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    adprm ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent [ Danio rerio (zebrafish) ]

    Gene ID: 393393, updated on 9-Dec-2024

    Summary

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    Official Symbol
    adprmprovided by ZNC
    Official Full Name
    ADP-ribose/CDP-alcohol diphosphatase, manganese-dependentprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1406
    See related
    Ensembl:ENSDARG00000026090 AllianceGenome:ZFIN:ZDB-GENE-040426-1406
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:64213
    Summary
    Enables 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity; manganese ion binding activity; and pyrophosphatase activity. Orthologous to human ADPRM (ADP-ribose/CDP-alcohol diphosphatase, manganese dependent). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See adprm in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (288108..290784, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (90486..96184, complement)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene myocardin Neighboring gene myosin-16 Neighboring gene mitogen-activated protein kinase kinase 4b Neighboring gene growth arrest-specific protein 7-like Neighboring gene uncharacterized LOC108191687

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Characterization of Danio rerio Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase, the structural prototype of the ADPRibase-Mn-like protein family. Rodrigues JR, et al. PLoS One, 2012. PMID 22848751, Free PMC Article
    2. Molecular bases of catalysis and ADP-ribose preference of human Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase and conversion by mutagenesis to a preferential cyclic ADP-ribose phosphohydrolase. Cabezas A, et al. PLoS One, 2015. PMID 25692488, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. structure-function correlation of Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase
      Title: Characterization of Danio rerio Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase, the structural prototype of the ADPRibase-Mn-like protein family.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC64213

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ADP-ribose diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ADP-ribose diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ADP-ribose diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables CDP-glycerol diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables CDP-glycerol diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables CDP-glycerol diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables manganese ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    manganese-dependent ADP-ribose/CDP-alcohol diphosphatase
    Names
    ADPRibase-Mn
    CDP-choline phosphohydrolase
    NP_956715.1
    XP_009304625.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200421.1 → NP_956715.1  manganese-dependent ADP-ribose/CDP-alcohol diphosphatase

      See identical proteins and their annotated locations for NP_956715.1

      Status: PROVISIONAL

      Source sequence(s)
      BC054642
      UniProtKB/Swiss-Prot
      Q7T291
      UniProtKB/TrEMBL
      A0A8M9QME1
      Related
      ENSDARP00000096471.3, ENSDART00000105694.6
      Conserved Domains (1) summary
      cd07396
      Location:6 → 309
      MPP_Nbla03831; Homo sapiens Nbla03831 and related proteins, metallophosphatase domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      288108..290784 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009306350.4 → XP_009304625.1  manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1

      UniProtKB/TrEMBL
      A0A8M3BDX7, A0A8M9QME1, F1R6I0
      Conserved Domains (1) summary
      cd07396
      Location:6 → 309
      MPP_Nbla03831; Homo sapiens Nbla03831 and related proteins, metallophosphatase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7T291.1 GenPept UniProtKB/Swiss-Prot:Q7T291

    Gene LinkOut

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