hif1al2 hypoxia inducible factor 1 subunit alpha, like 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hif1al2provided by ZNC
Official Full Name: hypoxia inducible factor 1 subunit alpha, like 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-050211-2
See related: Ensembl:ENSDARG00000044550 AllianceGenome:ZFIN:ZDB-GENE-050211-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: hif1al; zgc:112119
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in cellular response to hypoxia and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including digestive system; gill; head; heart; and pleuroperitoneal region. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 21

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (27327424..27339276, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (27290729..27302656, complement)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prominent changes were seen for Hif-2alpha expression, which significantly increased after the first day of exercise and then decreased down to values significantly below control values.
Title: HIF signaling and overall gene expression changes during hypoxia and prolonged exercise differ considerably.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to hypoxia	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: hypoxia inducible factor 1 subunit alpha, like 2

Names: HIF3B; Hif2a; hypoxia-inducible factor 1, alpha subunit, like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012371.2 → NP_001012371.2 hypoxia inducible factor 1 subunit alpha, like 2

See identical proteins and their annotated locations for NP_001012371.2

Status: VALIDATED

Source sequence(s)

BX530031, CK030317, DT057411

UniProtKB/TrEMBL

A0A8M2B8B7, F1QQQ1

Related

ENSDARP00000108595.2, ENSDART00000130632.4

Conserved Domains (6) summary

cd00083
Location:36 → 86

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

cd00130
Location:243 → 340

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00989
Location:111 → 184

PAS; PAS fold

pfam08447
Location:254 → 341

PAS_3; PAS fold

pfam08778
Location:620 → 656

HIF-1a_CTAD; HIF-1 alpha C terminal transactivation domain

pfam11413
Location:429 → 461

HIF-1; Hypoxia-inducible factor-1

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007132.7 Reference GRCz11 Primary Assembly

Range

27327424..27339276 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021468817.2 → XP_021324492.1 hypoxia inducible factor 1 subunit alpha, like 2 isoform X1

UniProtKB/TrEMBL

A0A8M9P3A0

Conserved Domains (3) summary

cd00130
Location:176 → 273

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam08778
Location:553 → 589

HIF-1a_CTAD; HIF-1 alpha C terminal transactivation domain

pfam11413
Location:363 → 394

HIF-1; Hypoxia-inducible factor-1