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    SRSF3 serine and arginine rich splicing factor 3 [ Homo sapiens (human) ]

    Gene ID: 6428, updated on 29-Oct-2024

    Summary

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    Official Symbol
    SRSF3provided by HGNC
    Official Full Name
    serine and arginine rich splicing factor 3provided by HGNC
    Primary source
    HGNC:HGNC:10785
    See related
    Ensembl:ENSG00000112081 MIM:603364; AllianceGenome:HGNC:10785
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SFRS3; SRp20
    Summary
    The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other non-coding, have been found for this gene. [provided by RefSeq, Sep 2010]
    Expression
    Ubiquitous expression in bone marrow (RPKM 107.3), lymph node (RPKM 60.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SRSF3 in Genome Data Viewer
    Location:
    6p21.31-p21.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (36594362..36605600)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (36415006..36426242)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (36562139..36573377)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901558 Neighboring gene serine/threonine kinase 38 Neighboring gene RNA, 7SL, cytoplasmic 748, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:36514791-36515314 Neighboring gene MPRA-validated peak5783 silencer Neighboring gene MPRA-validated peak5784 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:36544382-36545325 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24430 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:36561915-36562596 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:36564442-36564942 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:36564943-36565443 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:36567225-36567726 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:36567727-36568226 Neighboring gene MPRA-validated peak5786 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24432 Neighboring gene microRNA 3925 Neighboring gene MPRA-validated peak5787 silencer Neighboring gene uncharacterized LOC105375038 Neighboring gene RNA, U1 small nuclear 88, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Inclusion of hnRNP L Alternative Exon 7 Is Associated with Good Prognosis and Inhibited by Oncogene SRSF3 in Head and Neck Squamous Cell Carcinoma. Xu L, et al. Biomed Res Int, 2019. PMID 31828152, Free PMC Article
    2. Serine/arginine-rich splicing factor 3 (SRSF3) regulates homologous recombination-mediated DNA repair. He X, et al. Mol Cancer, 2015 Aug 19. PMID 26282282, Free PMC Article
    3. A genome landscape of SRSF3-regulated splicing events and gene expression in human osteosarcoma U2OS cells. Ajiro M, et al. Nucleic Acids Res, 2016 Feb 29. PMID 26704980, Free PMC Article
    4. Splicing machinery dysregulation drives glioblastoma development/aggressiveness: oncogenic role of SRSF3. Fuentes-Fayos AC, et al. Brain, 2020 Dec 5. PMID 33141183, Free PMC Article
    5. Knockdown of splicing factor SRp20 causes apoptosis in ovarian cancer cells and its expression is associated with malignancy of epithelial ovarian cancer. He X, et al. Oncogene, 2011 Jan 20. PMID 20856201, Free PMC Article

    See all (294) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SRSF3 suppresses RCC tumorigenesis and progression via regulating SP4 alternative splicing.
      Title: SRSF3 suppresses RCC tumorigenesis and progression via regulating SP4 alternative splicing.
    2. Restoring SRSF3 in Kupffer cells attenuates obesity-related insulin resistance.
      Title: Restoring SRSF3 in Kupffer cells attenuates obesity-related insulin resistance.
    3. Factors affecting the expression and stability of full-length and truncated SRSF3 proteins in human cancer cells.
      Title: Factors affecting the expression and stability of full-length and truncated SRSF3 proteins in human cancer cells.
    4. Intronic miR-6741-3p targets the oncogene SRSF3: Implications for oral squamous cell carcinoma pathogenesis.
      Title: Intronic miR-6741-3p targets the oncogene SRSF3: Implications for oral squamous cell carcinoma pathogenesis.
    5. Circular RNA hsa_circ_0050386 suppresses non-small cell lung cancer progression via regulating the SRSF3/FN1 axis.
      Title: Circular RNA hsa_circ_0050386 suppresses non-small cell lung cancer progression via regulating the SRSF3/FN1 axis.
    6. An anti-PD-1 antisense oligonucleotide promotes the expression of soluble PD-1 by blocking the interaction between SRSF3 and an exonic splicing enhancer of PD-1 exon 3.
      Title: An anti-PD-1 antisense oligonucleotide promotes the expression of soluble PD-1 by blocking the interaction between SRSF3 and an exonic splicing enhancer of PD-1 exon 3.
    7. Homeobox B9 Promotes Colon Cancer Progression by Targeting SRSF3.
      Title: Homeobox B9 Promotes Colon Cancer Progression by Targeting SRSF3.
    8. SRSF3/AMOTL1 splicing axis promotes the tumorigenesis of nasopharyngeal carcinoma through regulating the nucleus translocation of YAP1.
      Title: SRSF3/AMOTL1 splicing axis promotes the tumorigenesis of nasopharyngeal carcinoma through regulating the nucleus translocation of YAP1.
    9. Genetic compensation response could exist in colorectal cancer: UPF3A upregulates the oncogenic homologue gene SRSF3 expression corresponding to SRSF6 to promote colorectal cancer metastasis.
      Title: Genetic compensation response could exist in colorectal cancer: UPF3A upregulates the oncogenic homologue gene SRSF3 expression corresponding to SRSF6 to promote colorectal cancer metastasis.
    10. Splicing factor SRSF3 promotes the progression of cervical cancer through regulating DDX5.
      Title: Splicing factor SRSF3 promotes the progression of cervical cancer through regulating DDX5.
    Submit: New GeneRIF Correction See all GeneRIFs (90)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat SRSF3 (serine/arginine-rich splicing factor 3) inhibits HIV-1 Tat-mediated transactivation activity in HEK293 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phospholipase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables pre-mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables primary miRNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-RNA sequence-specific adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to leukemia inhibitory factor IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA export from nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in primary miRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    serine/arginine-rich splicing factor 3
    Names
    epididymis secretory sperm binding protein
    pre-mRNA splicing factor SRp20
    pre-mRNA-splicing factor SRP20
    splicing factor, arginine/serine-rich 3
    splicing factor, arginine/serine-rich, 20-kD

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003017.5 → NP_003008.1  serine/arginine-rich splicing factor 3

      See identical proteins and their annotated locations for NP_003008.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the protein-coding variant.
      Source sequence(s)
      Z85986
      Consensus CDS
      CCDS4823.1
      UniProtKB/Swiss-Prot
      B4E241, O08831, P23152, P84103, Q5R3K0
      UniProtKB/TrEMBL
      B2R6F3
      Related
      ENSP00000362820.5, ENST00000373715.11
      Conserved Domains (1) summary
      cd12645
      Location:6 → 86
      RRM_SRSF3; RNA recognition motif (RRM) found in vertebrate serine/arginine-rich splicing factor 3 (SRSF3)

    RNA

    1. NR_036610.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an additional exon in the 3' UTR compared to variant 1, making this transcript a candidate for nonsense-mediated mRNA decay (NMD). Therefore, this transcript is not thought to be protein-coding.
      Source sequence(s)
      AF107405, BM833102, DC398250, Z85986

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      36594362..36605600
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      36415006..36426242
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P84103.1 GenPept UniProtKB/Swiss-Prot:P84103

    Gene LinkOut

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