gmppaa GDP-mannose pyrophosphorylase Aa [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gmppaaprovided by ZNC
Official Full Name: GDP-mannose pyrophosphorylase Aaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040704-37
See related: Ensembl:ENSDARG00000024112 AllianceGenome:ZFIN:ZDB-GENE-040704-37
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:91853
Summary: Predicted to enable GTP binding activity and mannose-1-phosphate guanylyltransferase (GTP) activity. Predicted to be involved in GDP-mannose biosynthetic process. Predicted to act upstream of or within biosynthetic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in alacrima, achalasia, and impaired intellectual development syndrome. Orthologous to human GMPPA (GDP-mannose pyrophosphorylase A). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 9

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (10770628..10779267)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (10799296..10807963)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables mannose-1-phosphate guanylyltransferase (GTP) activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in GDP-mannose biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: mannose-1-phosphate guanylyltransferase regulatory subunit alpha-A; mannose-1-phosphate guanyltransferase alpha-A

Names: GDP-mannose pyrophosphorylase A-A; GTP-mannose-1-phosphate guanylyltransferase subunit alpha-A

NP_001002196.1

EC 2.7.7.13

XP_005167533.1

EC 2.7.7.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002196.1 → NP_001002196.1 mannose-1-phosphate guanylyltransferase regulatory subunit alpha-A

See identical proteins and their annotated locations for NP_001002196.1

Status: PROVISIONAL

Source sequence(s)

BC074036

UniProtKB/Swiss-Prot

Q6GMK8

Related

ENSDARP00000143324.2, ENSDART00000178966.2

Conserved Domains (3) summary

cd06428
Location:4 → 263

M1P_guanylylT_A_like_N; N-terminal domain of M1P_guanylyl_A_ like proteins are likely to be a isoform of GDP-mannose pyrophosphorylase

COG1208
Location:1 → 351

GCD1; NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis proteins [Translation, ribosomal structure and biogenesis, Cell wall/membrane/envelope biogenesis]

cl00160
Location:291 → 357

LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007120.7 Reference GRCz11 Primary Assembly

Range

10770628..10779267

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005167476.5 → XP_005167533.1 mannose-1-phosphate guanyltransferase alpha-A isoform X1

UniProtKB/TrEMBL

A0A286Y8P7, A0A8M2BEX2

Related

ENSDARP00000017348.7, ENSDART00000003543.8

Conserved Domains (3) summary

cd06428
Location:4 → 268

M1P_guanylylT_A_like_N; N-terminal domain of M1P_guanylyl_A_ like proteins are likely to be a isoform of GDP-mannose pyrophosphorylase

COG1208
Location:1 → 356

GCD1; NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis proteins [Translation, ribosomal structure and biogenesis, Cell wall/membrane/envelope biogenesis]

cl00160
Location:296 → 362

LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...