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    ldhd lactate dehydrogenase D [ Danio rerio (zebrafish) ]

    Gene ID: 334208, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ldhdprovided by ZNC
    Official Full Name
    lactate dehydrogenase Dprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6140
    See related
    Ensembl:ENSDARG00000038845 AllianceGenome:ZFIN:ZDB-GENE-030131-6140
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    DLD; zgc:55447; wu:fi36b04
    Summary
    Predicted to enable D-lactate dehydrogenase (cytochrome) activity; D-lactate dehydrogenase activity; and flavin adenine dinucleotide binding activity. Involved in lactate catabolic process. Predicted to be active in mitochondrion. Orthologous to human LDHD (lactate dehydrogenase D). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ldhd in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (13473938..13490697, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (13377538..13394297, complement)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene GINS complex subunit 3 Neighboring gene zinc and ring finger 1 Neighboring gene SNF related kinase b Neighboring gene anoctamin 10b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification of human D lactate dehydrogenase deficiency. Monroe GR, et al. Nat Commun, 2019 Apr 1. PMID 30931947, Free PMC Article
    2. The TATA-binding protein regulates maternal mRNA degradation and differential zygotic transcription in zebrafish. Ferg M, et al. EMBO J, 2007 Sep 5. PMID 17703193, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables D-lactate dehydrogenase (cytochrome) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables D-lactate dehydrogenase (cytochrome) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables D-lactate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lactate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lactate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable D-lactate dehydrogenase, mitochondrial
    NP_956167.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199873.1 → NP_956167.1  probable D-lactate dehydrogenase, mitochondrial

      See identical proteins and their annotated locations for NP_956167.1

      Status: PROVISIONAL

      Source sequence(s)
      BC044171
      UniProtKB/Swiss-Prot
      F1QXM5, Q803V9
      Related
      ENSDARP00000056720.4, ENSDART00000056721.5
      Conserved Domains (3) summary
      COG0277
      Location:38 → 488
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
      pfam01565
      Location:70 → 206
      FAD_binding_4; FAD binding domain
      pfam02913
      Location:247 → 487
      FAD-oxidase_C; FAD linked oxidases, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      13473938..13490697 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F1QXM5.1 GenPept UniProtKB/Swiss-Prot:F1QXM5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.