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    ptprfb protein tyrosine phosphatase receptor type Fb [ Danio rerio (zebrafish) ]

    Gene ID: 799867, updated on 4-Jan-2025

    Summary

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    Official Symbol
    ptprfbprovided by ZNC
    Official Full Name
    protein tyrosine phosphatase receptor type Fbprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060503-530
    See related
    Ensembl:ENSDARG00000005754 AllianceGenome:ZFIN:ZDB-GENE-060503-530
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    lar; ptprf; fj23e12; wu:fj23e12; si:dkey-21k10.1
    Summary
    Predicted to enable protein tyrosine phosphatase activity. Acts upstream of or within sensory neuron axon guidance. Predicted to be located in plasma membrane. Is expressed in liver and nervous system. Human ortholog(s) of this gene implicated in hyperinsulinism. Orthologous to human PTPRF (protein tyrosine phosphatase receptor type F). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See ptprfb in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (17578415..17947232, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (17907246..18276081, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene serine/threonine-protein kinase pim-1-like Neighboring gene serine/threonine-protein kinase pim-1-like Neighboring gene uncharacterized LOC101886917 Neighboring gene uncharacterized LOC137487773 Neighboring gene uncharacterized LOC137487776

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. LAR receptor tyrosine phosphatases and HSPGs guide peripheral sensory axons to the skin. Wang F, et al. Curr Biol, 2012 Mar 6. PMID 22326027, Free PMC Article
    2. Evolution of Nova-dependent splicing regulation in the brain. Jelen N, et al. PLoS Genet, 2007 Oct. PMID 17937501, Free PMC Article
    3. Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes. Burguera D, et al. Nat Commun, 2017 Nov 27. PMID 29180615, Free PMC Article
    4. Identification and expression of the family of classical protein-tyrosine phosphatases in zebrafish. van Eekelen M, et al. PLoS One, 2010 Sep 3. PMID 20838449, Free PMC Article
    5. Zebrafish as a model to study PTPs during development. Paardekooper Overman J, et al. Methods, 2014 Jan 15. PMID 23974070

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC154028

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sensory neuron axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within sensory neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic membrane adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    receptor-type tyrosine-protein phosphatase F
    Names
    protein tyrosine phosphatase, receptor type, f, b
    NP_001077045.1
    XP_009296742.1
    XP_021337115.1
    XP_021337116.1
    XP_021337118.1
    XP_068069044.1
    XP_068069045.1
    XP_068069052.1
    XP_068069059.1
    XP_068069060.1
    XP_068069066.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083576.1 → NP_001077045.1  receptor-type tyrosine-protein phosphatase F precursor

      See identical proteins and their annotated locations for NP_001077045.1

      Status: PROVISIONAL

      Source sequence(s)
      BC134804
      UniProtKB/Swiss-Prot
      A4IFW2
      UniProtKB/TrEMBL
      A0A2R8QDC8, A0A8M3AX70
      Related
      ENSDARP00000077749.5, ENSDART00000083314.7
      Conserved Domains (9) summary
      cd00096
      Location:52 → 123
      Ig; Immunoglobulin domain
      cd05738
      Location:154 → 227
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:247 → 315
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00060
      Location:1012 → 1085
      FN3; Fibronectin type 3 domain
      smart00194
      Location:1354 → 1608
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:143 → 226
      IG_like; Immunoglobulin like
      cd00047
      Location:1379 → 1608
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:320 → 409
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:35 → 126
      I-set; Immunoglobulin I-set domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      17578415..17947232 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021481440.2 → XP_021337115.1  receptor-type tyrosine-protein phosphatase F isoform X7

      UniProtKB/TrEMBL
      A0A8M3B074, A0A8M9QPW8
      Related
      ENSDARP00000155871.1, ENSDART00000191872.1
      Conserved Domains (5) summary
      cd05739
      Location:247 → 315
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd00047
      Location:1268 → 1497
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:320 → 409
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:35 → 126
      I-set; Immunoglobulin I-set domain
      cd05738
      Location:155 → 227
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

    2. XM_021481443.2 → XP_021337118.1  receptor-type tyrosine-protein phosphatase F isoform X6

      UniProtKB/TrEMBL
      A0A8M9QC27, A0A8M9QC31
      Conserved Domains (7) summary
      cd05739
      Location:247 → 315
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00060
      Location:910 → 983
      FN3; Fibronectin type 3 domain
      cd00047
      Location:1277 → 1506
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:320 → 409
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:35 → 126
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:609 → 707
      fn3; Fibronectin type III domain
      cd05738
      Location:155 → 227
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

    3. XM_009298467.4 → XP_009296742.1  receptor-type tyrosine-protein phosphatase F isoform X4

      UniProtKB/TrEMBL
      A0A8M3APM3, A0A8M3B7N0
      Conserved Domains (9) summary
      cd00096
      Location:52 → 123
      Ig; Immunoglobulin domain
      cd05738
      Location:154 → 227
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:247 → 315
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00060
      Location:1003 → 1076
      FN3; Fibronectin type 3 domain
      smart00194
      Location:1345 → 1599
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:143 → 226
      IG_like; Immunoglobulin like
      cd00047
      Location:1370 → 1599
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:320 → 409
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:35 → 126
      I-set; Immunoglobulin I-set domain

    4. XM_068212958.1 → XP_068069059.1  receptor-type tyrosine-protein phosphatase F isoform X2

      UniProtKB/Swiss-Prot
      A4IFW2
      UniProtKB/TrEMBL
      A0A2R8QDC8, A0A8M3AX70
      Related
      ENSDARP00000151637.1, ENSDART00000184039.1

    5. XM_021481441.2 → XP_021337116.1  receptor-type tyrosine-protein phosphatase F isoform X5

      UniProtKB/TrEMBL
      A0A8M9Q0G3, A0A8M9QLG3
      Conserved Domains (7) summary
      cd05739
      Location:253 → 321
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00060
      Location:916 → 989
      FN3; Fibronectin type 3 domain
      cd00047
      Location:1283 → 1512
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:326 → 415
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:35 → 126
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:615 → 713
      fn3; Fibronectin type III domain
      cd05738
      Location:155 → 233
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR

    6. XM_068212959.1 → XP_068069060.1  receptor-type tyrosine-protein phosphatase F isoform X3

      UniProtKB/TrEMBL
      A0A8M3APM3
      Related
      ENSDARP00000156606.1, ENSDART00000179791.1

    7. XM_068212943.1 → XP_068069044.1  receptor-type tyrosine-protein phosphatase F isoform X1

      UniProtKB/TrEMBL
      A0A8M3AQ56
      Related
      ENSDARP00000156870.1, ENSDART00000190089.1

    8. XM_068212944.1 → XP_068069045.1  receptor-type tyrosine-protein phosphatase F isoform X1

      UniProtKB/TrEMBL
      A0A8M3AQ56
      Related
      ENSDARP00000132216.2, ENSDART00000166518.3

    9. XM_068212951.1 → XP_068069052.1  receptor-type tyrosine-protein phosphatase F isoform X1

      UniProtKB/TrEMBL
      A0A8M3AQ56

    10. XM_068212965.1 → XP_068069066.1  receptor-type tyrosine-protein phosphatase F isoform X8

      UniProtKB/TrEMBL
      A0A8M3B7M8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4IFW2.1 GenPept UniProtKB/Swiss-Prot:A4IFW2

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