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    zbtb16a zinc finger and BTB domain containing 16a [ Danio rerio (zebrafish) ]

    Gene ID: 323269, updated on 2-Nov-2024

    Summary

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    Official Symbol
    zbtb16aprovided by ZNC
    Official Full Name
    zinc finger and BTB domain containing 16aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1989
    See related
    Ensembl:ENSDARG00000007184 AllianceGenome:ZFIN:ZDB-GENE-030131-1989
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ZNF145; zbtb16; zgc:55675; wu:fb93g12; wu:fc07c10
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within positive regulation of type I interferon production and regulation of neurogenesis. Located in nucleus. Is expressed in several structures, including anterior neural keel; anterior neural rod; central nervous system; pleuroperitoneal region; and posterior neural rod. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia. Orthologous to human ZBTB16 (zinc finger and BTB domain containing 16). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See zbtb16a in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (23163987..23307796, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (23123746..23271211, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 28 Neighboring gene uncharacterized LOC137488814 Neighboring gene 5-hydroxytryptamine (serotonin) receptor 3A Neighboring gene uncharacterized LOC137488815 Neighboring gene neural cell adhesion molecule 1a Neighboring gene uncharacterized LOC101885070

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A zebrafish model for pyruvate dehydrogenase deficiency: rescue of neurological dysfunction and embryonic lethality using a ketogenic diet. Taylor MR, et al. Proc Natl Acad Sci U S A, 2004 Mar 30. PMID 15070761, Free PMC Article
    2. Evaluation of Sycp3, Plzf and Cyclin B3 expression and suitability as spermatogonia and spermatocyte markers in zebrafish. Ozaki Y, et al. Gene Expr Patterns, 2011 Jun-Jul. PMID 21402175
    3. Isolation and cytogenetic characterization of zebrafish meiotic prophase I mutants. Saito K, et al. Dev Dyn, 2011 Jul. PMID 21594953
    4. Establishment of novel monoclonal antibodies for identification of type A spermatogonia in teleosts†. Hayashi M, et al. Biol Reprod, 2019 Aug 1. PMID 31077286
    5. Transcriptome-wide subtyping of pediatric and adult T cell acute lymphoblastic leukemia in an international study of 707 cases. Dai YT, et al. Proc Natl Acad Sci U S A, 2022 Apr 12. PMID 35385357, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zbtb16 mediates a switch between Fgf signalling regimes in the developing hindbrain.
      Title: Zbtb16 mediates a switch between Fgf signalling regimes in the developing hindbrain.
    2. the results provide strong evidence that zbtb16a loss of function is associated with a partially penetrant severe cardiac development defect.
      Title: A Rapid Method for Directed Gene Knockout for Screening in G0 Zebrafish.
    3. Although zbtb16a and zbtb16b are not modulated by IFN produced during viral infection, their over-expression increases the level of the early type I IFN response, at a critical phase in the race between the virus and the host response.
      Title: Zebrafish Plzf transcription factors enhance early type I IFN response induced by two non-enveloped RNA viruses.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of type I interferon production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of neurogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 16-A
    Names
    plzfa
    promyelocytic leukemia zinc finger protein-A
    zinc finger and BTB domain containing 16
    zinc finger protein 145 (Kruppel-like, expressed in promyelocytic leukemia)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199635.1 → NP_955929.1  zinc finger and BTB domain-containing protein 16-A

      See identical proteins and their annotated locations for NP_955929.1

      Status: PROVISIONAL

      Source sequence(s)
      BC046887
      UniProtKB/Swiss-Prot
      Q802Y8
      Related
      ENSDARP00000153802.1, ENSDART00000184419.1
      Conserved Domains (6) summary
      smart00225
      Location:35 → 106
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG5048
      Location:445 → 620
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:546 → 566
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:515 → 537
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:25 → 106
      BTB; BTB/POZ domain
      pfam13465
      Location:559 → 582
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      23163987..23307796 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009295291.4 → XP_009293566.1  zinc finger and BTB domain-containing protein 16-A isoform X1

      UniProtKB/TrEMBL
      A0A8M3ATT4, E7FDS7
      Related
      ENSDARP00000024790.8, ENSDART00000007806.9
      Conserved Domains (6) summary
      smart00225
      Location:35 → 106
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG5048
      Location:445 → 619
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:517 → 537
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:515 → 537
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:25 → 106
      BTB; BTB/POZ domain
      pfam13465
      Location:558 → 581
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q802Y8.1 GenPept UniProtKB/Swiss-Prot:Q802Y8

    Gene LinkOut

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