
    12p13.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (12660890..12717246, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (12533185..12589333, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (12813824..12849117, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L21 pseudogene 136 Neighboring gene cAMP responsive element binding protein like 2 Neighboring gene Sharpr-MPRA regulatory region 2795 Neighboring gene uncharacterized LOC124902880 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:12796246-12797445 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6017 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6018 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:12829332-12830160 Neighboring gene MPRA-validated peak1575 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6019 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6020 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6021 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6022 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6023 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6024 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6025 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6026 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6027 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:12870680-12870868 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6028 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6029 Neighboring gene uncharacterized LOC105369663 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4262 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4263 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4265 Neighboring gene cyclin dependent kinase inhibitor 1B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    probable G-protein coupled receptor 19
    Names
    GPR-NGA

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006143.3NP_006134.2  probable G-protein coupled receptor 19

      Status: VALIDATED

      Source sequence(s)
      AC008115
      Consensus CDS
      CCDS8652.1
      UniProtKB/Swiss-Prot
      Q15760
      UniProtKB/TrEMBL
      B9EK41
      Related
      ENSP00000498976.1, ENST00000651487.1
      Conserved Domains (1) summary
      cd15008
      Location:67341
      7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      12660890..12717246 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047428742.1XP_047284698.1  probable G-protein coupled receptor 19 isoform X2

      UniProtKB/Swiss-Prot
      Q15760
      UniProtKB/TrEMBL
      B9EK41
    2. XM_011520623.4XP_011518925.1  probable G-protein coupled receptor 19 isoform X1

      See identical proteins and their annotated locations for XP_011518925.1

      UniProtKB/TrEMBL
      B9EK41
      Conserved Domains (2) summary
      pfam00001
      Location:101349
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:91277
      7tm_4; Olfactory receptor
    3. XM_011520624.3XP_011518926.1  probable G-protein coupled receptor 19 isoform X1

      See identical proteins and their annotated locations for XP_011518926.1

      UniProtKB/TrEMBL
      B9EK41
      Conserved Domains (2) summary
      pfam00001
      Location:101349
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:91277
      7tm_4; Olfactory receptor
    4. XM_047428741.1XP_047284697.1  probable G-protein coupled receptor 19 isoform X1

      UniProtKB/TrEMBL
      B9EK41

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      12533185..12589333 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054371850.1XP_054227825.1  probable G-protein coupled receptor 19 isoform X1

      UniProtKB/TrEMBL
      B9EK41
    2. XM_054371851.1XP_054227826.1  probable G-protein coupled receptor 19 isoform X1

      UniProtKB/TrEMBL
      B9EK41
    3. XM_054371849.1XP_054227824.1  probable G-protein coupled receptor 19 isoform X1

      UniProtKB/TrEMBL
      B9EK41
    4. XM_054371852.1XP_054227827.1  probable G-protein coupled receptor 19 isoform X2

      UniProtKB/TrEMBL
      B9EK41, Q6IBH2