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    ifi27.2 interferon alpha inducible protein 27.2 [ Danio rerio (zebrafish) ]

    Gene ID: 641326, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ifi27.2provided by ZNC
    Official Full Name
    interferon alpha inducible protein 27.2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060901-4
    See related
    Ensembl:ENSDARG00000039243 AllianceGenome:ZFIN:ZDB-GENE-060901-4
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ifi27; isg12-2; isg12.1; isg12.2; zgc:123067; zgc:152791; zgc:158560
    Summary
    Predicted to enable molecular adaptor activity. Predicted to be involved in intrinsic apoptotic signaling pathway and release of cytochrome c from mitochondria. Predicted to be located in membrane. Predicted to be active in mitochondrial membrane. Orthologous to several human genes including IFI27 (interferon alpha inducible protein 27). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ifi27.2 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (37617515..37620290, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (37491625..37494400, complement)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene interferon alpha inducible protein 27.1 Neighboring gene interferon alpha inducible protein 27.3 Neighboring gene interferon alpha inducible protein 27.4 Neighboring gene uncharacterized LOC101885881

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Treatment with a DNA methyltransferase inhibitor feminizes zebrafish and induces long-term expression changes in the gonads. Ribas L, et al. Epigenetics Chromatin, 2017 Dec 8. PMID 29216900, Free PMC Article
    2. Pericentromeric hypomethylation elicits an interferon response in an animal model of ICF syndrome. Rajshekar S, et al. Elife, 2018 Nov 28. PMID 30484769, Free PMC Article
    3. Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour. Filiano AJ, et al. Nature, 2016 Jul 21. PMID 27409813, Free PMC Article
    4. Evolutionary conserved pro-inflammatory and antigen presentation functions of zebrafish IFNγ revealed by transcriptomic and functional analysis. López-Muñoz A, et al. Mol Immunol, 2011 May. PMID 21354627
    5. Understanding complex dynamics of behavioral, neurochemical and transcriptomic changes induced by prolonged chronic unpredictable stress in zebrafish. Demin KA, et al. Sci Rep, 2020 Nov 17. PMID 33203921, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Clone Names

    • MGC123067, MGC152791, MGC158560

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in intrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in release of cytochrome c from mitochondria IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    interferon alpha inducible protein 27.2
    Names
    interferon stimulated gene 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007133.3 → NP_001007134.2  interferon alpha inducible protein 27.2

      See identical proteins and their annotated locations for NP_001007134.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      DY573454, EB984692
      UniProtKB/TrEMBL
      A0A8M1P1C3, F6NVZ1
      Related
      ENSDARP00000011827.7, ENSDART00000018064.9
      Conserved Domains (1) summary
      pfam06140
      Location:24 → 89
      Ifi-6-16; Interferon-induced 6-16 family

    2. NM_001291934.1 → NP_001278863.1  interferon alpha inducible protein 27.2

      See identical proteins and their annotated locations for NP_001278863.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      DY573454, EB984692
      UniProtKB/TrEMBL
      A0A8M1P1C3, F6NVZ1
      Related
      ENSDARP00000147083.1, ENSDART00000193270.1
      Conserved Domains (1) summary
      pfam06140
      Location:24 → 89
      Ifi-6-16; Interferon-induced 6-16 family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      37617515..37620290 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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