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    Enox1 ecto-NOX disulfide-thiol exchanger 1 [ Mus musculus (house mouse) ]

    Gene ID: 239188, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Enox1provided by MGI
    Official Full Name
    ecto-NOX disulfide-thiol exchanger 1provided by MGI
    Primary source
    MGI:MGI:2444896
    See related
    Ensembl:ENSMUSG00000022012 AllianceGenome:MGI:2444896
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B230207J08; D230005D02Rik
    Summary
    Predicted to enable NADH dehydrogenase activity and protein disulfide isomerase activity. Predicted to be involved in ultradian rhythm. Predicted to be located in external side of plasma membrane and extracellular region. Predicted to be active in plasma membrane. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; eye; and genitourinary system. Orthologous to human ENOX1 (ecto-NOX disulfide-thiol exchanger 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in CNS E18 (RPKM 4.8), CNS E14 (RPKM 4.6) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Enox1 in Genome Data Viewer
    Location:
    14 D3; 14 40.63 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (77393790..77959203)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (77156248..77721763)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr14:77411648-77411949 Neighboring gene STARR-seq mESC enhancer starr_37202 Neighboring gene STARR-seq mESC enhancer starr_37203 Neighboring gene STARR-positive B cell enhancer ABC_E5459 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_37204 Neighboring gene coiled-coil domain containing 122 Neighboring gene laccase domain containing 1 Neighboring gene STARR-positive B cell enhancer mm9_chr14:77541449-77541750 Neighboring gene STARR-seq mESC enhancer starr_37206 Neighboring gene STARR-seq mESC enhancer starr_37207 Neighboring gene STARR-seq mESC enhancer starr_37208 Neighboring gene ribosomal protein L23A pseudogene Neighboring gene predicted gene, 41217 Neighboring gene STARR-seq mESC enhancer starr_37209 Neighboring gene predicted gene 6994 Neighboring gene predicted gene, 23823 Neighboring gene STARR-seq mESC enhancer starr_37212 Neighboring gene predicted gene, 52115 Neighboring gene STARR-seq mESC enhancer starr_37213 Neighboring gene STARR-seq mESC enhancer starr_37215 Neighboring gene predicted gene, 30467 Neighboring gene predicted gene 1587

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Targeting Enox1 in tumor stroma increases the efficacy of fractionated radiotherapy. Smith CA, et al. Oncotarget, 2016 Nov 22. PMID 27788492, Free PMC Article
    2. Response to lithium of a cell surface ECTO-NOX protein with time-keeping characteristics. Kromkowski J, et al. Neurosci Lett, 2008 Jun 13. PMID 18462883
    3. NANOG initiates epiblast fate through the coordination of pluripotency genes expression. Allègre N, et al. Nat Commun, 2022 Jun 21. PMID 35729116, Free PMC Article
    4. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article
    5. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NADH dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NADH dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADH dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein disulfide isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein disulfide isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein disulfide isomerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in ultradian rhythm IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ecto-NOX disulfide-thiol exchanger 1
    Names
    cNOX
    constitutive Ecto-NOX

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253759.1 → NP_001240688.1  ecto-NOX disulfide-thiol exchanger 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK051821, AK082388, BC052062
      Consensus CDS
      CCDS88717.1
      UniProtKB/Swiss-Prot
      Q8BHR2
      Related
      ENSMUSP00000154512.2, ENSMUST00000227662.2
      Conserved Domains (2) summary
      cd12228
      Location:136 → 219
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
      TIGR02168
      Location:307 → 601
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. NM_172813.3 → NP_766401.1  ecto-NOX disulfide-thiol exchanger 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AK051821, AK082388, BC052062
      Consensus CDS
      CCDS27290.1
      UniProtKB/Swiss-Prot
      Q80WS5, Q8BHR2
      Related
      ENSMUSP00000022589.8, ENSMUST00000022589.9
      Conserved Domains (2) summary
      TIGR02168
      Location:291 → 582
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd12228
      Location:136 → 219
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      77393790..77959203
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247809.2 → XP_030103669.1  ecto-NOX disulfide-thiol exchanger 1 isoform X6

      Conserved Domains (2) summary
      COG1196
      Location:448 → 607
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd12228
      Location:135 → 218
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins

    2. XM_011245067.4 → XP_011243369.1  ecto-NOX disulfide-thiol exchanger 1 isoform X4

      Conserved Domains (2) summary
      COG1196
      Location:449 → 608
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd12228
      Location:136 → 219
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins

    3. XM_006519001.5 → XP_006519064.1  ecto-NOX disulfide-thiol exchanger 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8BHR2
      Conserved Domains (2) summary
      cd12228
      Location:136 → 219
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
      TIGR02168
      Location:307 → 601
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    4. XM_030247806.2 → XP_030103666.1  ecto-NOX disulfide-thiol exchanger 1 isoform X3

      UniProtKB/Swiss-Prot
      Q80WS5, Q8BHR2
      Conserved Domains (2) summary
      TIGR02168
      Location:291 → 582
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd12228
      Location:136 → 219
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins

    5. XM_030247812.2 → XP_030103672.1  ecto-NOX disulfide-thiol exchanger 1 isoform X7

      Conserved Domains (2) summary
      cd12228
      Location:136 → 219
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
      TIGR02168
      Location:319 → 550
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    6. XM_030247801.2 → XP_030103661.1  ecto-NOX disulfide-thiol exchanger 1 isoform X1

      Conserved Domains (2) summary
      cd12228
      Location:136 → 219
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
      TIGR02168
      Location:307 → 601
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    7. XM_036158592.1 → XP_036014485.1  ecto-NOX disulfide-thiol exchanger 1 isoform X3

      UniProtKB/Swiss-Prot
      Q80WS5, Q8BHR2
      Conserved Domains (2) summary
      TIGR02168
      Location:291 → 582
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd12228
      Location:136 → 219
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins

    8. XM_036158596.1 → XP_036014489.1  ecto-NOX disulfide-thiol exchanger 1 isoform X10

      Conserved Domains (2) summary
      COG1196
      Location:289 → 514
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd12228
      Location:136 → 219
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins

    9. XM_030247804.2 → XP_030103664.1  ecto-NOX disulfide-thiol exchanger 1 isoform X2

      Conserved Domains (2) summary
      cd12228
      Location:135 → 218
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
      TIGR02168
      Location:306 → 600
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    10. XM_030247808.2 → XP_030103668.1  ecto-NOX disulfide-thiol exchanger 1 isoform X5

      Conserved Domains (2) summary
      TIGR02168
      Location:290 → 581
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd12228
      Location:135 → 218
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins

    11. XM_030247813.2 → XP_030103673.1  ecto-NOX disulfide-thiol exchanger 1 isoform X8

      Conserved Domains (2) summary
      cd12228
      Location:135 → 218
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
      TIGR02168
      Location:318 → 549
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    12. XM_030247800.2 → XP_030103660.1  ecto-NOX disulfide-thiol exchanger 1 isoform X1

      Conserved Domains (2) summary
      cd12228
      Location:136 → 219
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
      TIGR02168
      Location:307 → 601
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    13. XM_030247803.2 → XP_030103663.1  ecto-NOX disulfide-thiol exchanger 1 isoform X1

      Conserved Domains (2) summary
      cd12228
      Location:136 → 219
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
      TIGR02168
      Location:307 → 601
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    14. XM_006519000.5 → XP_006519063.1  ecto-NOX disulfide-thiol exchanger 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8BHR2
      Conserved Domains (2) summary
      cd12228
      Location:136 → 219
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
      TIGR02168
      Location:307 → 601
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    15. XM_017316018.3 → XP_017171507.1  ecto-NOX disulfide-thiol exchanger 1 isoform X3

      UniProtKB/Swiss-Prot
      Q80WS5, Q8BHR2
      Conserved Domains (2) summary
      TIGR02168
      Location:291 → 582
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd12228
      Location:136 → 219
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins

    16. XM_030247811.2 → XP_030103671.1  ecto-NOX disulfide-thiol exchanger 1 isoform X7

      Conserved Domains (2) summary
      cd12228
      Location:136 → 219
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
      TIGR02168
      Location:319 → 550
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    17. XM_006519006.5 → XP_006519069.1  ecto-NOX disulfide-thiol exchanger 1 isoform X2

      Conserved Domains (2) summary
      cd12228
      Location:135 → 218
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
      TIGR02168
      Location:306 → 600
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    18. XM_030247802.2 → XP_030103662.1  ecto-NOX disulfide-thiol exchanger 1 isoform X1

      Conserved Domains (2) summary
      cd12228
      Location:136 → 219
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
      TIGR02168
      Location:307 → 601
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    19. XM_036158593.1 → XP_036014486.1  ecto-NOX disulfide-thiol exchanger 1 isoform X5

      Conserved Domains (2) summary
      TIGR02168
      Location:290 → 581
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd12228
      Location:135 → 218
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins

    20. XM_011245064.4 → XP_011243366.1  ecto-NOX disulfide-thiol exchanger 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8BHR2
      Conserved Domains (2) summary
      cd12228
      Location:136 → 219
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
      TIGR02168
      Location:307 → 601
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    21. XM_006518999.5 → XP_006519062.1  ecto-NOX disulfide-thiol exchanger 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8BHR2
      Conserved Domains (2) summary
      cd12228
      Location:136 → 219
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
      TIGR02168
      Location:307 → 601
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    22. XM_011245066.4 → XP_011243368.1  ecto-NOX disulfide-thiol exchanger 1 isoform X3

      UniProtKB/Swiss-Prot
      Q80WS5, Q8BHR2
      Conserved Domains (2) summary
      TIGR02168
      Location:291 → 582
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd12228
      Location:136 → 219
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins

    23. XM_030247810.2 → XP_030103670.1  ecto-NOX disulfide-thiol exchanger 1 isoform X7

      Conserved Domains (2) summary
      cd12228
      Location:136 → 219
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
      TIGR02168
      Location:319 → 550
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    24. XM_036158594.1 → XP_036014487.1  ecto-NOX disulfide-thiol exchanger 1 isoform X9

      Conserved Domains (2) summary
      pfam05483
      Location:263 → 492
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      cd12228
      Location:136 → 219
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins

    25. XM_036158595.1 → XP_036014488.1  ecto-NOX disulfide-thiol exchanger 1 isoform X10

      Conserved Domains (2) summary
      COG1196
      Location:289 → 514
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd12228
      Location:136 → 219
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins

    26. XM_006519005.5 → XP_006519068.1  ecto-NOX disulfide-thiol exchanger 1 isoform X2

      Conserved Domains (2) summary
      cd12228
      Location:135 → 218
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
      TIGR02168
      Location:306 → 600
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    27. XM_030247807.2 → XP_030103667.1  ecto-NOX disulfide-thiol exchanger 1 isoform X5

      Conserved Domains (2) summary
      TIGR02168
      Location:290 → 581
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd12228
      Location:135 → 218
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins

    28. XM_011245063.4 → XP_011243365.1  ecto-NOX disulfide-thiol exchanger 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8BHR2
      Conserved Domains (2) summary
      cd12228
      Location:136 → 219
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins
      TIGR02168
      Location:307 → 601
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RNA

    1. XR_383180.4 RNA Sequence

    2. XR_003950854.2 RNA Sequence

    3. XR_004938398.1 RNA Sequence

    4. XR_003950851.2 RNA Sequence

    5. XR_004938397.1 RNA Sequence

    6. XR_003950849.2 RNA Sequence

    7. XR_383179.4 RNA Sequence

    8. XR_004938399.1 RNA Sequence

    9. XR_003950850.2 RNA Sequence

    10. XR_004938396.1 RNA Sequence

    11. XR_001781120.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BHR2.1 GenPept UniProtKB/Swiss-Prot:Q8BHR2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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