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    Sh3glb2 SH3-domain GRB2-like endophilin B2 [ Mus musculus (house mouse) ]

    Gene ID: 227700, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Sh3glb2provided by MGI
    Official Full Name
    SH3-domain GRB2-like endophilin B2provided by MGI
    Primary source
    MGI:MGI:2385131
    See related
    Ensembl:ENSMUSG00000026860 AllianceGenome:MGI:2385131
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SPAS-1
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in membrane organization and postsynaptic neurotransmitter receptor internalization. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in glutamatergic synapse; membrane; and postsynaptic endocytic zone. Is expressed in several structures, including central nervous system; dorsal root ganglion; eye; limb; and skeleton. Orthologous to human SH3GLB2 (SH3 domain containing GRB2 like, endophilin B2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 61.1), frontal lobe adult (RPKM 59.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sh3glb2 in Genome Data Viewer
    Location:
    2 B; 2 21.6 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (30234789..30249380, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30344777..30359358, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7805 Neighboring gene nucleoporin 188 Neighboring gene dolichol kinase Neighboring gene predicted gene, 39780 Neighboring gene mitoguardin 2 Neighboring gene STARR-positive B cell enhancer ABC_E410 Neighboring gene dolichyl pyrophosphate phosphatase 1 Neighboring gene carnitine acetyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Endophilin B2 facilitates endosome maturation in response to growth factor stimulation, autophagy induction, and influenza A virus infection. Serfass JM, et al. J Biol Chem, 2017 Jun 16. PMID 28455444, Free PMC Article
    2. SPAS-1 (stimulator of prostatic adenocarcinoma-specific T cells)/SH3GLB2: A prostate tumor antigen identified by CTLA-4 blockade. Fassò M, et al. Proc Natl Acad Sci U S A, 2008 Mar 4. PMID 18303116, Free PMC Article
    3. Bcl-2 family interaction with the mitochondrial morphogenesis machinery. Cleland MM, et al. Cell Death Differ, 2011 Feb. PMID 20671748, Free PMC Article
    4. Proteomic Analysis of the Spinophilin Interactome in Rodent Striatum Following Psychostimulant Sensitization. Watkins DS, et al. Proteomes, 2018 Dec 17. PMID 30562941, Free PMC Article
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data (including data from studies in knockout mice) suggest that Sh3glb2 regulates trafficking of endocytic vesicles and autophagosomes to late endosomes or lysosomes; despite having an intracellular localization and tissue distribution similar to endophilin B1, endophilin B2 is dispensable for mitochondrial apoptosis.
      Title: Endophilin B2 facilitates endosome maturation in response to growth factor stimulation, autophagy induction, and influenza A virus infection.
    2. the immunodominant SPAS-1 epitope SNC9-H(8) arose from a point mutation in one allele of the gene in transgenic adenocarcinoma of mouse prostate tumor cells
      Title: SPAS-1 (stimulator of prostatic adenocarcinoma-specific T cells)/SH3GLB2: A prostate tumor antigen identified by CTLA-4 blockade.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • KIAA1848

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in postsynaptic neurotransmitter receptor internalization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic endocytic zone ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    endophilin-B2
    Names
    SH3 domain-containing GRB2-like protein B2
    SH3-containing protein SH3GLB2
    stimulator of prostatic adenocarcinoma-specific T-cells-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289709.1 → NP_001276638.1  endophilin-B2 isoform 1

      See identical proteins and their annotated locations for NP_001276638.1

      Status: VALIDATED

      Source sequence(s)
      AK152409, BY317126, BY651947, CB249880, CX216029, EF676083
      Consensus CDS
      CCDS71020.1
      UniProtKB/Swiss-Prot
      Q3TIQ1, Q3U2J4, Q3U824, Q8K140, Q8R3V5, Q91ZI7
      UniProtKB/TrEMBL
      B0LDS3
      Related
      ENSMUSP00000097788.5, ENSMUST00000100215.11
      Conserved Domains (2) summary
      cd07617
      Location:21 → 278
      BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2
      cd11944
      Location:344 → 398
      SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2

    2. NM_001289710.1 → NP_001276639.1  endophilin-B2 isoform 3

      See identical proteins and their annotated locations for NP_001276639.1

      Status: VALIDATED

      Source sequence(s)
      AK152502, BY317126, BY651947, CX216029
      Consensus CDS
      CCDS71018.1
      UniProtKB/TrEMBL
      A2AWI9, B0LDS3
      Related
      ENSMUSP00000109250.4, ENSMUST00000113620.10
      Conserved Domains (2) summary
      cd07617
      Location:21 → 257
      BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2
      cd11944
      Location:318 → 372
      SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2

    3. NM_001346806.2 → NP_001333735.1  endophilin-B2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL954388
      Consensus CDS
      CCDS84504.1
      UniProtKB/TrEMBL
      A2AWI7, B0LDS3
      Related
      ENSMUSP00000109251.4, ENSMUST00000113621.10

    4. NM_001362888.1 → NP_001349817.1  endophilin-B2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL954388
      UniProtKB/TrEMBL
      B0LDS3
      Conserved Domains (2) summary
      cd07617
      Location:21 → 249
      BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2
      cd11944
      Location:310 → 364
      SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2

    5. NM_139302.2 → NP_647463.1  endophilin-B2 isoform 2

      See identical proteins and their annotated locations for NP_647463.1

      Status: VALIDATED

      Source sequence(s)
      AK152409, BY317126, BY651947, CX216029, EF676083
      Consensus CDS
      CCDS15879.1
      UniProtKB/TrEMBL
      B0LDS3
      Related
      ENSMUSP00000028214.9, ENSMUST00000028214.15
      Conserved Domains (2) summary
      cd07617
      Location:21 → 278
      BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2
      cd11944
      Location:339 → 393
      SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2

    RNA

    1. NR_156413.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL954388

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      30234789..30249380 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160832.1 → XP_036016725.1  endophilin-B2 isoform X8

      Conserved Domains (2) summary
      cd11944
      Location:247 → 301
      SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
      cl12013
      Location:1 → 181
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. XM_036160841.1 → XP_036016734.1  endophilin-B2 isoform X11

      Conserved Domains (1) summary
      cl12013
      Location:1 → 181
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    3. XM_006497939.2 → XP_006498002.1  endophilin-B2 isoform X3

      UniProtKB/TrEMBL
      B0LDS3
      Related
      ENSMUSP00000131545.3, ENSMUST00000163668.3
      Conserved Domains (2) summary
      cd07617
      Location:21 → 257
      BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2
      cd11944
      Location:323 → 377
      SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2

    4. XM_030249870.1 → XP_030105730.1  endophilin-B2 isoform X6

      Conserved Domains (1) summary
      cd07617
      Location:21 → 278
      BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2

    5. XM_006497938.2 → XP_006498001.1  endophilin-B2 isoform X2

      UniProtKB/TrEMBL
      B0LDS3
      Conserved Domains (2) summary
      cd07617
      Location:21 → 261
      BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2
      cd11944
      Location:327 → 381
      SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2

    6. XM_006497937.2 → XP_006498000.1  endophilin-B2 isoform X1

      UniProtKB/TrEMBL
      B0LDS3
      Conserved Domains (2) summary
      cd07617
      Location:21 → 282
      BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2
      cd11944
      Location:343 → 397
      SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2

    7. XM_011239078.2 → XP_011237380.1  endophilin-B2 isoform X5

      Conserved Domains (1) summary
      cd07617
      Location:21 → 282
      BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2

    8. XM_011239077.2 → XP_011237379.1  endophilin-B2 isoform X4

      Conserved Domains (1) summary
      cd07617
      Location:21 → 282
      BAR_Endophilin_B2; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B2

    9. XM_006497941.5 → XP_006498004.1  endophilin-B2 isoform X7

      See identical proteins and their annotated locations for XP_006498004.1

      Conserved Domains (2) summary
      cd11944
      Location:251 → 305
      SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
      cl12013
      Location:1 → 185
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    10. XM_030249882.1 → XP_030105742.1  endophilin-B2 isoform X10

      Conserved Domains (2) summary
      cd11944
      Location:226 → 280
      SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
      cl12013
      Location:1 → 160
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    11. XM_030249878.1 → XP_030105738.1  endophilin-B2 isoform X9

      Conserved Domains (2) summary
      cd11944
      Location:242 → 296
      SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
      cl12013
      Location:1 → 181
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    12. XM_006497942.4 → XP_006498005.1  endophilin-B2 isoform X7

      See identical proteins and their annotated locations for XP_006498005.1

      Conserved Domains (2) summary
      cd11944
      Location:251 → 305
      SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
      cl12013
      Location:1 → 185
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    13. XM_036160844.1 → XP_036016737.1  endophilin-B2 isoform X13

      Conserved Domains (2) summary
      cd11944
      Location:159 → 213
      SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
      cl12013
      Location:36 → 98
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    14. XM_036160842.1 → XP_036016735.1  endophilin-B2 isoform X12

      Conserved Domains (2) summary
      cd11944
      Location:164 → 218
      SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
      cl12013
      Location:36 → 98
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    15. XM_030249884.1 → XP_030105744.1  endophilin-B2 isoform X12

      Conserved Domains (2) summary
      cd11944
      Location:164 → 218
      SH3_Endophilin_B2; Src homology 3 domain of Endophilin-B2
      cl12013
      Location:36 → 98
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RNA

    1. XR_004939601.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R3V5.2 GenPept UniProtKB/Swiss-Prot:Q8R3V5

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