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    EIF4A1 eukaryotic translation initiation factor 4A1 [ Homo sapiens (human) ]

    Gene ID: 1973, updated on 3-Nov-2024

    Summary

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    Official Symbol
    EIF4A1provided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 4A1provided by HGNC
    Primary source
    HGNC:HGNC:3282
    See related
    Ensembl:ENSG00000161960 MIM:602641; AllianceGenome:HGNC:3282
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DDX2A; EIF4A; EIF-4A; eIF4A-I; eIF-4A-I
    Summary
    Enables double-stranded RNA binding activity and translation initiation factor activity. Involved in cytoplasmic translational initiation and positive regulation of transcription by RNA polymerase II. Located in nuclear stress granule; perinuclear region of cytoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in appendix (RPKM 182.3), bone marrow (RPKM 177.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See EIF4A1 in Genome Data Viewer
    Location:
    17p13.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (7572825..7579006)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (7477072..7483254)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7476143..7482324)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene TNFSF12-TNFSF13 readthrough Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7460817-7461610 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11627 Neighboring gene TNF superfamily member 13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11628 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8128 Neighboring gene SENP3-EIF4A1 readthrough (NMD candidate) Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7466006-7466702 Neighboring gene SUMO specific peptidase 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11629 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11630 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11631 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11632 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8129 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8130 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7476397-7477152 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:7477153-7477908 Neighboring gene small nucleolar RNA, H/ACA box 48 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:7481957-7482145 Neighboring gene small nucleolar RNA, C/D box 10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11634 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11635 Neighboring gene small nucleolar RNA, H/ACA box 67 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7485994-7486867 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7486868-7487742 Neighboring gene MPDU1 antisense RNA 1 Neighboring gene CD68 molecule Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7487743-7488615 Neighboring gene mannose-P-dolichol utilization defect 1 Neighboring gene SRY-box transcription factor 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of hippuristanol-resistant mutants reveals eIF4A1 dependencies within mRNA 5' leader regions. Steinberger J, et al. Nucleic Acids Res, 2020 Sep 25. PMID 32766783, Free PMC Article
    2. RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer. Wolfe AL, et al. Nature, 2014 Sep 4. PMID 25079319, Free PMC Article
    3. The malignant phenotype in breast cancer is driven by eIF4A1-mediated changes in the translational landscape. Modelska A, et al. Cell Death Dis, 2015 Jan 22. PMID 25611378, Free PMC Article
    4. Single-molecule kinetics of the eukaryotic initiation factor 4AI upon RNA unwinding. Sun Y, et al. Structure, 2014 Jul 8. PMID 24909782
    5. Decreased expression of EIF4A1 after preoperative brachytherapy predicts better tumor-specific survival in cervical cancer. Liang S, et al. Int J Gynecol Cancer, 2014 Jun. PMID 24844222

    See all (318) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genetic evidence supporting potential causal roles of EIF4 family in breast cancer: a two-sample randomized Mendelian study.
      Title: Genetic evidence supporting potential causal roles of EIF4 family in breast cancer: a two-sample randomized Mendelian study.
    2. mTORC1/S6K1 signaling promotes sustained oncogenic translation through modulating CRL3[IBTK]-mediated ubiquitination of eIF4A1 in cancer cells.
      Title: mTORC1/S6K1 signaling promotes sustained oncogenic translation through modulating CRL3(IBTK)-mediated ubiquitination of eIF4A1 in cancer cells.
    3. eIF4A1-dependent mRNAs employ purine-rich 5'UTR sequences to activate localised eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation.
      Title: eIF4A1-dependent mRNAs employ purine-rich 5'UTR sequences to activate localised eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation.
    4. eIF4A1 Is a Prognostic Marker and Actionable Target in Human Hepatocellular Carcinoma.
      Title: eIF4A1 Is a Prognostic Marker and Actionable Target in Human Hepatocellular Carcinoma.
    5. eIF4A/PDCD4 Pathway, a Factor for Doxorubicin Chemoresistance in a Triple-Negative Breast Cancer Cell Model.
      Title: eIF4A/PDCD4 Pathway, a Factor for Doxorubicin Chemoresistance in a Triple-Negative Breast Cancer Cell Model.
    6. Epigenetic regulation of EIF4A1 through DNA methylation and an oncogenic role of eIF4A1 through BRD2 signaling in prostate cancer.
      Title: Epigenetic regulation of EIF4A1 through DNA methylation and an oncogenic role of eIF4A1 through BRD2 signaling in prostate cancer.
    7. Targeting eIF4A-Dependent Translation of KRAS Signaling Molecules.
      Title: Targeting eIF4A-Dependent Translation of KRAS Signaling Molecules.
    8. High intratumoral expression of eIF4A1 promotes epithelial-to-mesenchymal transition and predicts unfavorable prognosis in gastric cancer.
      Title: High intratumoral expression of eIF4A1 promotes epithelial-to-mesenchymal transition and predicts unfavorable prognosis in gastric cancer.
    9. Identification and characterization of hippuristanol-resistant mutants reveals eIF4A1 dependencies within mRNA 5' leader regions.
      Title: Identification and characterization of hippuristanol-resistant mutants reveals eIF4A1 dependencies within mRNA 5' leader regions.
    10. The mRNA helicase eIF4A1 is involved in unwinding the G4 in the 5'-UTR of CtlP mRNA through its cooperation with ALC1.
      Title: ALC1/eIF4A1-mediated regulation of CtIP mRNA stability controls DNA end resection.
    Submit: New GeneRIF Correction See all GeneRIFs (51)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation initiation factor 4A1 (EIF4A1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation initiation factor 4A1 (EIF4A1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation initiation factor 4A1 (EIF4A1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation initiation factor 4A1 (EIF4A1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding HDA PubMed 
    enables RNA cap binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables helicase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables mRNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation factor activity, RNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic translational initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translational initiation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of eukaryotic translation initiation factor 4F complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 4F complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in membrane HDA PubMed 
    located_in nuclear stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    eukaryotic initiation factor 4A-I
    Names
    ATP-dependent RNA helicase eIF4A-1
    eukaryotic initiation factor 4AI
    eukaryotic translation initiation factor 4A
    NP_001191439.1
    NP_001407.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001204510.2 → NP_001191439.1  eukaryotic initiation factor 4A-I isoform 2

      See identical proteins and their annotated locations for NP_001191439.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site that causes a frameshift in the 3' coding region, compared to variant 1, resulting in an isoform (2) with a distinct and shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AA446856, AC016876, BC006210, BG284868
      Consensus CDS
      CCDS58511.1
      UniProtKB/TrEMBL
      J3KT12
      Related
      ENSP00000463486.1, ENST00000577269.5
      Conserved Domains (1) summary
      cl26939
      Location:20 → 334
      DEXDc; DEAD-like helicases superfamily

    2. NM_001416.4 → NP_001407.1  eukaryotic initiation factor 4A-I isoform 1

      See identical proteins and their annotated locations for NP_001407.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA446856, AC016876, BG284868
      Consensus CDS
      CCDS11113.1
      UniProtKB/Swiss-Prot
      B2R6L8, D3DTP9, J3QLC4, P04765, P60842, Q5U018, Q61516
      UniProtKB/TrEMBL
      A8K088, A8K7F6
      Related
      ENSP00000293831.8, ENST00000293831.13
      Conserved Domains (1) summary
      PTZ00424
      Location:20 → 406
      PTZ00424; helicase 45; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      7572825..7579006
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      7477072..7483254
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P60842.1 GenPept UniProtKB/Swiss-Prot:P60842

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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