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    csrnp1a cysteine-serine-rich nuclear protein 1a [ Danio rerio (zebrafish) ]

    Gene ID: 560270, updated on 2-Nov-2024

    Summary

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    Official Symbol
    csrnp1aprovided by ZNC
    Official Full Name
    cysteine-serine-rich nuclear protein 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070912-475
    See related
    Ensembl:ENSDARG00000031426 AllianceGenome:ZFIN:ZDB-GENE-070912-475
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-24c2.8
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Acts upstream of or within primitive hemopoiesis. Predicted to be active in nucleus. Is expressed in intermediate cell mass of mesoderm. Orthologous to human CSRNP1 (cysteine and serine rich nuclear protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See csrnp1a in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (23790889..23805139)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (24135143..24149223)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 member 13a Neighboring gene xin actin binding repeat containing 1 Neighboring gene uncharacterized LOC110438028 Neighboring gene golgi reassembly stacking protein 1a Neighboring gene uncharacterized LOC137487820 Neighboring gene VOPP1 WW domain binding protein a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification of apoptosis-related genes and transcription variations in response to microcystin-LR in zebrafish liver. Wei L, et al. Toxicol Ind Health, 2014 Oct. PMID 23064767
    2. Cystein-serine-rich nuclear protein 1, Axud1/Csrnp1, is essential for cephalic neural progenitor proliferation and survival in zebrafish. Feijóo CG, et al. Dev Dyn, 2009 Aug. PMID 19544579
    3. csrnp1a is necessary for the development of primitive hematopoiesis progenitors in zebrafish. Espina J, et al. PLoS One, 2013. PMID 23326522, Free PMC Article
    4. Global analysis of the haematopoietic and endothelial transcriptome during zebrafish development. Cannon JE, et al. Mech Dev, 2013 Feb. PMID 23072875, Free PMC Article
    5. Evolution of gene function and regulatory control after whole-genome duplication: comparative analyses in vertebrates. Kassahn KS, et al. Genome Res, 2009 Aug. PMID 19439512, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Csrnp1a knockdown generates a mild reduction in head size and a depletion of blood cells in circulation
      Title: csrnp1a is necessary for the development of primitive hematopoiesis progenitors in zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within primitive hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cysteine/serine-rich nuclear protein 1
    Names
    axud1
    csrnp1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      23790889..23805139
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_683666.9 → XP_688758.3  cysteine/serine-rich nuclear protein 1

      UniProtKB/TrEMBL
      A0A8N7TEV8, B0S776
      Related
      ENSDARP00000041876.5, ENSDART00000041877.7
      Conserved Domains (1) summary
      pfam16019
      Location:91 → 306
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
    Nucleotide Protein
    Heading Accession and Version

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