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    mknk1 MAPK interacting serine/threonine kinase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 555974, updated on 14-Nov-2024

    Summary

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    Official Symbol
    mknk1provided by ZNC
    Official Full Name
    MAPK interacting serine/threonine kinase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080220-11
    See related
    Ensembl:ENSDARG00000018411 AllianceGenome:ZFIN:ZDB-GENE-080220-11
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:171912
    Summary
    Predicted to enable calcium-dependent protein serine/threonine kinase activity; calcium/calmodulin-dependent protein kinase activity; and calmodulin binding activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation and regulation of translation. Predicted to be active in cytoplasm and nucleus. Orthologous to human MKNK1 (MAPK interacting serine/threonine kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See mknk1 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (13176568..13189751)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (13118898..13132092)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene ELOVL fatty acid elongase 1b Neighboring gene MOB kinase activator 3C Neighboring gene ATP synthase F1 subunit beta Neighboring gene ATP-binding cassette, sub-family B (MDR/TAP), member 11b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RESA identifies mRNA-regulatory sequences at high resolution. Yartseva V, et al. Nat Methods, 2017 Feb. PMID 28024160, Free PMC Article
    2. Comparative transcriptomic profiling of hydrogen peroxide signaling networks in zebrafish and human keratinocytes: Implications toward conservation, migration and wound healing. Lisse TS, et al. Sci Rep, 2016 Feb 5. PMID 26846883, Free PMC Article
    3. Dynamic RNA-protein interactions underlie the zebrafish maternal-to-zygotic transition. Despic V, et al. Genome Res, 2017 Jul. PMID 28381614, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC171912

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    MAP kinase-interacting serine/threonine-protein kinase 1
    Names
    MAP kinase interacting serine/threonine kinase 1
    NP_001108211.2
    XP_005156011.1
    XP_005156012.1
    XP_005156013.1
    XP_068080274.1
    XP_068080275.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114739.2 → NP_001108211.2  MAP kinase-interacting serine/threonine-protein kinase 1

      Status: VALIDATED

      Source sequence(s)
      CR847923
      UniProtKB/TrEMBL
      A0A8M1NGA1, F1QJV2
      Related
      ENSDARP00000111297.1, ENSDART00000125371.3
      Conserved Domains (2) summary
      smart00220
      Location:100 → 380
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14174
      Location:93 → 381
      STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      13176568..13189751
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005155954.5 → XP_005156011.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B223
      Conserved Domains (2) summary
      smart00220
      Location:102 → 411
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:95 → 412
      PKc_like; Protein Kinases, catalytic domain

    2. XM_005155956.5 → XP_005156013.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X3

      UniProtKB/TrEMBL
      A0A8M2B2B7
      Conserved Domains (2) summary
      smart00220
      Location:102 → 382
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14174
      Location:95 → 383
      STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

    3. XM_068224173.1 → XP_068080274.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X3

    4. XM_005155955.5 → XP_005156012.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M2B1Y9
      Conserved Domains (2) summary
      smart00220
      Location:100 → 409
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:93 → 410
      PKc_like; Protein Kinases, catalytic domain

    5. XM_068224174.1 → XP_068080275.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X4

    Nucleotide Protein
    Heading Accession and Version

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