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    ahctf1 AT hook containing transcription factor 1 [ Danio rerio (zebrafish) ]

    Gene ID: 553494, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ahctf1provided by ZNC
    Official Full Name
    AT hook containing transcription factor 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070521-2
    See related
    Ensembl:ENSDARG00000077530 AllianceGenome:ZFIN:ZDB-GENE-070521-2
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fa02e01; wu:fa02e01
    Summary
    Acts upstream of or within several processes, including hepatocyte proliferation; nuclear pore complex assembly; and regulation of hepatocyte apoptotic process. Predicted to be located in nucleus. Is expressed in brain; digestive system; head; immature eye; and pectoral fin. Orthologous to human AHCTF1 (AT-hook containing transcription factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ahctf1 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (12221473..12249963, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (12067407..12095890, complement)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene saccharopine dehydrogenase a, tandem duplicate 1 Neighboring gene kinesin family member 28 Neighboring gene Pim proto-oncogene, serine/threonine kinase, related 175 Neighboring gene serine/threonine-protein kinase pim-2-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Abnormal nuclear pore formation triggers apoptosis in the intestinal epithelium of elys-deficient zebrafish. de Jong-Curtain TA, et al. Gastroenterology, 2009 Mar. PMID 19073184, Free PMC Article
    2. Mutations linked to loss of cell cycle control can render cells responsive to local differentiation cues. Cerveny KL, et al. MicroPubl Biol, 2021. PMID 34723143, Free PMC Article
    3. The zebrafish flotte lotte mutant reveals that the local retinal environment promotes the differentiation of proliferating precursors emerging from their stem cell niche. Cerveny KL, et al. Development, 2010 Jul. PMID 20504962, Free PMC Article
    4. Mutation of the zebrafish nucleoporin elys sensitizes tissue progenitors to replication stress. Davuluri G, et al. PLoS Genet, 2008 Oct. PMID 18974873, Free PMC Article
    5. Montmorillonite clay and humic acid modulate the behavior of copper oxide nanoparticles in aqueous environment and induces developmental defects in zebrafish embryo. Kansara K, et al. Environ Pollut, 2019 Dec. PMID 31600709

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ahctf1 and kras mutations combine to amplify oncogenic stress and restrict liver overgrowth in a zebrafish model of hepatocellular carcinoma.
      Title: ahctf1 and kras mutations combine to amplify oncogenic stress and restrict liver overgrowth in a zebrafish model of hepatocellular carcinoma.
    2. findings show that mutation of the Elys nucleoporin causes widespread apoptosis in the intestine and other tissues of zebrafish flotte lotte (flo) mutants; data indicate a role for Elys in Mcm2-chromatin interactions[elys]
      Title: Mutation of the zebrafish nucleoporin elys sensitizes tissue progenitors to replication stress.
    3. Results suggest that the flo gene product, Elys, is dispensable for maintaining a stem cell-like state, but is important for the transition from proliferation to differentiation.
      Title: The zebrafish flotte lotte mutant reveals that the local retinal environment promotes the differentiation of proliferating precursors emerging from their stem cell niche.
    4. Elys regulates digestive organ formation
      Title: Abnormal nuclear pore formation triggers apoptosis in the intestinal epithelium of elys-deficient zebrafish.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within digestive tract development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hepatocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within nuclear pore complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of hepatocyte apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein ELYS
    Names
    elys
    flo

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      12221473..12249963 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009292870.4 → XP_009291145.1  protein ELYS

      See identical proteins and their annotated locations for XP_009291145.1

      UniProtKB/TrEMBL
      A0A8N7T6T7, X1WE68
      Conserved Domains (2) summary
      pfam13934
      Location:724 → 950
      ELYS; Nuclear pore complex assembly
      pfam16687
      Location:2 → 489
      ELYS-bb; beta-propeller of ELYS nucleoporin

    2. XM_692635.9 → XP_697727.4  protein ELYS

      See identical proteins and their annotated locations for XP_697727.4

      UniProtKB/TrEMBL
      A0A8N7T6T7, X1WE68
      Related
      ENSDARP00000128519.1, ENSDART00000155545.2
      Conserved Domains (2) summary
      pfam13934
      Location:724 → 950
      ELYS; Nuclear pore complex assembly
      pfam16687
      Location:2 → 489
      ELYS-bb; beta-propeller of ELYS nucleoporin
    Nucleotide Protein Strain
    Heading Accession and Version

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