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    elovl8b ELOVL fatty acid elongase 8b [ Danio rerio (zebrafish) ]

    Gene ID: 554145, updated on 2-Nov-2024

    Summary

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    Official Symbol
    elovl8bprovided by ZNC
    Official Full Name
    ELOVL fatty acid elongase 8bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050522-453
    See related
    Ensembl:ENSDARG00000057365 AllianceGenome:ZFIN:ZDB-GENE-050522-453
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7139490; zgc:112263
    Summary
    Predicted to enable fatty acid elongase activity. Predicted to be involved in fatty acid biosynthetic process and sphingolipid biosynthetic process. Predicted to act upstream of or within fatty acid biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See elovl8b in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (18200334..18203329, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (18164622..18167617, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein GLIS1 Neighboring gene ribosomal protein S8b Neighboring gene mutY DNA glycosylase Neighboring gene guanylate kinase 1b Neighboring gene ring finger protein 220b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution and Functional Characteristics of the Novel elovl8 That Play Pivotal Roles in Fatty Acid Biosynthesis. Sun S, et al. Genes (Basel), 2021 Aug 23. PMID 34440461, Free PMC Article
    2. Lipid-related metabolism during zebrafish embryogenesis under unbalanced copper homeostasis. Li C, et al. Fish Physiol Biochem, 2022 Dec. PMID 36161547
    3. The impact of deleting the mitfa gene in zebrafish on the intestinal microbiota community. Chen Q, et al. Gene, 2022 Dec 20. PMID 36075325
    4. Enoyl-CoA hydratase/3-hydroxyacyl CoA dehydrogenase is essential for the production of DHA in zebrafish. Yang G, et al. J Lipid Res, 2023 Mar. PMID 36592657, Free PMC Article
    5. Vitellogenin 1 is essential for fish reproduction by transporting DHA-containing phosphatidylcholine from liver to ovary. Sun SX, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2023 Apr. PMID 36708962

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Evolution and Functional Characteristics of the Novel elovl8 That Play Pivotal Roles in Fatty Acid Biosynthesis.
      Title: Evolution and Functional Characteristics of the Novel elovl8 That Play Pivotal Roles in Fatty Acid Biosynthesis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables fatty acid elongase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acid elongase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid elongation, monounsaturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid elongation, polyunsaturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid elongation, saturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sphingolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in very long-chain fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ELOVL fatty acid elongase 8b
    Names
    elongation of very long chain fatty acids protein 4-like
    NP_001019609.2
    NP_001191453.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024438.2 → NP_001019609.2  ELOVL fatty acid elongase 8b

      See identical proteins and their annotated locations for NP_001019609.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      EH498162, EH519540, EH524440
      UniProtKB/TrEMBL
      A0A8M1P1U9, B8JJK4, F1R324
      Related
      ENSDARP00000123230.1, ENSDART00000142114.3
      Conserved Domains (1) summary
      pfam01151
      Location:31 → 264
      ELO; GNS1/SUR4 family

    2. NM_001204524.1 → NP_001191453.1  ELOVL fatty acid elongase 8b

      See identical proteins and their annotated locations for NP_001191453.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      CT025742, EH498162, EH519540, EH524440, EH584885
      UniProtKB/TrEMBL
      A0A8M1P1U9, B8JJK4, F1R324
      Related
      ENSDARP00000107017.2, ENSDART00000125418.3
      Conserved Domains (1) summary
      pfam01151
      Location:31 → 264
      ELO; GNS1/SUR4 family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      18200334..18203329 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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