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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_023243.1 RefSeqGene
- Range
-
5004..18927
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001256264.2 → NP_001243193.1 protein flightless-1 homolog isoform 2
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) has an alternate 5' exon, which includes the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
- Source sequence(s)
-
AC127537, AK310400, BC025300, BM930929
- Consensus CDS
-
CCDS58521.1
- UniProtKB/TrEMBL
-
B4DIX0
- Related
- ENSP00000463534.1, ENST00000579294.5
- Conserved Domains (9) summary
-
- cd11280
Location:608 → 695
- gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
- cd11288
Location:1042 → 1141
- gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
- cd11290
Location:481 → 593
- gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
- cd11291
Location:1152 → 1251
- gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
- cd11292
Location:712 → 826
- gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
- cd00116
Location:78 → 363
- LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
- sd00031
Location:72 → 94
- LRR_1; leucine-rich repeat [structural motif]
- sd00033
Location:95 → 117
- LRR_RI; leucine-rich repeat [structural motif]
- pfam13855
Location:120 → 175
- LRR_8; Leucine rich repeat
-
NM_001256265.2 → NP_001243194.1 protein flightless-1 homolog isoform 3
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (3) is shorter than isoform 1.
- Source sequence(s)
-
AK295655, BC017030, BM930929, DC341570
- Consensus CDS
-
CCDS58522.1
- UniProtKB/TrEMBL
-
B4DIX0
- Related
- ENSP00000438536.2, ENST00000545457.6
- Conserved Domains (8) summary
-
- cd11280
Location:564 → 651
- gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
- cd11288
Location:998 → 1097
- gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
- cd11290
Location:437 → 549
- gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
- cd11291
Location:1108 → 1207
- gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
- cd11292
Location:668 → 782
- gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
- cd00116
Location:26 → 228
- LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
- sd00033
Location:58 → 80
- LRR_RI; leucine-rich repeat [structural motif]
- pfam13855
Location:169 → 227
- LRR_8; Leucine rich repeat
-
NM_002018.4 → NP_002009.1 protein flightless-1 homolog isoform 1
See identical proteins and their annotated locations for NP_002009.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) encodes the longest isoform (1).
- Source sequence(s)
-
BC025300, BM930929
- Consensus CDS
-
CCDS11192.1
- UniProtKB/Swiss-Prot
- B4DIL0, F5H407, J3QLG3, Q13045
- UniProtKB/TrEMBL
-
B4DIX0
- Related
- ENSP00000324573.4, ENST00000327031.9
- Conserved Domains (9) summary
-
- cd11280
Location:619 → 706
- gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
- cd11288
Location:1053 → 1152
- gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
- cd11290
Location:492 → 604
- gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
- cd11291
Location:1163 → 1262
- gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
- cd11292
Location:723 → 837
- gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
- cd00116
Location:89 → 374
- LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
- sd00031
Location:83 → 105
- LRR_1; leucine-rich repeat [structural motif]
- sd00033
Location:106 → 128
- LRR_RI; leucine-rich repeat [structural motif]
- pfam13855
Location:131 → 186
- LRR_8; Leucine rich repeat
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000017.11 Reference GRCh38.p14 Primary Assembly
- Range
-
18244815..18259022 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_005256558.4 → XP_005256615.1 protein flightless-1 homolog isoform X3
- UniProtKB/TrEMBL
-
B4DIX0
- Conserved Domains (9) summary
-
- cd11280
Location:618 → 705
- gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
- cd11288
Location:1052 → 1151
- gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
- cd11290
Location:491 → 603
- gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
- cd11291
Location:1162 → 1261
- gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
- cd11292
Location:722 → 836
- gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
- cd00116
Location:89 → 374
- LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
- sd00031
Location:83 → 105
- LRR_1; leucine-rich repeat [structural motif]
- sd00033
Location:106 → 128
- LRR_RI; leucine-rich repeat [structural motif]
- pfam13855
Location:131 → 186
- LRR_8; Leucine rich repeat
-
XM_005256556.5 → XP_005256613.1 protein flightless-1 homolog isoform X2
- UniProtKB/TrEMBL
-
B4DIX0
- Conserved Domains (9) summary
-
- cd11280
Location:618 → 705
- gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
- cd11288
Location:1052 → 1151
- gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
- cd11290
Location:491 → 603
- gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
- cd11291
Location:1162 → 1288
- gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
- cd11292
Location:722 → 836
- gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
- cd00116
Location:89 → 374
- LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
- sd00031
Location:83 → 105
- LRR_1; leucine-rich repeat [structural motif]
- sd00033
Location:106 → 128
- LRR_RI; leucine-rich repeat [structural motif]
- pfam13855
Location:131 → 186
- LRR_8; Leucine rich repeat
-
XM_005256555.5 → XP_005256612.1 protein flightless-1 homolog isoform X1
- UniProtKB/TrEMBL
-
B4DIX0
- Conserved Domains (9) summary
-
- cd11280
Location:619 → 706
- gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
- cd11288
Location:1053 → 1152
- gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
- cd11290
Location:492 → 604
- gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
- cd11291
Location:1163 → 1289
- gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
- cd11292
Location:723 → 837
- gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
- cd00116
Location:89 → 374
- LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
- sd00031
Location:83 → 105
- LRR_1; leucine-rich repeat [structural motif]
- sd00033
Location:106 → 128
- LRR_RI; leucine-rich repeat [structural motif]
- pfam13855
Location:131 → 186
- LRR_8; Leucine rich repeat
Reference GRCh38.p14 PATCHES
Genomic
-
NW_017363819.1 Reference GRCh38.p14 PATCHES
- Range
-
5189..19396 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054332091.1 → XP_054188066.1 protein flightless-1 homolog isoform X3
-
XM_054332090.1 → XP_054188065.1 protein flightless-1 homolog isoform X2
-
XM_054332089.1 → XP_054188064.1 protein flightless-1 homolog isoform X1
Alternate T2T-CHM13v2.0
Genomic
-
NC_060941.1 Alternate T2T-CHM13v2.0
- Range
-
18191619..18205827 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054315574.1 → XP_054171549.1 protein flightless-1 homolog isoform X3
-
XM_054315573.1 → XP_054171548.1 protein flightless-1 homolog isoform X2
-
XM_054315572.1 → XP_054171547.1 protein flightless-1 homolog isoform X1