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    gp1bb glycoprotein Ib platelet subunit beta [ Danio rerio (zebrafish) ]

    Gene ID: 798998, updated on 2-Nov-2024

    Summary

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    Official Symbol
    gp1bbprovided by ZNC
    Official Full Name
    glycoprotein Ib platelet subunit betaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-081104-406
    See related
    Ensembl:ENSDARG00000074441 AllianceGenome:ZFIN:ZDB-GENE-081104-406
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-285c2.8
    Summary
    Predicted to act upstream of or within blood coagulation. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in Bernard-Soulier syndrome. Orthologous to human GP1BB (glycoprotein Ib platelet subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See gp1bb in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (4576132..4586719, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (4519426..4530033, complement)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene si:ch211-166a6.5 Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 37 Neighboring gene septin 5a Neighboring gene zgc:63587

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish von Willebrand factor. Carrillo M, et al. Blood Cells Mol Dis, 2010 Dec 15. PMID 21035359, Free PMC Article
    2. A transgenic zebrafish model for the in vivo study of the blood and choroid plexus brain barriers using claudin 5. van Leeuwen LM, et al. Biol Open, 2018 Feb 2. PMID 29437557, Free PMC Article
    3. Establishment of a congenital amegakaryocytic thrombocytopenia model and a thrombocyte-specific reporter line in zebrafish. Lin Q, et al. Leukemia, 2017 May. PMID 27811851
    4. Sex differences in DNA methylation and expression in zebrafish brain: a test of an extended 'male sex drive' hypothesis. Chatterjee A, et al. Gene, 2016 Sep 30. PMID 27259666
    5. Single-Cell RNA-Sequencing Reveals a Continuous Spectrum of Differentiation in Hematopoietic Cells. Macaulay IC, et al. Cell Rep, 2016 Feb 2. PMID 26804912, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within hemostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    platelet glycoprotein Ib beta chain
    Names
    glycoprotein Ib (platelet), beta polypeptide

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001144812.1 → NP_001138284.1  platelet glycoprotein Ib beta chain precursor

      Status: PROVISIONAL

      Source sequence(s)
      CU469504
      UniProtKB/TrEMBL
      A0A8M1NSY9, B8JLP1
      Related
      ENSDARP00000118508.1, ENSDART00000143511.3
      Conserved Domains (4) summary
      smart00013
      Location:21 → 54
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:84 → 129
      LRRCT; Leucine rich repeat C-terminal domain
      sd00031
      Location:53 → 75
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:31 → 51
      LRR_RI; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      4576132..4586719 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068223039.1 → XP_068079140.1  platelet glycoprotein Ib beta chain isoform X1

    2. XM_068223040.1 → XP_068079141.1  platelet glycoprotein Ib beta chain isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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