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    • Showing Current items.

    msna moesin a [ Danio rerio (zebrafish) ]

    Gene ID: 286739, updated on 2-Nov-2024

    Summary

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    Official Symbol
    msnaprovided by ZNC
    Official Full Name
    moesin aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-021211-2
    See related
    Ensembl:ENSDARG00000058128 AllianceGenome:ZFIN:ZDB-GENE-021211-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    rdx; cb567; zgc:85640; wu:fb14b03
    Summary
    Predicted to enable actin binding activity and cell adhesion molecule binding activity. Acts upstream of or within blood vessel lumenization and endoderm development. Predicted to be located in anchoring junction; cytoskeleton; and membrane. Predicted to be active in several cellular components, including adherens junction; filopodium; and microvillus. Is expressed in several structures, including cardiovascular system; gut; hypochord; nervous system; and swim bladder bud. Human ortholog(s) of this gene implicated in immunodeficiency 50. Orthologous to human MSN (moesin). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See msna in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (22133375..22174040)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (21629575..21670237)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene zinc finger CCCH-type containing 12B Neighboring gene uncharacterized LOC110438643 Neighboring gene LAS1 like ribosome biogenesis factor Neighboring gene ferredoxin 1b Neighboring gene uncharacterized LOC137495581 Neighboring gene microRNA 223

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Moesin signalling induces F9 teratocarcinoma cells to differentiate into primitive extraembryonic endoderm. Krawetz R, et al. Cell Signal, 2008 Jan. PMID 17993262
    2. Radixin is a constituent of stereocilia in hair cells. Pataky F, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983055, Free PMC Article
    3. The hyaloid vasculature facilitates basement membrane breakdown during choroid fissure closure in the zebrafish eye. James A, et al. Dev Biol, 2016 Nov 15. PMID 27634568, Free PMC Article
    4. Tol2 gene trap integrations in the zebrafish amyloid precursor protein genes appa and aplp2 reveal accumulation of secreted APP at the embryonic veins. Liao HK, et al. Dev Dyn, 2012 Feb. PMID 22275008, Free PMC Article
    5. Control of directed cell migration in vivo by membrane-to-cortex attachment. Diz-Muñoz A, et al. PLoS Biol, 2010 Nov 30. PMID 21151339, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. suggest that Ve-cadherin and Moesin1 function to establish and maintain apical/basal polarity during multicellular lumen formation in the intersegmental vessels
      Title: Moesin1 and Ve-cadherin are required in endothelial cells during in vivo tubulogenesis.
    2. results suggest a new role for moesin, acting in a signalling pathway facilitating the differentiation of extraembryonic endoderm
      Title: Moesin signalling induces F9 teratocarcinoma cells to differentiate into primitive extraembryonic endoderm.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC85640

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cell adhesion molecule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blood vessel lumenization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in developmental process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within endoderm development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of early endosome to late endosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of protein localization to early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of organelle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in apical part of cell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in filopodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microvillus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    moesin a
    Names
    moesin1
    msn1
    radixin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004296.1 → NP_001004296.1  moesin a

      See identical proteins and their annotated locations for NP_001004296.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081551
      UniProtKB/Swiss-Prot
      A0A8M1N247, A2CF04, Q66I42
      Related
      ENSDARP00000017246.8, ENSDART00000016214.9
      Conserved Domains (5) summary
      smart00295
      Location:7 → 206
      B41; Band 4.1 homologues
      cd13194
      Location:200 → 296
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      pfam00373
      Location:91 → 206
      FERM_M; FERM central domain
      pfam00769
      Location:347 → 579
      ERM; Ezrin/radixin/moesin family
      pfam09379
      Location:9 → 71
      FERM_N; FERM N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      22133375..22174040
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009301281.4 → XP_009299556.1  moesin a isoform X1

      UniProtKB/TrEMBL
      A0A8M3B2A2
      Conserved Domains (5) summary
      smart00295
      Location:1 → 195
      B41; Band 4.1 homologues
      cd13194
      Location:189 → 285
      FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
      pfam00373
      Location:80 → 195
      FERM_M; FERM central domain
      pfam00769
      Location:336 → 568
      ERM; Ezrin/radixin/moesin family
      pfam09379
      Location:2 → 60
      FERM_N; FERM N-terminal domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394572.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      125676..168348
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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