TEAD4 TEA domain transcription factor 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TEAD4provided by HGNC
Official Full Name: TEA domain transcription factor 4provided by HGNC
Primary source: HGNC:HGNC:11717
See related: Ensembl:ENSG00000197905 MIM:601714; AllianceGenome:HGNC:11717
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TEF3; RTEF1; TEF-3; EFTR-2; TEFR-1; TCF13L1; hRTEF-1B
Summary: This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in thyroid (RPKM 4.8), placenta (RPKM 4.3) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12p13.33

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (2959397..3040676)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (2965518..3046795)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (3068563..3149842)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reappraisal of psoriasis pathogenesis: the role of TEAD4 expression in keratinocytes.
Title: Reappraisal of psoriasis pathogenesis: the role of TEAD4 expression in keratinocytes.
KAT6A/YAP/TEAD4 pathway modulates osteoclastogenesis by regulating the RANKL/OPG ratio on the compression side during orthodontic tooth movement.
Title: KAT6A/YAP/TEAD4 pathway modulates osteoclastogenesis by regulating the RANKL/OPG ratio on the compression side during orthodontic tooth movement.
RBM8A, a new target of TEAD4, promotes breast cancer progression by regulating IGF1R and IRS-2.
Title: RBM8A, a new target of TEAD4, promotes breast cancer progression by regulating IGF1R and IRS-2.
TEAD4 Activates PCSK9 to Promote Stomach Adenocarcinoma Cell Stemness through Fatty Acid Metabolism.
Title: TEAD4 Activates PCSK9 to Promote Stomach Adenocarcinoma Cell Stemness through Fatty Acid Metabolism.
Tead4 and Tfap2c generate bipotency and a bistable switch in totipotent embryos to promote robust lineage diversification.
Title: Tead4 and Tfap2c generate bipotency and a bistable switch in totipotent embryos to promote robust lineage diversification.
The tumor suppressor NF2 modulates TEAD4 stability and activity in Hippo signaling via direct interaction.
Title: The tumor suppressor NF2 modulates TEAD4 stability and activity in Hippo signaling via direct interaction.
Integrative Epigenetic and Molecular Analysis Reveals a Novel Promoter for a New Isoform of the Transcription Factor TEAD4.
Title: Integrative Epigenetic and Molecular Analysis Reveals a Novel Promoter for a New Isoform of the Transcription Factor TEAD4.
VGLL1 cooperates with TEAD4 to control human trophectoderm lineage specification.
Title: VGLL1 cooperates with TEAD4 to control human trophectoderm lineage specification.
TEAD4: A key regulator of tumor metastasis and chemoresistance - Mechanisms and therapeutic implications.
Title: TEAD4: A key regulator of tumor metastasis and chemoresistance - Mechanisms and therapeutic implications.
High TEAD4 Expression is Associated With Aggressive Clear Cell Renal Cell Carcinoma, Regardless of YAP1 Expression.
Title: High TEAD4 Expression is Associated With Aggressive Clear Cell Renal Cell Carcinoma, Regardless of YAP1 Expression.

Submit: New GeneRIF Correction See all GeneRIFs (81)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Clinical, polysomnographic and genome-wide association analyses of narcolepsy with cataplexy: a European Narcolepsy Network study. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH70692 (e-PCR)
- UniSTS:43522

SHGC-79256 (e-PCR)
- UniSTS:102786

Tead4 (e-PCR), detects polymorphism
- UniSTS:144599

Tead4 (e-PCR), detects polymorphism
- UniSTS:548086

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in cell fate specification	IEA Inferred from Electronic Annotation more info
involved_in embryo implantation	IEA Inferred from Electronic Annotation more info
involved_in embryonic organ development	IBA Inferred from Biological aspect of Ancestor more info
involved_in hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in hippo signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in muscle organ development	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of stem cell population maintenance	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in skeletal system development	TAS Traceable Author Statement more info
involved_in trophectodermal cell fate commitment	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromatin	ISA Inferred from Sequence Alignment more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of protein-DNA complex	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transcriptional enhancer factor TEF-3

Names: TEA domain family member 4; related transcription enhancer factor 1B; transcription factor 13-like 1; transcription factor RTEF-1; transcriptional enhancer factor 1-related; transcriptional enhancer factor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029958.1 RefSeqGene

Range

5086..86365

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_003213.4 → NP_003204.2 transcriptional enhancer factor TEF-3 isoform 1

See identical proteins and their annotated locations for NP_003204.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1), and initiates translation from a non-AUG (UUG) codon.

Source sequence(s)

BC015497, DA210894, U63824

Consensus CDS

CCDS31729.1

UniProtKB/Swiss-Prot

H0Y308, Q15561, Q6MZR9, Q8NEV5, Q92883, Q96BK2

UniProtKB/TrEMBL

Q53GI4

Related

ENSP00000352926.3, ENST00000359864.8

Conserved Domains (1) summary

smart00426
Location:38 → 105

TEA; TEA domain
NM_201441.3 → NP_958849.1 transcriptional enhancer factor TEF-3 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1, resulting in an isoform (2) that is missing an internal segment compared to isoform 1. It also initiates translation from a non-AUG (UUG) codon.

Source sequence(s)

AY101179, BM555991, U63824

Consensus CDS

CCDS31730.1

UniProtKB/TrEMBL

A0A0A0MRF3

Related

ENSP00000351184.3, ENST00000358409.7

Conserved Domains (1) summary

smart00426
Location:38 → 105

TEA; TEA domain
NM_201443.3 → NP_958851.1 transcriptional enhancer factor TEF-3 isoform 3

See identical proteins and their annotated locations for NP_958851.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks the exon containing the non-AUG (UUG) translation initiation codon compared to variant 1. It uses an in-frame, downstream AUG, resulting in an isoform (3) with a shorter N-terminus compared to isoform 1.

Source sequence(s)

BX640921, DA886817, U63824

Consensus CDS

CCDS41737.1

UniProtKB/Swiss-Prot

Q15561

Related

ENSP00000380311.2, ENST00000397122.6