PCNA1 proliferating cellular nuclear antigen 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: PCNA1
Official Full Name: proliferating cellular nuclear antigen 1
Primary source: TAIR:AT1G07370
Locus tag: AT1G07370
See related: Araport:AT1G07370
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATPCNA1; F22G5.29; F22G5_29; PROLIFERATING CELLULAR NUCLEAR ANTIGEN; proliferating cellular nuclear antigen 1; PROLIFERATING CELLULAR NUCLEAR ANTIGEN 1
Summary: Encodes putative proliferating cell nuclear antigen involved in cell cycle regulation. May be sumoylated.
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Genomic context

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See PCNA1 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 4

Sequence:: Chromosome: 1; NC_003070.9 (2263037..2264553)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Arabidopsis PCNA1 and PCNA2 differ in their efficiency for ubiquitination and sumoylation, leading to their differential responses to DNA damage in yeast cells.
Title: Similarities and differences between Arabidopsis PCNA1 and PCNA2 in complementing the yeast DNA damage tolerance defect.
PCNA1 and PCNA2 may cooperate in planta by forming homo- and heterotrimeric rings.
Title: Arabidopsis thaliana: proliferating cell nuclear antigen 1 and 2 possibly form homo- and hetero-trimeric complexes in the plant cell.
Ubiquitin-conjugating enzymes and RAD5a proteins are involved in the ubiquitination of plant PCNA at lysine 164.
Title: RAD5a ubiquitin ligase is involved in ubiquitination of Arabidopsis thaliana proliferating cell nuclear antigen.
These results clearly show that plant PCNA is post-translationally modified in bacteria and may be sumoylated in a plant cell at various sites.
Title: Arabidopsis thaliana proliferating cell nuclear antigen has several potential sumoylation sites.
atomic resolution crystal structures of the PCNA1 and PCNA2 complexed with the C-terminal segment of human p21; structures demonstrated that PCNA1 & 2 adopt identical architectures
Title: Crystal structures of the Arabidopsis thaliana proliferating cell nuclear antigen 1 and 2 proteins complexed with the human p21 C-terminal segment.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_100611.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA polymerase processivity factor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of DNA replication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytosol	HDA more info	PubMed
NOT located_in cytosol	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in nucleolus	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: proliferating cellular nuclear antigen 1

NP_172217.1

proliferating cellular nuclear antigen 1 (PCNA1); CONTAINS InterPro DOMAIN/s: Proliferating cell nuclear antigen, PCNA (InterPro:IPR000730), Proliferating cell nuclear antigen, PCNA, C-terminal (InterPro:IPR022649), Proliferating cell nuclear antigen, PCNA, conserved site (InterPro:IPR022659), Proliferating cell nuclear antigen, PCNA, N-terminal (InterPro:IPR022648); BEST Arabidopsis thaliana protein match is: proliferating cell nuclear antigen 2 (TAIR:AT2G29570.1); Has 1857 Blast hits to 1845 proteins in 456 species: Archae - 391; Bacteria - 0; Metazoa - 315; Fungi - 169; Plants - 159; Viruses - 71; Other Eukaryotes - 752 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

2263037..2264553

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_100611.4 → NP_172217.1 proliferating cellular nuclear antigen 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_172217.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A7UIK5, Q9LNV6, Q9M7Q7

UniProtKB/TrEMBL

A0A178W9N0, A0A5S9T434, A0A6B7JDQ1

Conserved Domains (1) summary

PLN00057
Location:1 → 263

PLN00057; proliferating cell nuclear antigen; Provisional