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    fgd5a FYVE, RhoGEF and PH domain containing 5a [ Danio rerio (zebrafish) ]

    Gene ID: 100151562, updated on 2-Nov-2024

    Summary

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    Official Symbol
    fgd5aprovided by ZNC
    Official Full Name
    FYVE, RhoGEF and PH domain containing 5aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-090428-3
    See related
    Ensembl:ENSDARG00000088801 AllianceGenome:ZFIN:ZDB-GENE-090428-3
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Is expressed in blood island; cranial vasculature; and trunk vasculature. Orthologous to human FGD5 (FYVE, RhoGEF and PH domain containing 5). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See fgd5a in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (18396148..18468568, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (18236342..18306210, complement)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene Scm like with four mbt domains 1 Neighboring gene protein kinase C, delta b Neighboring gene death inducer-obliterator 1 Neighboring gene zinc finger, MYND-type containing 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Cdc42 mediates Bmp-induced sprouting angiogenesis through Fmnl3-driven assembly of endothelial filopodia in zebrafish. Wakayama Y, et al. Dev Cell, 2015 Jan 12. PMID 25584797
    2. Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish. Xiao A, et al. Nucleic Acids Res, 2013 Aug. PMID 23748566, Free PMC Article
    3. G protein-coupled receptor 183 facilitates endothelial-to-hematopoietic transition via Notch1 inhibition. Zhang P, et al. Cell Res, 2015 Oct. PMID 26358189, Free PMC Article
    4. Reverse genetic screening reveals poor correlation between morpholino-induced and mutant phenotypes in zebrafish. Kok FO, et al. Dev Cell, 2015 Jan 12. PMID 25533206, Free PMC Article
    5. Discovery and characterization of novel vascular and hematopoietic genes downstream of etsrp in zebrafish. Gomez GA, et al. PLoS One, 2009. PMID 19308258, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    FYVE, RhoGEF and PH domain-containing protein 5
    Names
    fgd5
    zmp:0000000940

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      18396148..18468568 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021479796.2 → XP_021335471.1  FYVE, RhoGEF and PH domain-containing protein 5 isoform X2

      UniProtKB/TrEMBL
      A0A8M2B1Z4
      Conserved Domains (5) summary
      smart00325
      Location:919 → 1103
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd15792
      Location:1121 → 1243
      PH1_FGD5; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia protein 5, N-terminal Pleckstrin Homology (PH) domain
      cd15742
      Location:1255 → 1321
      FYVE_FGD5; FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 5 (FGD5) and similar proteins
      cl17171
      Location:1377 → 1458
      PH-like; Pleckstrin homology-like domain
      cl28246
      Location:25 → 149
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    2. XM_021479795.2 → XP_021335470.1  FYVE, RhoGEF and PH domain-containing protein 5 isoform X1

      UniProtKB/TrEMBL
      A0A8M9QLY3, X1WDS7
      Related
      ENSDARP00000128376.2, ENSDART00000155474.3
      Conserved Domains (5) summary
      smart00325
      Location:919 → 1103
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd13237
      Location:1377 → 1467
      PH2_FGD5_FGD6; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 5 and 6 pleckstrin homology (PH) domain, C-terminus
      cd15792
      Location:1121 → 1243
      PH1_FGD5; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia protein 5, N-terminal Pleckstrin Homology (PH) domain
      cd15742
      Location:1255 → 1321
      FYVE_FGD5; FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 5 (FGD5) and similar proteins
      cl28246
      Location:25 → 149
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394814.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      313439..383148 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001919859.7 → XP_001919894.2  FYVE, RhoGEF and PH domain-containing protein 5 isoform X1

      UniProtKB/TrEMBL
      A0A8M9QLY3, X1WDS7
      Conserved Domains (5) summary
      smart00325
      Location:919 → 1103
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd13237
      Location:1377 → 1467
      PH2_FGD5_FGD6; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 5 and 6 pleckstrin homology (PH) domain, C-terminus
      cd15792
      Location:1121 → 1243
      PH1_FGD5; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia protein 5, N-terminal Pleckstrin Homology (PH) domain
      cd15742
      Location:1255 → 1321
      FYVE_FGD5; FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 5 (FGD5) and similar proteins
      cl28246
      Location:25 → 149
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    2. XM_005155840.5 → XP_005155897.1  FYVE, RhoGEF and PH domain-containing protein 5 isoform X2

      UniProtKB/TrEMBL
      A0A8M2B1Z4
      Conserved Domains (5) summary
      smart00325
      Location:919 → 1103
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd15792
      Location:1121 → 1243
      PH1_FGD5; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia protein 5, N-terminal Pleckstrin Homology (PH) domain
      cd15742
      Location:1255 → 1321
      FYVE_FGD5; FYVE-like domain found in FYVE, RhoGEF and PH domain-containing protein 5 (FGD5) and similar proteins
      cl17171
      Location:1377 → 1458
      PH-like; Pleckstrin homology-like domain
      cl28246
      Location:25 → 149
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein Strain
    Heading Accession and Version

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