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    tpk1 thiamin pyrophosphokinase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 450054, updated on 2-Nov-2024

    Summary

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    Official Symbol
    tpk1provided by ZNC
    Official Full Name
    thiamin pyrophosphokinase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041010-176
    See related
    Ensembl:ENSDARG00000038040 AllianceGenome:ZFIN:ZDB-GENE-041010-176
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:101685
    Summary
    Predicted to enable thiamine diphosphokinase activity. Predicted to be involved in thiamine diphosphate biosynthetic process. Predicted to act upstream of or within phosphorylation and thiamine metabolic process. Human ortholog(s) of this gene implicated in inherited metabolic disorder. Orthologous to human TPK1 (thiamin pyrophosphokinase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See tpk1 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (18286427..18444729)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (18142008..18300314)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene contactin associated protein 2a Neighboring gene uncharacterized LOC137489233 Neighboring gene uncharacterized LOC137489287 Neighboring gene si:dkey-73n8.3 Neighboring gene zgc:112332 Neighboring gene SEC61 translocon subunit gamma

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiamine binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiamine diphosphokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thiamine diphosphokinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thiamine diphosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within thiamine diphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thiamine diphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within thiamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    thiamine pyrophosphokinase 1
    NP_001006074.1
    XP_005162672.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006074.1 → NP_001006074.1  thiamine pyrophosphokinase 1

      See identical proteins and their annotated locations for NP_001006074.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083247
      UniProtKB/TrEMBL
      Q5XJQ1
      Related
      ENSDARP00000055442.5, ENSDART00000055443.7
      Conserved Domains (2) summary
      cd07995
      Location:19 → 243
      TPK; Thiamine pyrophosphokinase
      PLN02714
      Location:20 → 247
      PLN02714; thiamin pyrophosphokinase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      18286427..18444729
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005162615.5 → XP_005162672.1  thiamine pyrophosphokinase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B9G6, F1RBJ9
      Conserved Domains (2) summary
      cd07995
      Location:19 → 243
      TPK; Thiamine pyrophosphokinase
      PLN02714
      Location:20 → 247
      PLN02714; thiamin pyrophosphokinase

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395169.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      26024..127082
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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