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    ttbk2b tau tubulin kinase 2b [ Danio rerio (zebrafish) ]

    Gene ID: 569881, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ttbk2bprovided by ZNC
    Official Full Name
    tau tubulin kinase 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8246
    See related
    Ensembl:ENSDARG00000043026 AllianceGenome:ZFIN:ZDB-GENE-030131-8246
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fj62e10; sb:eu1102; wu:fj62e10; si:dkey-12h9.11; si:dkey-12h9.14
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in cilium assembly and signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in several cellular components, including ciliary basal body; ciliary transition zone; and nucleus. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 11. Orthologous to human TTBK2 (tau tubulin kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ttbk2b in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (25911538..25928355)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (26012448..26029265)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene mitotic deacetylase associated SANT domain protein a Neighboring gene solute carrier family 35 member F6 Neighboring gene uncharacterized LOC101885405 Neighboring gene churchill domain containing 1 Neighboring gene zinc finger protein 106b Neighboring gene calpain 3b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Whole Genome Sequencing-Based Mapping and Candidate Identification of Mutations from Fixed Zebrafish Tissue. Sanchez NE, et al. G3 (Bethesda), 2017 Oct 5. PMID 28855284, Free PMC Article
    2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in ciliary transition zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tau-tubulin kinase 2b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001326291.1 → NP_001313220.1  tau-tubulin kinase 2b

      Status: VALIDATED

      Source sequence(s)
      AL954831
      UniProtKB/TrEMBL
      A0A8M1P8V6, F1Q8Z7, F1RC23
      Related
      ENSDARP00000115574.2, ENSDART00000146004.3
      Conserved Domains (2) summary
      COG0515
      Location:21 → 361
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14017
      Location:20 → 281
      STKc_TTBK; Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      25911538..25928355
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395074.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      26919..43736
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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